Article
Biochemistry & Molecular Biology
Shiling Feng, Chunyan Zhang, Tao Chen, Lijun Zhou, Yan Huang, Ming Yuan, Tian Li, Chunbang Ding
Summary: The study found that OLE significantly prolongs the lifespan of Caenorhabditis elegans and increases their resistance to lethal heat shock and oxidative stress. OLE regulates stress resistance and lifespan extension in nematodes through the activation of the IIS and SKN-1/Nrf2 signaling pathways.
Article
Food Science & Technology
Mingfang Tao, Rong Li, Tingting Xu, Zhuo Zhang, Dan Zheng, Zhenzhen Xia, Ting Wu, Siyi Pan, Xiaoyun Xu
Summary: This study found that vitexin and isovitexin can activate the SKN-1/Nrf2 signaling pathway and extend the lifespan of Caenorhabditis elegans. They achieve this by upregulating antioxidant gene and protein expressions, reducing ROS accumulation, and increasing SKN-1 accumulation in the nucleus.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Article
Food Science & Technology
Mingfang Tao, Rong Li, Tingting Xu, Zhuo Zhang, Dan Zheng, Zhenzhen Xia, Ting Wu, Siyi Pan, Xiaoyun Xu
Summary: This study found that vitexin and isovitexin can extend lifespan and promote healthspan in Caenorhabditis elegans by activating the SKN-1/Nrf2 signaling pathway. They can also clear ROS during stressful conditions and retard cellular senescence by directly binding to Keap1. These findings provide new insights into apigenin C-glycosides as potential candidates for preventing aging and oxidative-related diseases.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Article
Engineering, Environmental
Yufang Gao, Ting Yu, Yalan Wu, Xuedi Huang, Jialuo Teng, Nan Zhao, Xiaodong Zheng, Fujie Yan
Summary: This study investigated the mechanisms of Bacillus coagulans (Weizmannia coagulans) XY2 against Cu-induced oxidative stress using a dual model. Cu disrupted the microbial community structure, while XY2 intervention reversed this trend and alleviated Cu-induced metabolic disturbances. In addition, XY2 mitigated the oxidative damage caused by Cu exposure through regulating DAF-16/FoxO and SKN-1/Nrf2 pathways and intestinal flora. This research provides a theoretical basis for formulating future strategies of probiotics against heavy metal contamination.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Siqi Jiang, Na Deng, Bisheng Zheng, Tong Li, Rui Hai Liu
Summary: Rhodiola extract was found to significantly extend the lifespan of C. elegans and enhance its stress resistance by regulating gene expression and promoting protein translocation.
Article
Plant Sciences
Chun-Han Chang, Chia-Cheng Wei, Chi-Tang Ho, Vivian Hsiu-Chuan Liao
Summary: The study showed that Glu-SeMet has neuroprotective effects in a C. elegans PD model, potentially through the SKN-1/Nrf2 and TRXR-1 pathways.
Article
Integrative & Complementary Medicine
Sara Thabit, Heba Handoussa, Nesrine S. Elsayed, Hans-Georg Breitinger, Ulrike Breitinger, Michael Wink
Summary: This study investigated the neuroprotective activities of a hydroalcoholic extract from Styphnolobium japonicum fruits. The extract activated the SKN-1/Nrf2 pathway, resulting in resistance to oxidative stress, and showed potential pharmacological activities for the treatment of Huntington's, Parkinson's, and Alzheimer's diseases.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Endocrinology & Metabolism
Hong-Duc Phan, Tin Tin Manh Nguyen, Sujin Lee, Munjun Seo, Yong Jin An, Arvie Camille V. de Guzman
Summary: By using metabolomic profiling and gene expression analysis, we found that SKN-1/Nrf2 plays a role in worm lifespan modulation through cytoprotective mechanisms, including cellular redox reactions and xenobiotic detoxification system. skn-1-knockdown worms exhibited distinctive metabolic profiles compared to wild-type worms, with an increase in phosphocholine and AMP/ATP ratio, and a decrease in transsulfuration metabolites, NADPH/NADP(+) ratio, and total glutathione. Furthermore, the expression of genes involved in GSHt and NADPH synthesis as well as in the phase II detoxification system was downregulated in skn-1-RNAi worms.
