Article
Chemistry, Medicinal
Run-Ze Liu, Wen-Jun Li, Juan-Juan Zhang, Zheng-Yi Liu, Ya Li, Chao Liu, Song Qin
Summary: Phycocyanin has antioxidant and anti-inflammatory effects, which may inhibit oxidative stress and inflammation by inducing the expression of heme oxygenase 1, thereby relieving pulmonary fibrosis symptoms.
Article
Environmental Sciences
Ibtesam S. Alanazi, Mohamed Emam, Mabrouk Elsabagh, Saad Alkahtani, Mohamed M. Abdel-Daim
Summary: This study found that 18 beta GA can increase antioxidant defenses in the liver and kidneys, alleviate damage induced by diabetes and oxidative stress, and inhibit Acr-induced liver and kidney cytotoxicity in rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Libor Vitek
Summary: The liver has evolved defense systems to protect against harmful stimuli, including antioxidant substances and enzymes, anti-inflammatory tools, enzymatic biotransformation systems, and metabolic pathways. Recent research indicates the significant role of the heme catabolic pathway in regulating the pathogenesis of liver and other diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Muhammad Ammar Zahid, Shahenda Salaheldin Abdelsalam, Hicham Raiq, Aijaz Parray, Hesham Mohamed Korashy, Asad Zeidan, Mohamed A. Elrayess, Abdelali Agouni
Summary: A timely and adequate response to stress is crucial for maintaining cell function, and disruptions in defense mechanisms against stress can lead to various pathologies. Aging and cardiovascular diseases can reduce the effectiveness of these defense mechanisms. Sestrin2 (SESN2) is a stress-inducible protein that can protect cells by increasing antioxidants, temporarily halting stressful reactions, and promoting autophagy. Maintaining sufficient levels/activity of SESN2 may prevent cardiovascular aging and disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Shimaa Khaled, Mirhan N. Makled, Manar A. Nader
Summary: Propolis extract has a protective potential against nicotine-induced pulmonary and hepatic damage, reducing oxidative stress and inflammation through activating the Nrf2/HO-1 signaling pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Food Science & Technology
Jing Yang, Huayi Suo, Jiajia Song
Summary: MitoQ reduces mitochondrial oxidative stress and promotes autophagy and mitochondrial biogenesis to alleviate MetS symptoms such as obesity, insulin resistance, hypertension, and cardiovascular disease. Its regulatory effect on mitochondrial homeostasis is mediated through AMPK and its downstream signaling pathways.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yaping Wang, Yi Wu, Mengen Xu, Muhammad Fakhar-e-Alam Kulyar, Mudassar Iqbal, Jingyi Wu, Xin Deng, Yaqiong Zhang, Bingtong Jiang, Mengmeng Hu, Yi Zhao, Kun Li, Yanyun Che
Summary: This study found that Emblica officinalis polysaccharide (EOP) can protect the liver against lead-induced injury and improve the negative changes in liver metabolic profile.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Zhiwei Huang, Yannan Shi, Hengcai Wang, Changju Chun, Longwang Chen, Kang Wang, Zhongqiu Lu, Yingzheng Zhao, Xinze Li
Summary: This study utilized chitosan-bilirubin nanoparticles to treat gastric ulcers through anti-inflammatory and antioxidant mechanisms, demonstrating their efficacy in in vitro and in vivo studies. The findings provide a novel approach for prophylaxis against or treatment of gastric ulcers.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Plant Sciences
Xiaofen Li, Jiyi Liang, Anquan Qin, Tao Wang, Sili Liu, Wei Li, Chuqiao Yuan, Liping Qu, Wenjun Zou
Summary: This study investigated the potential protective effect of DXXK against chronic cardiotoxicity induced by DOX. The results showed that DXXK could alleviate DOX-induced cardiotoxicity and reduce oxidative stress and inflammation by regulating HIF-1 alpha and NF-Kappa B p65.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Dan Liu, Xinyi Gu, Fang Han, Ming Cai, Weijie Liu, Li Han, Qiang Ma
Summary: The study showed that Ramelteon mitigated 6-OHDA-induced cellular senescence in SH-SY5Y neuronal cells by increasing Nrf2 expression. This effect may be achieved through inhibiting cell cycle arrest and reducing signs of cellular aging.
