Review
Biochemistry & Molecular Biology
Paula Silva, Maria Rodriguez-Perez, Emma Burgos-Ramos
Summary: This review explores the potential of a zebrafish model in investigating the antioxidant effects of olive oil and wine, which are key components of the Mediterranean diet, in preventing age-related diseases, particularly cardiovascular conditions. The review highlights the genetic proximity of zebrafish to humans, offering a unique opportunity for translational insights into the health benefits of olive oil and wine.
Article
Oncology
Enrique Almanza-Aguilera, Ainara Cano, Mercedes Gil-Lespinard, Nerea Burguera, Raul Zamora-Ros, Antonio Agudo, Marta Farras
Summary: Olive oil is the main source of added fat in the Mediterranean diet, and it has been shown to improve obesity-related factors. However, the relationship between Mediterranean diet, olive oil, and obesity-related cancers, as well as the underlying mechanisms, are not well understood.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Oncology
Marta Farras, Enrique Almanza-Aguilera, Alvaro Hernaez, Nuria Agusti, Josep Julve, Montserrat Fito, Olga Castaner
Summary: Virgin olive oil is a key component of the Mediterranean diet, containing a variety of beneficial health compounds. Consumption of olive oil has been linked to improvements in human health and reduced risk of cancer.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Nutrition & Dietetics
Diana C. Mantilla-Escalante, Maria-Carmen Lopez De las Hazas, M. Carmen Crespo, Roberto Martin-Hernandez, Joao Tome-Carneiro, Lorena Del Pozo-Acebo, Jordi Salas-Salvado, Monica Bullo, Alberto Davalos
Summary: This study aimed to characterize the modulation of exosomal lncRNAs, mRNAs and miRNAs after a 1-year adherence to different diets. Results showed that Mediterranean diets enriched with nuts or extra-virgin olive oil significantly altered exosomal RNA content compared to a low-fat diet, with implications on metabolic pathways. Further investigation into the impact of exosomal RNAs from dietary interventions is warranted.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Carolina Donat-Vargas, Esther Lopez-Garcia, Jose R. Banegas, Miguel A. Martinez-Gonzalez, Fernando Rodriguez-Artalejo, Pilar Guallar-Castillon
Summary: The study found that moderate daily consumption of virgin olive oil is associated with a lower risk of all-cause and cardiovascular mortality, while common olive oil does not show the same effect.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Ioanna Yiannakou, Martha R. Singer, Paul F. Jacques, Vanessa Xanthakis, R. Curtis Ellison, Lynn L. Moore
Summary: This study found that adherence to a Mediterranean-style diet is associated with a lower cancer risk, especially among women. Moderate or higher adherence to the MSDP can significantly decrease the risk of cancer.
Review
Biochemistry & Molecular Biology
Renata Riolo, Riccardo De Rosa, Irene Simonetta, Antonino Tuttolomondo
Summary: Human nutrition is a new science based on biochemistry and the effects of food constituents. Ancient medicine believed in the medicinal properties of food, with Hippocrates stating that a balanced diet could help maintain health. Understanding molecular nutrition and the interaction between nutrients and DNA can lead to the formulation of diets where food acts as both food and medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Adrian Carballo-Casla, Esther Garcia-Esquinas, Esther Lopez-Garcia, Mercedes Sotos-Prieto, Ellen A. Struijk, Francisco Felix Caballero, Fernando Rodriguez-Artalejo, Rosario Ortola
Summary: The study found that increased consumption of fried food in a Mediterranean country was associated with delayed unhealthy aging. Olive oil and fried protein-rich foods were the main drivers of this association.
CLINICAL NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Ana Clara Neville Armond Santos, Myrelle Louise Duarte de Souza, Adriane Moreira Machado, Camila Kummel Duarte
Summary: Diet composition has a significant impact on body composition. Adding olive oil to a calorie-restricted diet may be beneficial for weight loss, but its effect on body fat distribution remains unclear. This systematic review and meta-analysis aimed to investigate the impact of olive oil consumption on body fat distribution in adults.
