Article
Chemistry, Physical
Klaudia Karkeszova, Maria Mastihubova, Vladimir Mastihuba
Summary: The study demonstrates that kojic acid esters can be produced by various enzymes with different regioselectivity, with pig pancreatic lipase showing distinct stereo selectivity in the reaction.
Article
Biochemistry & Molecular Biology
Kozue Sakao, Hanako Saruwatari, Shohei Minami, De-Xing Hou
Summary: This study demonstrates that acetylation of quercetin enhances its antitumor effects on HepG2 cells, leading to increased apoptosis, protein activation, and mitochondrial membrane disruption. The acetylated quercetin is also more readily absorbed and metabolized in the cells compared to the parent quercetin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Mingwu Yu, Zheng Zhou, Chunhui Zou, Zhichuan Wang, Weili Wang, Kai Sun
Summary: A highly regioselective radical reaction, aided by traceless H+, has been developed for the synthesis of C-6-acylated purines and purine nucleosides. This reaction is performed at room temperature within a short time period of 10 minutes. It offers excellent functional group compatibility, a broad substrate scope, and good C-6-regioselectivity. The use of H+ is environmentally friendly and does not require additional functional group modification.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemistry & Molecular Biology
Yunyun Zheng, Jiuling Li, Kai Wei
Summary: An efficient, high-yielding, and scalable method for the regioselective 3-acylation of indoles with anhydrides promoted by boron trifluoride etherate under mild conditions was reported. This novel protocol provides a simple way to prepare 3-(benzofuran-2-yl) indole in three steps.
Article
Chemistry, Multidisciplinary
Jaan Parve, Marina Kudryasova, Tatsiana Shalima, Ly Villo, Ilme Liblikas, Indrek Reile, Tonis Pehk, Nicholas Gathergood, Riina Aav, Lauri Vares, Omar Parve
Summary: The study presents a simple synthesis method for 4-(acyloxy)pentanoic acids from gamma-valerolactone, producing high enantiomeric excess products that stimulate the development of novel applications, including biobased isotactic polymers.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Organic
Iryna Vashchenko, Mariya Veselovska, Grygoriy A. Dolgonos, Oleg Lukin, Alexey Poyarkov, Tetyana Kiyenko, Martin E. Gleave, Volodymyr Fetyukhin, Alexander Shivanyuk, Francesco Gentile, Artem Cherkasov
Summary: This study achieved absolutely selective monoacylation of the 5-hydroxyl group on the macrocyclic skeleton by reacting abamectin and ivermectin aglycones with acid chlorides, succinic anhydride, or aryl isocyanates. The synthesis of diesters with different acyloxy fragments in positions 5 and 13 was also achieved. Theoretical studies provided insight into the higher reactivity of the 5-hydroxyl group and the stabilization of intermediate and transition state structures.
Article
Chemistry, Physical
Xiaoxu Yang, Yan Zhang, Huimin Pang, Sheng Yuan, Xuxia Wang, Zhiming Hu, Qinghua Zhou, Yaojia He, Yunjun Yan, Li Xu
Summary: The study successfully produced biodiesel from tallow seed oil by codisplaying CRL1 and ROL on the cell surfaces of P. pastoris whole-cell catalysts. The activity of codisplaying strains was significantly higher than that of single-displayed enzymes, and using codisplayed enzymes for catalysis can increase the production of methyl esters.
Article
Chemistry, Organic
Naoyuki Shimada, Tomoya Sugimoto, Mao Noguchi, Chikako Ohira, Yutaro Kuwashima, Naoya Takahashi, Noriko Sato, Kazuishi Makino
Summary: The study presents boronic acid-catalyzed regioselective Koenigs-Knorr-type glycosylation, demonstrating for the first time the use of a boronic acid catalyst to selectively glycosylate cis-vicinal diols in glycosyl acceptors, enabling efficient construction of 1,2-trans glycosidic linkage.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Taeok Kim, Michael R. Bell, V. Narasimharao Thota, Todd L. Lowary
Summary: This study reports a one-pot strategy for functionalizing pyranoside 1,2-cis-diols with two different ester protecting groups. The approach selectively acylates through orthoester hydrolysis promoted by a carboxylic acid, and after removal of water and introduction of a coupling agent, the carboxylic acid is esterified with the liberated hydroxyl group. Although applied to 1,2-cis-diols on pyranoside scaffolds, this method can be applicable to similar motifs on any six-membered ring.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Koen Adriaensen, Jannick Vercammen, Cedric Van Goethem, Kumar Varoon Agrawal, Dirk De Vos
Summary: In this study, a chemoenzymatic dynamic kinetic resolution (DKR) method for beta-amino esters was established through the evaluation of metal-based heterogeneous catalysts for racemization and enzyme catalysts for kinetic resolution. By selecting two promising racemization catalysts, the researchers established a relationship between catalyst characteristics and reaction selectivities, and achieved efficient DKR with excellent enantioselectivity.