BRAIN AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Samrat Rakshit, Nisha Sahu, Satendra Kumar Nirala, Monika Bhadauria
Summary: The study found that purpurin has protective potential against acute hepatorenal injury, improving blood and tissue parameters and restoring the normal function of the liver and kidneys.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Environmental Sciences
Neici Caceres Silva, Marcia Rosula Poetini, Matheus Chimelo Bianchini, Francielli Polet Almeida, Mustafa Munir Mustafa Dahle, Stifani Machado Araujo, Vandreza Cardoso Bortolotto, Elize Aparecida Santos Musachio, Bruna Piaia Ramborger, Diogo La Rosa Novo, Rafael Roehrs, Marcia Foster Mesko, Marina Prigol, Robson Luiz Puntel
Summary: The study found that Ory can effectively protect flies from manganese poisoning and reduce the detrimental effects of manganese exposure. While Ory does not prevent manganese accumulation, it can prevent manganese-induced mortality and certain physiological and biochemical changes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Alica Navratilova, Marek Kovar, Jana Kopcekova, Jana Mrazova, Anna Trakovicka, Miroslava Pozgajova
Summary: This study found that acrylamide inhibits cell growth and causes oxidative stress in Schizosaccharomyces pombe, resulting in cell division arrest. However, supplementation with Aronia juice can alleviate the toxic effects of acrylamide by improving the antioxidant capacity and metabolic activity of cells. The protective effect of Aronia juice is dose-dependent, with a 2% solution showing higher cellular defense compared to a 1% solution.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2023)
Review
Nutrition & Dietetics
Bing Tan, Yuxi Wang, Xudong Zhang, Xiangjun Sun
Summary: Walnut kernels have anti-inflammatory effects and their long-term intake can improve memory and cognitive function. This review focuses on the regulation of neuroinflammation by walnuts and their active ingredients, as well as the potential development of walnut-based functional foods for neurodegenerative diseases.
Article
Chemistry, Applied
Lindauro C. Pereira Junior, Fernando G. Nascimento, Samara R. B. D. Oliveira, Glauber C. Lima, Francisco Diego S. Chagas, Venicios G. Sombra, Judith P. A. Feitosa, Eliane M. Soriano, Marcellus H. L. P. Souza, Guilherme J. Zocolo, Lorena M. A. Silva, Regina C. M. de Paula, Renan O. S. Damasceno, Ana Lucia P. Freitas
Summary: The study isolated and characterized a polysaccharide from the marine alga Acanthophora spicifera, which exhibited protective potential against chemically-induced gastric mucosa injury. The sulfated polysaccharide showed promising gastroprotective effects by preventing lipid peroxidation and enhancing the defense mechanisms of the gastric mucosa.
CARBOHYDRATE POLYMERS
(2021)
Review
Pharmacology & Pharmacy
Arsalan Ahmed, Shumaila Sarwar, Yong Hu, Muhammad Usman Munir, Muhammad Farrukh Nisar, Fakhera Ikram, Anila Asif, Saeed Ur Rahman, Aqif Anwar Chaudhry, Ihtasham Ur Rehman
Summary: The use of polymeric nanoparticles as drug carriers in cancer therapy is prevalent, but their distribution is hindered by physiological and cellular obstacles. This review emphasizes the importance of surface modification for controlling the fate of nanoparticles in the body, and discusses strategies to overcome these barriers to improve efficacy in cancer treatment.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Review
Medicine, Research & Experimental
Ahmad Ud Din, Maryam Mazhar, Muhammed Waseem, Waqar Ahmad, Asma Bibi, Adil Hassan, Niaz Ali, Wang Gang, Gao Qian, Razi Ullah, Tariq Shah, Mehraj Ullah, Israr Khan, Muhammad Farrukh Nisar, Jianbo Wu
Summary: The COVID-19 pandemic caused by the novel coronavirus has led to a global health crisis with diverse symptoms, including increased inflammation and gastrointestinal issues. As of now, there is no specific treatment for COVID-19, and researchers are actively searching for appropriate therapies and developing vaccines for prevention.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Maojiao Zhong, Yingying Wang, Farrukh Nisar Muhammad, Jing Gao, Chunxiang Bian
Summary: The p75(NTR) protein in melanoma cells exists in proteolytic fragments with opposite functions, regulating the balance between cell survival and death. Understanding the presence of these distinct fragments may have implications for better understanding the biological outcomes in tumor cells.