Article
Chemistry, Medicinal
Prapaporn Jattujan, Sirin Srisirirung, Warisra Watcharaporn, Kawita Chumphoochai, Pichnaree Kraokaew, Tanatcha Sanguanphun, Prachayaporn Prasertsuksri, Salinthip Thongdechsri, Prasert Sobhon, Krai Meemon
Summary: The present study investigated the anti-aging activity of purified compounds from the sea cucumber, Holothuria scabra, in a Caenorhabditis elegans model. It was found that 2-BTHF and palmitic acid could extend the lifespan of the worms and enhance their resistance to oxidative and thermal stress. The study also revealed that these compounds exerted their actions through the DAF-16/FOXO insulin/IGF and SKN-1/NRF2 signaling pathways.
Article
Biochemistry & Molecular Biology
Mengyao Liu, Nana Li, Shan Shan, Yudong Shi, Yuanbin Zhu, Weihong Lu
Summary: This study revealed the significant role of Acanthopanax senticosus polysaccharide (ASPS) in regulating immune damage caused by radiation. The results showed that ASPS can directly elevate the immune response of nematodes, effectively enhancing their resistance against pathogens in radiation-damaged conditions. Additionally, ASPS also alleviated the stress status of damaged nematodes by regulating oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria D. Navarro-Hortal, Jose M. Romero-Marquez, Pedro Munoz-Ollero, Victoria Jimenez-Trigo, Adelaida Esteban-Munoz, Kilian Tutusaus, Francesca Giampieri, Maurizio Battino, Cristina Sanchez-Gonzalez, Lorenzo Rivas-Garcia, Juan Llopis, Tamara Y. Forbes-Hernandez, Jose L. Quiles
Summary: Alzheimer's is a chronic degenerative disease of the central nervous system, characterized by oxidative stress and the aggregation of beta-amyloid peptide and hyperphosphorylated Tau protein. Manuka Honey may have potential in improving symptoms, but there is currently no scientific evidence supporting its effectiveness.
Article
Geriatrics & Gerontology
Ferbian Milas Siswanto, Rika Sakuma, Ami Oguro, Susumu Imaoka
Summary: Chlorogenic acid (CGA), the most abundant polyphenol in coffee, exhibits antioxidant activity by activating the Nrf2 pathway. This study revealed that CGA inhibits FOXO3 nuclear accumulation and decreases the expression of DDB1, leading to increased Nrf2 activity. The study also found that CGA extends the lifespan of C. elegans through this pathway.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Huimin Liu, Ying Wang, Weiping Zhang, Weichao Sun, Xiaoxue Ji, Shouan Zhang, Kang Qiao
Summary: This study demonstrated that lentinan from Lentinus edodes could effectively increase the lifespan and enhance oxidative stress resistance in Caenorhabditis elegans through the activation of DAF-16 and SKN-1.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Maria Alejandra Guerrero-Rubio, Samanta Hernandez-Garcia, Francisco Garcia-Carmona, Fernando Gandia-Herrero
Summary: Flavonoids, potential nutraceutical compounds found in dairy food, are considered health-promoting compounds with promising therapeutic effects on neurological, inflammatory diseases, diabetes, and cancer. In Caenorhabditis elegans, chrysin, 6-hydroxyflavone, and baicalein were found to significantly extend lifespan, with effects mediated by different signaling pathways. Microarray analysis showed that baicalein downregulates important age-related genes such as mTOR and PARP.