Article
Pharmacology & Pharmacy
Samantha J. Snow, Andres R. Henriquez, Jenifer I. Fenton, Travis Goeden, Anna Fisher, Beena Vallanat, Michelle Angrish, Judy E. Richards, Mette C. Schladweiler, Wan-Yun Cheng, Charles E. Wood, Haiyan Tong, Urmila P. Kodavanti
Summary: This study found that diets enriched with coconut oil, fish oil, or olive oil can modify ozone-induced metabolic changes in a diet-specific manner. Different types of dietary oils have different impacts on metabolic responses, potentially leading to alterations in peripheral energy homeostasis.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Jing Guo, Nicole Schupf, Emily Cruz, Yaakov Stern, Richard P. Mayeux, Yian Gu
Summary: The study found an association between Mediterranean diet intake and activities of daily living in older adults. Higher Mediterranean diet scores were associated with a decreased risk of ADL disability.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Nutrition & Dietetics
Antonio Cutruzzola, Martina Parise, Rosarina Vallelunga, Francesco Lamanna, Agostino Gnasso, Concetta Irace
Summary: Post-prandial hyperglycemia may lead to early atherosclerosis development, with EVOO showing better control over it compared to butter. Adding EVOO to a high glycemic index meal improves vascular function in type 1 diabetes patients.
Article
Biochemistry & Molecular Biology
Beatriz Sanchez-Calvo, Adriana Cassina, Mauricio Mastrogiovanni, Mariela Santos, Emiliano Trias, Eric E. Kelley, Homero Rubbo, Andres Trostchansky
Summary: The consumption of extra virgin olive oil has been shown to reduce the development of non-alcoholic fatty liver disease (NAFLD), with nitro-fatty acids potentially playing a key role in this benefit. Supplementation with olive oil and nitrite can improve liver mitochondrial function in mice and reduce fat liver accumulation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Nutrition & Dietetics
Asra Fazlollahi, Kimia Motlagh Asghari, Cynthia Aslan, Maryam Noori, Seyed Aria Nejadghaderi, Mostafa Araj-Khodaei, Mark J. M. Sullman, Nahid Karamzad, Ali-Asghar Kolahi, Saeid Safiri
Summary: This study conducted a systematic review to examine the relationship between olive oil consumption and cognition. The review included eleven studies, which consistently found that olive oil consumption had a favorable effect on cognitive performance and was positively associated with cognitive health. However, further large-scale investigations are needed to strengthen this conclusion.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Thanh Truong Giang Ly, Jisoo Yun, Dong-Hyung Lee, Joo-Seop Chung, Sang-Mo Kwon
Summary: Active components in olive oil show promising results in various diseases affecting women's health, especially in breast cancer, ovarian cancer, postmenopausal osteoporosis, and other disorders. Scientists have focused on natural products and their derivatives for their good tolerability and effectiveness in disease prevention and treatment.
Article
Clinical Neurology
Roberto Latina, Giustino Varrassi, Ettore Di Biagio, Diana Giannarelli, Francesco Gravante, Antonella Paladini, Daniela D'Angelo, Laura Iacorossi, Cristina Martella, Rosaria Alvaro, Dhurata Ivziku, Nicola Veronese, Mario Barbagallo, Anna Marchetti, Paolo Notaro, Irene Terrenato, Gianfranco Tarsitani, Maria Grazia De Marinis
Summary: Opioids are effective in managing moderate or severe chronic pain. The use of invasive treatments and complementary therapy is associated with severe or moderate pain. The choice of a pain clinic is influenced by clinical parameters such as the nature of pain, multi-diagnosis, multiple sites of pain, treatments, and general practitioner.