Review
Cell Biology
Vega Widya Karisma, Wei Wu, Mingxing Lei, Huawen Liu, Muhammad Farrukh Nisar, Matthew D. Lloyd, Charareh Pourzand, Julia Li Zhong
Summary: This review discusses the potential of UVA radiation as a light source for photo-controlled drug release, utilizing methods such as photo-isomerization and photo-cleavage to control drug release.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Integrative & Complementary Medicine
Guanzhen Wang, Junlong Wang, Wei Liu, Muhammad Farrukh Nisar, Mohamed A. El-Esawi, Chunpeng Wan
Summary: Plants of the genus Medicago have been found to contain a variety of saponins with diverse pharmacological and biological activities. Recent studies have shown the potential of Medicago-derived saponins in both modern and traditional medication systems, highlighting their antioxidant and antimicrobial properties. This information, along with data on the chemical structures and molecular masses of these saponins, can serve as a valuable starting point for further research on the therapeutic potential of this important genus.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mei Wang, Mingxing Lei, Li Chang, Yang Xing, Yingying Guo, Charareh Pourzand, Joerg W. Bartsch, Jingyi Chen, Jiefu Luo, Vega WidyaKarisma, Muhammad Farrukh Nisar, Xia Lei, Julia Li Zhong
Summary: The research demonstrates that Bach2 modulates the extent of autophagy in skin fibroblasts, thereby affecting UVA-induced cell senescence. Knockdown of Bach2 increases the expression of cell senescence-related genes, exacerbating the photoaging process, while overexpression of Bach2 has the opposite effect.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Muhammad Farrukh Nisar, Maryam Yousaf, Muhammad Saleem, Hamad Khalid, Kamal Niaz, Mustansara Yaqub, Muhammad Yasir Waqas, Arsalan Ahmed, Muhammad Abaid-Ullah, Jinyin Chen, Chuying Chen, Kannan R. R. Rengasamy, Chunpeng (Craig) Wan
Summary: This study focused on the preparation of quercetin-loaded zinc oxide nanoparticles (quercetin@ZnO NPs) and their potential in preventing photoaging by analyzing their cellular iron sequestration ability and antioxidant properties. The results demonstrated that these nanoparticles showed no cytotoxic effects on human HaCaT cells, and exhibited excellent antioxidant, anti-inflammatory, and iron sequestration potential, making them a promising candidate for antiphotoaging therapeutics.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Cell Biology
Muhammad Farrukh Nisar, Mahnoor Khadim, Muhammad Rafiq, Jinyin Chen, Yali Yang, Chunpeng Craig Wan
Summary: Biologically active phytochemicals sourced from important plants are beneficial in pharmaceuticals, particularly in preventing inflammatory diseases. Eugenol, a versatile natural molecule found in various plant species, has significant industrial applications and health benefits.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Muhammad Farrukh Nisar, Tiantian Liu, Mei Wang, Shida Chen, Li Chang, Vega Widya Karisma, Weixu, Qingchun Diao, Mei Xue, Xueyong Tang, Charareh Pourzand, Jing Yang, Julia Li Zhong
Summary: Eriodictyol significantly reduces UVA-induced ROS generation and MMP-1 expression, leading to decreased inflammatory responses and increased expression of TIMP-1 and COL-1. These findings demonstrate that eriodictyol has strong anti-inflammatory and antiphotoaging effects.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Muhammad Yasir Waqas, Muhammad Arshad Javid, Muhammad Mudasser Nazir, Nasir Niaz, Muhammad Farrukh Nisar, Zahid Manzoor, Sheraz Ahmed Bhatti, Sajid Hameed, Muhammad Haseeb Khaliq
Summary: This article discusses the mechanisms of extracellular vesicle biogenesis and their role in cellular signaling, emphasizing their importance as biomarkers in certain pathologies. The article also examines the packaging and delivery of proteins, RNA, and lipids by extracellular vesicles and their potential as non-invasive biomarkers in clinical disorders.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Cell Biology
Zhiguo Shan, Muhammad Farrukh Nisar, Mingxi Li, Chunhua Zhang, Chunpeng (Craig) Wan
Summary: TFs in black tea, particularly TF3, exhibit significant health benefits including anti-inflammatory, antioxidant, anticancer, antiobesity, antiosteoporotic, and antimicrobial properties, which have a significant impact on human health. Studies have shown that TFs play a crucial role in modulating health effects through cellular and molecular mechanisms.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Biotechnology & Applied Microbiology
Sarfraz Ahmed, Muhammad Ibrahim, Chanin Nantasenamat, Muhammad Farrukh Nisar, Aijaz Ahmad Malik, Rashem Waheed, Muhammad Z. Ahmed, Suvash Chandra Ojha, Mohammad Khursheed Alam
Summary: DNA barcoding is a widely used technology for species identification in various organisms. It serves as a hereditary succession code, enabling the recognition and resolution of different biological issues. Although specific markers are used for identifying different organisms, the taxon coverage of reference sequences is still incomplete. The application of next-generation sequencing methods can greatly expand the potential of this technology in biodiversity research.
BIOMED RESEARCH INTERNATIONAL
(2022)
Editorial Material
Integrative & Complementary Medicine
Chunpeng (Craig) Wan, Muhammad Farrukh Nisar, Hua Wu
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Medicine, Research & Experimental
Liangliang Yao, Wei Liu, Mariam Bashir, Muhammad Farrukh Nisar, Chunpeng (Craig) Wan
Summary: Eriocitrin, found in citrus fruits like lemon, has potent biological actions including strong antioxidant effects, making it more effective in suppressing oxidative stress in diabetes and other chronic diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)