Article
Agriculture, Dairy & Animal Science
J. Alberto Gines
Summary: This study provides initial information on the effect of platelet rich plasma on the most important pro-inflammatory cytokines in dogs with osteoarthritic joint. The results suggest that LrPRP can modulate the ratios of pro-inflammatory cytokine TNF-alpha in dogs with CCLR.
Article
Agriculture, Dairy & Animal Science
Guillaume Domain, Justyna Buczkowska, Patrycja Kalak, Eline Wydooghe, Penelope Banchi, Osvaldo Bogado Pascottini, Wojciech Nizanski, Ann Van Soom
Summary: This study investigated the relationship between blood serum Anti-Mullerian hormone (AMH) concentration and semen quality in dogs. Moderate negative associations were found between serum AMH and semen total motility, progressive motility, and normal morphology, suggesting that high serum AMH may be a potential biomarker for identifying dogs that would require further semen investigation. An optimal cut-off point value of 5.54 μg/L for serum AMH was determined to have the greatest sensitivity and specificity in predicting semen quality. Future research is needed to confirm these preliminary results.
Review
Biochemistry & Molecular Biology
Chen Yu, Bing Zhao, Yan Li, Hengchang Zang, Lian Li
Summary: This review discusses the current research status of osteoarthritis (OA), the importance of early diagnosis, the potential application of vibrational spectroscopy in OA diagnosis, comparison of various diagnostic methods, and the promising role of vibrational spectroscopy as a tool for early OA diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Chemical
Atiqah Ab Aziz, Veenesh Selvaratnam, Yasmin Fadzlin Binti Ahmad Fikri, Muhamad Shirwan Abdullah Sani, Tunku Kamarul
Summary: The present study aimed to develop a rapid non-destructive detection method for early diagnosis of osteoarthritis (OA) through evaluating infrared spectroscopy combined chemometrics. The results showed that ATR-FTIR spectroscopy combined with chemometrics analysis could detect spectral biomarkers for discriminating OA patients, providing a rapid and cost-effective blood test for early diagnosis of human OA.
Article
Veterinary Sciences
Ji-Seon Yoon, DoHyeon Yu, Jinho Park
Summary: This study identified changes in the serum protein profile in dogs with pyometra using serum protein electrophoresis, finding decreased levels of albumin and elevated levels of alpha 2-globulin and beta-globulin. Additionally, concentrations of acute phase proteins (CRP, SAA, and Hp) were also elevated in dogs with pyometra, providing fundamental data for inflammatory indicators of this condition.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Health Care Sciences & Services
Charlotte Delrue, Sander De Bruyne, Marijn M. M. Speeckaert
Summary: Infrared (IR) spectroscopy is a noninvasive and rapid analytical technique that provides information on the chemical composition, structure, and conformation of biomolecules in saliva. It has been widely used to analyze salivary biomolecules due to its label-free advantages. Saliva contains a complex mixture of biomolecules that can serve as potential biomarkers for various diseases, and IR spectroscopy has shown great promise in their diagnosis and monitoring. Recent advancements in IR spectroscopy, such as FTIR and ATR spectroscopy, have further improved its utility in salivary analysis.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Veterinary Sciences
Mehmet Maden, Erdem Gulersoy
Summary: This study aimed to evaluate the diagnostic efficacies of selected inflammatory and intestinal biomarkers in cases of infectious and non-infectious diarrhea in dogs. The results showed that S100A12 and CRP concentrations have diagnostic values in viral diarrhea, while LCTF concentrations have diagnostic values in bacterial diarrhea.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Veterinary Sciences
Nadav Yair, Christos Yiapanis, Ron Ben-Amotz, Joshua Milgram
Summary: This study aimed to describe the passive movement of the tibia relative to the femur in dogs, with the hind limb in different orientations, and with the cranial cruciate ligament (CCL) intact and cut. The results showed that cutting the CCL did not significantly affect the translation and rotation of the tibia when the stifle was oriented to approximate the standing position of a dog.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Sophie Palierne, Margaux Blondel, Kevin Vie, Andre Autefage
Summary: This study provides a morphometric assessment of the medial collateral ligament (MCL) of the canine stifle joint. The results show that the MCL has insertion sites on the femur and tibia and is intimately attached to the medial meniscus. The location of the MCL insertion site appears to be relatively homogeneous in dogs.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Medicine, General & Internal
Marek Lacko, Denisa Harvanova, Lucia Slovinska, Martin Matuska, Marek Balog, Antonia Lackova, Timea Spakova, Jan Rosocha
Summary: The study found that intra-articular PRP injections significantly improved pain and functional status in knee osteoarthritis patients. PRP treatment increased levels of specific pro-anabolic and anti-inflammatory biomarkers, while decreasing levels of pro-inflammatory biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Veterinary Sciences
Annkathrin Estaller, Martin Kessler, Axel Wehrend, Frank Gessler, Johannes Hirschberger, Stephan Neumann
Summary: This study found that serum survivin concentrations in dogs with malignant tumors were significantly higher than in healthy dogs and dogs with non-neoplastic diseases, suggesting that survivin may be a potential tumor marker in dogs.