CATALYSIS SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Organic
Yixuan Zhou, Kuo-Shiang Liao, Tzu-Yin Chen, Yves S. Y. Hsieh, Chi-Huey Wong
Summary: The regioselective functionalization of unprotected carbohydrates at a secondary OH group has been improved by using the commonly used organotin-mediated reaction. By preactivating the dibutylstannylene acetal intermediate with tetrabutylammonium bromide in toluene, efficient, high-yielding, and regioselective tosylation, benzoylation, or benzylation of unprotected carbohydrates can be achieved. The counteranion of tetrabutylammonium ion with a weak coordination ability plays a crucial role in the improved regioselective reactions. Additionally, the organotin-mediated regioselective tosylation of unprotected carbohydrates followed by nucleophilic inversion reaction allows convenient access to intermediates of synthetic value, such as sulfur-containing and azide-modified carbohydrates.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Microbiology
Qinghua Li, Jinchang Lu, Guoqiang Zhang, Jingwen Zhou, Jianghua Li, Guocheng Du, Jian Chen
Summary: In this study, high-efficiency transformation of Aspergillus oryzae was achieved by optimizing the preparation conditions of protoplasts, and random editing of single and double genes using the CRISPR/Cas9 system reached 37.6% and 19.8% efficiency, respectively. With the aid of selection markers, such as color or resistance, the editing efficiency of single and double genes could reach 100%. The development of this system improves the efficiency of transformation and multiplexed genome editing for A. oryzae, providing a practical method for developing a high-efficiency expression system for heterologous proteins.
Article
Engineering, Chemical
Song Zhu, Baoshuang Du, Dejian Huang, Yongmei Xia, Shangwei Chen, Yue Li
Summary: This study aimed to improve the liposolubility of dihydromyricetin (DHM) through enzymatic acylation, resulting in increased antioxidant activities for DHM derivatives with different substituted carbon chain lengths.
Article
Chemistry, Medicinal
Eduardo Padilla-Camberos, Javier Arrizon, Georgina Sandoval
Summary: This study evaluated the effects of agave fructan bioconjugates in a rat model with metabolic syndrome. The results showed that the bioconjugates of agave fructans with laurate significantly decreased glucose levels, systolic pressure, weight gain, and visceral adipose tissue, while also inhibiting pancreatic lipase. These findings demonstrate the potential of agave bioconjugates, particularly laurate bioconjugates, for preventing diseases associated with metabolic syndrome.
Article
Food Science & Technology
Jingxue Liu, Tingting Gao, Jiaying Xin, Chungu Xia
Summary: In this study, starch ferulate was synthesized using a mechanoenzymatic method, and optimal conditions were determined through process optimization. The research revealed that the mechanoenzymatic method can increase the specific surface area of starch molecules, facilitating the exposure of active sites. This breakthrough highlights the potential of mechanoenzymatic techniques in improving the synthesis of starch ferulate.