Article
Biochemistry & Molecular Biology
Lydia Giannitrapani, Luigi Mirarchi, Simona Amodeo, Anna Licata, Maurizio Soresi, Francesco Cavaleri, Salvatore Casalicchio, Gregorio Ciulla, Maria Elena Ciuppa, Melchiorre Cervello, Mario Barbagallo, Nicola Veronese
Summary: The immune response to COVID-19 is important, but some patients experience persistent symptoms that lead to a global health and economic burden. This study investigates the potential role of IL-6 levels as a marker for long COVID. The analysis of 184 patients admitted to a hospital in Italy revealed that higher IL-6 levels were associated with a doubled risk of long COVID, mobility decline, and PTSD, indicating the significance of IL-6 in disease severity, unfavorable outcomes, and long COVID development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Marco Solmi, Trevor Thompson, Andres Estrade, Agorastos Agorastos, Joaquim Radua, Samuele Cortese, Elena Dragioti, Friedrich Leisch, Davy Vancampfort, Lau Caspar Thygesen, Harald Aschauer, Monika Schloegelhofer, Elena Aschauer, Andres Schneeberger, Christian G. Huber, Gregor Hasler, Philippe Conus, Kim Q. Do Cuenod, Roland von Kaenel, Gonzalo Arrondo, Paolo Fusar-Poli, Philip Gorwood, Pierre-Michel Llorca, Marie-Odile Krebs, Elisabetta Scanferla, Taishiro Kishimoto, Golam Rabbani, Karolina Skonieczna-Zydecka, Paolo Brambilla, Angela Favaro, Akihiro Takamiya, Leonardo Zoccante, Marco Colizzi, Julie Bourgin, Karol Kaminski, Maryam Moghadasin, Soraya Seedat, Evan Matthews, John Wells, Emilia Vassilopoulou, Ary Gadelha, Kuan-Pin Su, Jun Soo Kwon, Minah Kim, Tae Young Lee, Oleg Papsuev, Denisa Mankova, Andrea Boscutti, Cristiano Gerunda, Diego Saccon, Elena Righi, Francesco Monaco, Giovanni Croatto, Guido Cereda, Jacopo Demurtas, Natascia Brondino, Nicola Veronese, Paolo Enrico, Pierluigi Politi, Valentina Ciappolino, Andrea Pfennig, Andreas Bechdolf, Andreas Meyer-Lindenberg, Kai G. Kahl, Katharina Domschke, Michael Bauer, Nikolaos Koutsouleris, Sibylle Winter, Stefan Borgwardt, Istvan Bitter, Judit Balazs, Pal Czobor, Zsolt Unoka, Dimitris Mavridis, Konstantinos Tsamakis, Vasilios P. Bozikas, Chavit Tunvirachaisakul, Michael Maes, Teerayuth Rungnirundorn, Thitiporn Supasitthumrong, Ariful Haque, Andre R. Brunoni, Carlos Gustavo Costardi, Felipe Barreto Schuch, Guilherme Polanczyk, Jhoanne Merlyn Luiz, Lais Fonseca, Luana V. Aparicio, Samira S. Valvassori, Merete Nordentoft, Per Vendsborg, Sofie Have Hoffmann, Jihed Sehli, Norman Sartorius, Sabina Heuss, Daniel Guinart, Jane Hamilton, John Kane, Jose Rubio, Michael Sand, Ai Koyanagi, Aleix Solanes, Alvaro Andreu-Bernabeu, Antonia San Jose Caceres, Celso Arango, Covadonga M. Diaz-Caneja, Diego Hidalgo-Mazzei, Eduard Vieta, Javier Gonzalez-Penas, Lydia Fortea, Mara Parellada, Miquel A. Fullana, Norma Verdolini, Eva Andrlikova, Karolina Janku, Mark John Millan, Mihaela Honciuc, Anna Moniuszko-Malinowska, Igor Loniewski, Jerzy Samochowiec, Lukasz Kiszkiel, Maria Marlicz, Pawel Sowa, Wojciech Marlicz, Georgina Spies, Brendon Stubbs, Joseph Firth, Sarah Sullivan, Asli Enez Darcin, Hatice Aksu, Nesrin Dilbaz, Onur Noyan, Momoko Kitazawa, Shunya Kurokawa, Yuki Tazawa, Alejandro Anselmi, Cecilia Cracco, Ana Ines Machado, Natalia Estrade, Diego De Leo, Jackie Curtis, Michael Berk, Philip Ward, Scott Teasdale, Simon Rosenbaum, Wolfgang Marx, Adrian Vasile Horodnic, Liviu Oprea, Ovidiu Alexinschi, Petru Ifteni, Serban Turliuc, Tudor Ciuhodaru, Alexandra Bolos, Valentin Matei, Dorien H. Nieman, Iris Sommer, Jim van Os, Therese van Amelsvoort, Ching-Fang Sun, Ta-wei Guu, Can Jiao, Jieting Zhang, Jialin Fan, Liye Zou, Xin Yu, Xinli Chi, Philippe de Timary, Ruud van