JOURNAL OF VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Annkathrin Estaller, Martin Kessler, Axel Wehrend, Johannes Hirschberger, Stephan Neumann
Summary: This study aimed to determine whether Ki-67 could be considered as a potential serum tumour marker in veterinary medicine. The results showed significantly higher serum Ki-67 concentrations in dogs with malignant tumours compared to healthy dogs and dogs with non-malignant diseases. No significant difference in serum Ki-67 concentration was observed between different types of cancer or between benign and malignant mammary tumours. This suggests that Ki-67 may be useful as a serum tumour marker for detecting malignancies in dogs.
Article
Chemistry, Analytical
Samantha H. Rutherford, Christopher D. M. Hutchison, Gregory M. Greetham, Anthony W. Parker, Alison Nordon, Matthew J. Baker, Neil T. Hunt
Summary: The study demonstrates that ultrafast 2D-IR spectroscopy can directly measure protein-drug binding in blood serum samples, enabling the detection and differentiation of drug-containing samples and providing structural insight and quantitative information on protein-drug binding.
ANALYTICAL CHEMISTRY
(2023)
Review
Veterinary Sciences
Monika Anna Mille, Jamie McClement, Susanne Lauer
Summary: Osteoarthritis (OA) is a chronic disease that requires lifelong therapy in dogs. Physiotherapy plays an important role in reducing pain and improving mobility and quality of life. The authors propose a simple systematic approach, known as the Physiotherapy Pyramid, that prioritizes measures based on simplicity, cost effectiveness, and practicality to effectively manage canine OA.
VETERINARY SCIENCES
(2023)
Article
Medicine, Research & Experimental
YaGuang Han, Jun Wu, ZhenYu Gong, YiQin Zhou, HaoBo Li, Bo Wang, QiRong Qian
Summary: The study found that the immune score in OA samples was significantly higher than in normal samples. Through WGCNA, a co-expression module positively correlated with OA was identified, and 5 final hub genes were discovered. A diagnostic model based on these 5 genes showed good performance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Veterinary Sciences
C. B. Riley, H. Pfeffer, C. MacLachlan, L. Wakeford, I. R. Gibson, J. Benschop, K. E. Lawrence
Summary: This study described the bacterial species, antimicrobial susceptibility, and multidrug resistance in sheep samples submitted to veterinary diagnostic labs in New Zealand between 2003 and 2016. The most commonly isolated bacteria were Salmonella, Campylobacter, Listeria, and Yersinia, with varying levels of susceptibility to fluoroquinolones and tetracyclines. Multidrug resistance was found in a subset of isolates, with differences between bacterial species.
NEW ZEALAND VETERINARY JOURNAL
(2021)
Article
Veterinary Sciences
C. B. Riley, E. D. Aldrich, S. L. Pemberton, A. A. Mirza
Summary: A 9-year-old warmblood gelding presented with chronic respiratory signs was diagnosed with infectious bronchopneumonia associated with Nicoletella semolina. Treatment with antimicrobials led to improvement in clinical signs and the horse recovered without further complications.