Article
Agricultural Engineering
Firdaus Jahan, Vinod Kumar, R. K. Saxena
BIORESOURCE TECHNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Firdaus Jahan, Vinod Kumar, Garima Rawat, R. K. Saxena
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2012)
Article
Agricultural Engineering
Richi V. Mahajan, Saurabh Saran, Karthikeya Kameswaran, Vinod Kumar, R. K. Saxena
BIORESOURCE TECHNOLOGY
(2012)
Article
Biotechnology & Applied Microbiology
Vinod Kumar, Firdaus Jahan, Shailendra Raghuwanshi, Richi V. Mahajan, Rajendra Kumar Saxena
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2013)
Article
Biotechnology & Applied Microbiology
Vinod Kumar, Firdaus Jahan, Karthikeya Kameswaran, Richi V. Mahajan, Rajendra Kumar Saxena
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Anu Arya, Divya Mathur, Abhilash Tyagi, Rajesh Kumar, Vinod Kumar, Carl E. Olsen, Rajendra K. Saxena, Ashok K. Prasad
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2013)
Article
Multidisciplinary Sciences
Richi V. Mahajan, Vinod Kumar, Vinoth Rajendran, Saurabh Saran, Prahlad C. Ghosh, Rajendra Kumar Saxena
Article
Biochemical Research Methods
Vinod Kumar, Sweta Yadav, Firdaus Jahan, Rajendra Kumar Saxena
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2014)
Article
Agricultural Engineering
Yinping Xiang, Meiying Jia, Rui Xu, Jialu Xu, Lele He, Haihao Peng, Weimin Sun, Dongbo Wang, Weiping Xiong, Zhaohui Yang
Summary: This study investigated the impact of the non-antibiotic pharmaceutical carbamazepine on antibiotic resistance genes (ARGs) during anaerobic digestion. The results showed that carbamazepine induced the enrichment of ARGs and increased the abundance of bacteria carrying these genes. It also facilitated microbial aggregation and intercellular communication, leading to an increased frequency of ARGs transmission. Moreover, carbamazepine promoted the acquisition of ARGs by pathogens and elevated their overall abundance.
BIORESOURCE TECHNOLOGY
(2024)
Review
Agricultural Engineering
Weixin Zhao, Tianyi Hu, Hao Ma, Dan Li, Qingliang Zhao, Junqiu Jiang, Liangliang Wei
Summary: This review summarizes the effects and potential mechanisms of biochar on microbial behavior in AD systems. The addition of biochar has been found to promote microbial colonization, alleviate stress, provide nutrients, and enhance enzyme activity. Future research directions include targeted design of biochar, in-depth study of microbial mechanisms, and improved models.
BIORESOURCE TECHNOLOGY
(2024)
Review
Agricultural Engineering
Christina Karmann, Anna Magrova, Pavel Jenicek, Jan Bartacek, Vojtech Kouba
Summary: This review assesses nitrogen removal technologies in reject water treatment, highlighting the differences in environmental impacts and economic benefits. Partial nitritation-anammox shows potential for economic benefits and positive environmental outcomes when operated and controlled properly.
BIORESOURCE TECHNOLOGY
(2024)
Article
Agricultural Engineering
Wei-Hao Huang, Ying-Ju Chang, Duu-Jong Lee
Summary: This study modified pinecone biochar with layered double hydroxide (LDH) to enhance its adsorption capacity for heavy metal and phosphate ions. The LDH-biochar showed significantly improved adsorption capacities for Pb2+ and phosphate, and a slight increase for Cu2+ and Co2+. The LDH layer enhanced the adsorption through various mechanisms.
BIORESOURCE TECHNOLOGY
(2024)
Article
Agricultural Engineering
Chao Song, Fanfan Cai, Shuang Yang, Ligong Wang, Guangqing Liu, Chang Chen
Summary: This paper developed a machine learning model to predict the biochemical methane potential during anaerobic digestion. Model analysis identified lignin content, organic loading, and nitrogen content as key attributes for methane production prediction. For feedstocks with high cellulose content, early methane production is lower but can be improved by prolonging digestion time. Moreover, lignin content exceeding a certain value significantly inhibits methane production.
BIORESOURCE TECHNOLOGY
(2024)
Article
Agricultural Engineering
Sang Min Lee, Ju Young Lee, Ji-Sook Hahn, Seung-Ho Baek
Summary: This study successfully developed an efficient platform strain using Yarrowia lipolytica for the bioconversion of renewable resources into adipic acid, achieving a remarkable increase in production level.
BIORESOURCE TECHNOLOGY
(2024)
Article
Agricultural Engineering
Sefkan Kendir, Matthias Franzreb
Summary: This study presents a novel approach using magnetic separation to efficiently harvest freshwater microalgae, Chlorella vulgaris. By combining pH-induced calcium phosphate precipitation with cheap natural magnetite microparticles, harvesting efficiencies up to 98% were achieved in the model medium.