Winkel, Bernardo Ng, Edilberto Pena, Ramon Arellano, Raquel Roman, Thelma Sanchez, Larisa Movina, Pedro Morgado, Sofia Brissos, Oleg Aizberg, Anna Mosina, Damir Krinitski, James Mugisha, Dena Sadeghi-Bahmani, Farshad Sheybani, Masoud Sadeghi, Samira Hadi, Serge Brand, Antonia Errazuriz, Nicolas Crossley, Dragana Ignjatovic Ristic, Carlos Lopez-Jaramillo, Dimitris Efthymiou, Praveenlal Kuttichira, Roy Abraham Kallivayalil, Afzal Javed, Muhammad Iqbal Afridi, Bawo James, Omonefe Joy Seb-Akahomen, Jess Fiedorowicz, Andre F. Carvalho, Jeff Daskalakis, Lakshmi N. Yatham, Lin Yang, Tarek Okasha, Aicha Dahdouh, Bjoern Gerdle, Jari Tiihonen, Jae Il Shin, Jinhee Lee, Ahmed Mhalla, Lotfi Gaha, Takoua Brahim, Kuanysh Altynbekov, Nikolay Negay, Saltanat Nurmagambetova, Yasser Abu Jamei, Mark Weiser, Christoph U. Correll
Summary: The COH-FIT survey is a valid instrument to measure global mental health during the COVID-19 pandemic. The study confirmed the validity of COH-FIT items and the internal reliability of the co-primary outcome, the P-score. The survey has been translated into 30 languages and measures various mental health symptoms and factors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Editorial Material
Endocrinology & Metabolism
Nicola Veronese, Shaun Sabico
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Francesco Pollicino, Nicola Veronese, Ligia J. Dominguez, Mario Barbagallo
Summary: Mitochondria play a critical role in various energy processes and are important in the physiological response to stress, aging, and disease. The Mediterranean diet has been found to affect mitochondrial function, reducing the risk of negative health outcomes. Components of the Mediterranean diet, such as polyphenols, can limit free radicals and have anti-inflammatory effects, improving mitochondrial function. It is necessary to conduct further studies in humans to confirm these findings.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Geriatrics & Gerontology
Ligia J. Dominguez, Carolina Donat-Vargas, Carmen Sayon-Orea, Maria Barberia-Latasa, Nicola Veronese, Jimena Rey-Garcia, Fernando Rodriguez-Artalejo, Pilar Guallar-Castillon, Miguel Angel Martinez-Gonzalez, Mario Barbagallo
Summary: Frailty is a geriatric syndrome with increasing frequency and dire consequences due to population aging. Nutritional factors, particularly the Mediterranean diet, play a crucial role in its pathogenesis. A systematic review and meta-analysis confirmed a robust association between higher adherence to the Mediterranean diet and reduced incident frailty. Promoting the Mediterranean diet as a high-quality dietary pattern adapted to different regions offers an opportunity to counteract the spread of unhealthy eating and lifestyle models and reduce frailty incidence.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Nutrition & Dietetics
Maria del Carmen Macias Ruiz, Lorena Cuenca Bermejo, Nicola Veronese, Emiliano Fernandez Villalba, Ana Maria Gonzalez Cuello, Karolina Kublickiene, Valeria Raparelli, Colleen M. Norris, Alexandra Kautzky-Willer, Louise Pilote, Mario Barbagallo, Ligia Dominguez, Maria Trinidad Herrero
Summary: This article reviews the role of magnesium in health and illness, with emphasis on the elderly population with chronic kidney disease (CKD) and potential sex differences. It is found that magnesium can be used as an adjunctive treatment for CKD patients to improve glomerular filtration, but further research and characterization are needed for its clinical applications. Therefore, well-designed prospective clinical trials are needed to establish guidelines for magnesium supplementation, considering age and sex.
