Journal
ORGANIC LETTERS
Volume 21, Issue 23, Pages 9326-9329Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03396
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Funding
- National Natural Science Foundation (NSF) of China [21572203, 21472140]
- NSF of Zhejiang Province [LZ16B020001]
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A simple protocol for the synthesis of difluoromethylthiolated chromen-4-ones using elemental sulfur and CICF2CO2Na as the difluoromethylthiolating agent is described. Three-component reactions of 2'-hydroxychalcones, CICF2CO2Na, and sulfur under basic conditions using TEMPO as the oxidant afforded HCF2S-containing 4H-chromen-4-one and 9H-thieno[3,2-b]chromen-9-one derivatives in good yield. The protocol is practical and efficient, and the starting materials are cheap and readily available.
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