BIORESOURCE TECHNOLOGY
(2024)
Article
Agricultural Engineering
Ishaq Kariim, Ji-Yeon Park, Wajahat Waheed Kazmi, Hulda Swai, In-Gu Lee, Thomas Kivevele
Summary: The impact of reaction temperature, residence time, and ethanol: acetone on the energy compositions and yield enhancement of biocrudes was investigated. The results showed that under appropriate conditions, biocrudes with high energy and low oxygen content can be obtained, indicating a high potential for utilization.
BIORESOURCE TECHNOLOGY
(2024)
Article
Agricultural Engineering
Xiyue Zhang, Xiyao Li, Liang Zhang, Yongzhen Peng
Summary: Intermittent aeration is an innovative approach to enhance nitrogen removal in low carbon-to-nitrogen ratio municipal sewage, providing an efficient strategy for the continuous plug-flow AOA process.
BIORESOURCE TECHNOLOGY
(2024)
Article
Agricultural Engineering
Xu Yang, Mahmoud Mazarji, Mengtong Li, Aohua Li, Ronghua Li, Zengqiang Zhang, Junting Pan
Summary: This study investigated the impact of magnetite on the nitrogen cycle of pig manure biostabilisation. The addition of magnetite increased N2O emissions and decreased NH3 emissions during composting. It also increased the total nitrogen content but should be considered for its significant increase in N2O emissions in engineering practice.
BIORESOURCE TECHNOLOGY
(2024)
Review
Agricultural Engineering
Ty Shitanaka, Haylee Fujioka, Muzammil Khan, Manpreet Kaur, Zhi-Yan Du, Samir Kumar Khanal
Summary: The market value of microalgae has exponentially increased in the past two decades, thanks to their applications in various industries. However, the supply of high-value microalgal bioproducts is limited due to several factors, and strategies are being explored to overcome these limitations and improve microalgae production, thus increasing the availability of algal-derived bioproducts in the market.
BIORESOURCE TECHNOLOGY
(2024)
Article
Agricultural Engineering
Martin Kerner, Thorsten Wolff, Torsten Brinkmann
Summary: The efficiency of using enriched CO2 from flue gas for large-scale production of green microalgae has been studied. The results show that the use of membrane devices and static mixers can effectively improve the CO2 recovery rate and maintain the suitable pH and temperature during cultivation, achieving a more economical and sustainable microalgae production.
BIORESOURCE TECHNOLOGY
(2024)
Article
Agricultural Engineering
Rui Ma, Ji Li, Rd Tyagi, Xiaolei Zhang
Summary: This review summarizes the microorganisms capable of using CO2 and CH4 to produce PHAs, illustrating the production process, factors influencing it, and discussing optimization techniques. It identifies the challenges and future prospects for developing economically viable PHAs production using GHGs as a carbon source.
BIORESOURCE TECHNOLOGY
(2024)
Article
Agricultural Engineering
Bing Wang, Peng Zhang, Xu Guo, Xu Bao, Junjie Tian, Guomin Li, Jian Zhang
Summary: The addition of zeolite in the co-composting of chicken manure and straw significantly reduced the emissions of ammonia and N2O, and increased the nitrate content. Zeolite also promoted the abundance of nitrification genes and inhibited the expression of denitrification genes.
BIORESOURCE TECHNOLOGY
(2024)
Article
Agricultural Engineering
Rohit Dey, Franziska Ortiz Tena, Song Wang, Josef Martin Messmann, Christian Steinweg, Claudia Thomsen, Clemens Posten, Stefan Leu, Matthias S. Ullrich, Laurenz Thomsen
Summary: This study investigated the operation of a 1000L microalgae-based membrane photobioreactor system for continuous secondary wastewater treatment. The research focused on a green microalgae strain called Desmodesmus sp. The study aimed to understand key trends and optimization strategies by conducting experiments in both summer and winter seasons. The findings showed that maintaining low cell concentrations during periods of light inhibition was beneficial for nutrient uptake rates. Effective strategies for enhancing algae-based wastewater treatment included cell mass recycling and adjusting dilution rates based on light availability.
BIORESOURCE TECHNOLOGY
(2024)