Article
Nutrition & Dietetics
Sara De Nucci, Roberta Rinaldi, Martina Di Chito, Rossella Donghia, Vito Giannuzzi, Endrit Shahini, Raffaele Cozzolongo, Pasqua Letizia Pesole, Sergio Coletta, Giovanni De Pergola, Gianluigi Giannelli
Summary: The gold standard treatment for NAFLD is weight loss and lifestyle interventions, which involve dietary changes such as reducing sugar and saturated fat intake and increasing fiber consumption. This study aims to evaluate the effects of a diet enriched with green leafy vegetables and moderate carbohydrate restriction on NAFLD patients over a three month period.
Correction
Clinical Neurology
Roberto Latina, Giustino Varrassi, Ettore Di Biagio, Diana Giannarelli, Francesco Gravante, Antonella Paladini, Daniela D'Angelo, Laura Iacorossi, Cristina Martella, Rosaria Alvaro, Dhurata Ivziku, Nicola Veronese, Mario Barbagallo, Anna Marchetti, Paolo Notaro, Irene Terrenato, Gianfranco Tarsitani, Maria Grazia De Marinis
Article
Nutrition & Dietetics
Nicola Veronese, Ai Koyanagi, Pinar Soysal, Francesco Bolzetta, Ligia J. J. Dominguez, Mario Barbagallo, Shaun Sabico, Nasser M. M. Al-Daghri, Lee Smith
Summary: This study found a significant association between DAO and the risk of falls in older adults, while dynapenia alone was not related to falls. This is important for fall prevention and control, and therefore deserves attention.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Caterina Bonfiglio, Francesco Cuccaro, Angelo Campanella, Natalia Rosso, Rossella Tatoli, Gianluigi Giannelli, Rossella Donghia
Summary: This study demonstrates the protective effect of olive oil consumption against all causes of mortality, especially in individuals with non-alcoholic fatty liver disease. The protective power is greater for consumption over 40g/day in both the overall cohort and the sub-cohorts with and without NAFLD.
Article
Nutrition & Dietetics
Rossella Donghia, Pasqua Letizia Pesole, Antonino Castellaneta, Sergio Coletta, Francesco Squeo, Caterina Bonfiglio, Giovanni De Pergola, Roberta Rinaldi, Sara De Nucci, Gianluigi Giannelli, Alfredo Di Leo, Rossella Tatoli
Summary: This study aimed to investigate the association between food intake and liver disease, and evaluate the differences in blood parameters among different age groups and steatosic condition. The results showed significant variations in both dietary habits and blood parameters between adult and elderly groups.
Article
Geriatrics & Gerontology
Nicola Veronese, Ai Koyanagi, Pinar Soysal, Vitalba Sapienza, Francesco Saverio Ragusa, Francesco Bolzetta, Ligia J. Dominguez, Mario Barbagallo, Lee Smith
Summary: This study aimed to investigate the association between dynapenic abdominal obesity (DAO) at baseline and the development of multimorbidity over a 10-year follow-up period. The results showed that both abdominal obesity and DAO significantly increased the risk of multimorbidity. DAO was also associated with a higher risk of arthritis and diabetes.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Francesco Saverio Ragusa, Luisa Solimando, Caterina Mandala, Roberta Masnata, Gregorio Ciulla, Stefano Ciriminna, Francesco La Blasca, Pasquale Mansueto, Nicola Veronese, Mario Barbagallo
Summary: The study found a positive association between higher multidimensional prognostic index (MPI) values, indicating frailty, and the prevalence of infectious diseases, including multidrug-resistant pathogens, resulting in increased antibiotic costs.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Review
Rheumatology
Sara Tenti, Olivier Bruyere, Sara Cheleschi, Jean-Yves Reginster, Nicola Veronese, Antonella Fioravanti
Summary: Osteoarthritis (OA) is a prevalent condition worldwide, causing pain, disability, reduced social activities, and impaired quality of life. The current therapeutic options are limited and focus mainly on managing symptoms, lacking disease-modifying drugs. Efforts have been made to find potential therapeutic targets for OA, repurposing existing drugs used for inflammatory rheumatic diseases. Unfortunately, the use of conventional and biologic drugs for hand osteoarthritis (HOA) has not been successful, highlighting the need for research on HOA molecular mechanisms and personalized treatment options.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)