NEW ZEALAND VETERINARY JOURNAL
(2021)
Article
Agriculture, Dairy & Animal Science
Christopher B. Riley, Kirsty L. Chidgey, Janis P. Bridges, Emma Gordon, Kevin E. Lawrence
Article
Multidisciplinary Sciences
Sarah Malek, Hsin-Yi Weng, Shannon A. Martinson, Mark C. Rochat, Romain Beraud, Christopher B. Riley
Article
Veterinary Sciences
Dirsko J. F. von Pfeil, Sara Megliolia, Sarah Malek, Mark Rochat, Mathieu Glassman
Summary: This retrospective study evaluated the clinical experience of fluoroscopically guided tibial apophyseal percutaneous pinning (TAPP) for tibial tuberosity avulsion fractures (TTAF) in 25 skeletally immature dogs. The results showed that TAPP can be considered an effective treatment for TTAF, with factors such as pin design, insertion angles, and monitoring tibial plateau angle playing important roles in improving outcomes for TTAF patients. Long-term follow-up showed excellent results in all cases.
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Francesca Dai, Martina Zappaterra, Michela Minero, Francesca Bocchini, Christopher B. Riley, Barbara Padalino
Summary: The study identified factors such as the use of sedation and whips for loading, lack of vehicle brake checks, and vehicle design as major risk factors for equine transport-related injuries and problem behaviors. Educating industry members on best practices to minimize transport-related problems is crucial for safeguarding the well-being of horses and handlers.
Article
Orthopedics
Seth A. Herr, Sarah Malek, Mark C. Rochat, George E. Moore, Jeff C. Ko, Riyi Shi
Summary: This study confirmed the presence of acrolein in the synovial fluid of dogs with osteoarthritis. Freezing synovial fluid for up to 5 years did not significantly affect the detection of acrolein-lysine adduct and MMP2 in the samples.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Agriculture, Dairy & Animal Science
Christopher B. Riley, Chris W. Rogers, Kirrilly R. Thompson, Danielle Guiver, Barbara Padalino
Summary: This study examines the injuries sustained by horses during road transport in New Zealand and identifies the factors associated with these injuries. The findings highlight the significant incidence of injury and related death during horse transport by road in New Zealand and the key risk factors involved.
Article
Orthopedics
Hassan Farooq, Robert P. Wessel, Krista M. Brown, James E. Slaven, Federico Marini, Sarah Malek, Roman M. Natoli
Summary: This study compares plasma protein inflammatory biomarkers and mid-infrared spectral patterns in patients with fracture-related infections and controls without infection. The results suggest that both enzyme-linked immunosorbent assay-based biomarkers and MIR spectra may be used as potential clinical tools for diagnosing fracture-related infections. Further investigation is needed in larger patient cohorts.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Veterinary Sciences
Kenneth J. Brand, Sarah Malek, Audrey Ruple, G. Kenitra Hendrix
Summary: The objective of this study was to determine the frequency of positive cultures of surgical gown cuffs among scrubbed personnel in orthopaedic surgical procedures on client-owned dogs. The study found that humidity in the operating room and the number of individuals scrubbed into surgery had a significant effect on the likelihood of positive culture after surgery. One dog developed osteomyelitis.
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Luca Panizzi, Keren E. Dittmer, Matthieu Vignes, Jennie S. Doucet, Kristene Gedye, Mark R. Waterland, Chris W. Rogers, Hiroki Sano, C. Wayne McIlwraith, Christopher B. Riley
Summary: This study aimed to determine if the measurement of cell-free DNA could be used for the early diagnosis of osteoarthritis in horses. Osteoarthritis was induced in some horses, and joint fluid and plasma samples were collected for measurement. The results showed that the concentration of cell-free DNA in joint fluid was significantly higher in horses with osteoarthritis compared to the control group, but there were no significant differences in plasma cell-free DNA concentrations. Measurement of cell-free DNA in joint fluid may be useful for early diagnosis of osteoarthritis in horses.
Article
Agriculture, Dairy & Animal Science
Christopher B. Riley, Barbara Padalino, Chris W. Rogers, Kirrilly R. Thompson
Summary: There is an increased understanding of shared human-animal risk in terms of one welfare, whereby when animals are at risk, so are people, so preventing injury to one species may also prevent injury to the other. This study aimed to determine the frequency and associated factors of road equine transport-related injuries to humans in New Zealand. The results showed that 10.5% of horse industry participants experienced injuries while preparing, loading, traveling, or unloading horses, with hand injuries being the most common. Wearing helmets and gloves, and adopting strategies to eliminate equine injuries are recommended to reduce the risk of injury to horse handlers during road transport.
Meeting Abstract
Orthopedics
S. Malek, H. -Y. Weng, C. B. Riley
OSTEOARTHRITIS AND CARTILAGE
(2020)