Article
Plant Sciences
Jianfeng Wang, Xinhua Liu, Shuqin Hang, Chunxin Cao, Yucheng He, Xiaoming Sun, Rongquan Zheng, Jianfeng Yuan
Summary: The study shows that onion vinegar (OV) has superior content of total flavonoids and polyphenols, high radical scavenging activity, and the ability to enhance antioxidant enzyme activities in C. elegans. OV can alleviate intracellular oxidative stress, enhance the resistance of C. elegans against oxidative stress, and increase its lifespan by activating the SKN-1 signaling pathway.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Medicine, Research & Experimental
Pedro Rojas-Morales, Juan Carlos Leon-Contreras, Monica Sanchez-Tapia, Alejandro Silva-Palacios, Agustina Cano-Martinez, Susana Gonzalez-Reyes, Angelica Sarai Jimenez-Osorio, Rogelio Hernandez-Pando, Horacio Osorio-Alonso, Laura Gabriela Sanchez-Lozada, Armando R. Tovar, Jose Pedraza-Chaverri, Edilia Tapia
Summary: This study found that short-term ketogenic diet can increase tolerance to experimental kidney ischemia, reduce kidney injury and inflammation, and enhance antioxidant defenses. This finding opens up possibilities for future therapeutic strategies.
Article
Neurosciences
Iris N. Serratos, Elizabeth Hernandez-Perez, Carolina Campos, Michael Aschner, Abel Santamaria
Summary: The aggregation of alpha-synuclein plays a critical role in the development of Parkinson's disease and other synucleinopathies. Changes in protein conformation due to mutations and post-translational modifications lead to the abnormal aggregation of alpha-synuclein, which contributes to the progression of these diseases.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Arana-Hidalgo Dana, Silva-Palacios Alejandro
Summary: SFN acts as a versatile nutraceutical agent by regulating cellular stress responses and modulating ER stress through the Nrf2-mediated antioxidant pathway, thus maintaining cellular homeostasis balance.
Article
Pharmacology & Pharmacy
Fernando Lazcano-Perez, Edgar Rangel-Lopez, Benjamin Robles-Banuelos, Adrian Marcelo Franco-Vasquez, Alejandro Garcia-Arredondo, Juan Carlos Navarro-Garcia, Ariana Zavala-Moreno, Saul Gomez-Manzo, Abel Santamaria, Roberto Arreguin-Espinosa
Summary: Snake venom contains enzymes with important roles in venom action and symptoms. In this study, we characterized a fraction of venom from the Mexican rattlesnake Crotalus molossus nigrescens and found that it exhibited phospholipase A2 activity. This fraction showed cytotoxic effects on brain tumor cells and had low neurotoxic effects on primary neuronal cultures. These findings suggest its potential as an anticancer agent in oncology medicine.
Review
Biochemistry & Molecular Biology
Benjamin Robles-Banuelos, Lorena Maria Duran-Riveroll, Edgar Rangel-Lopez, Hugo Isidro Perez-Lopez, Leticia Gonzalez-Maya
Summary: Marine cyanobacteria are a remarkable source of biologically active molecules. Their diverse chemical compounds have demonstrated important bioactivities, including anticancer properties, making them a promising area of research for new drugs.
Article
Chemistry, Medicinal
Alejandro Silva-Palacios, Miguel Arroyo-Campuzano, Mirthala Flores-Garcia, Mariana Patlan, Adrian Hernandez-Diazcouder, Diego Alcantara, Ixchel Ramirez-Camacho, Dana Arana-Hidalgo, Elizabeth Soria-Castro, Fausto Sanchez, Hector Gonzalez-Pacheco, Cecilia Zazueta
Summary: Extracellular vesicles, specifically exosomes, play a crucial role in cell communication. This study investigates the impact of citicoline on modifying relevant proteins and miRNAs in exosomes from ST-segment elevation myocardial infarction (STEMI) patients. The results demonstrate that citicoline treatment alters the expression of specific miRNAs related to cardioprotection in exosomes.
Review
Geriatrics & Gerontology
Silva-Palacios Alejandro
Summary: Longitudinal studies are necessary to study aging, but they have limitations. In vitro studies provide valuable information on understanding the aging process. The D-galactose-induced premature aging model mimics many cellular processes seen in natural aging, but the role of endoplasmic reticulum stress and unfolded protein response is not fully understood.
EXPERIMENTAL GERONTOLOGY
(2022)
Review
Neurosciences
Hipolito A. Ruiz-Contreras, Abel Santamaria, Monica G. Arellano-Mendoza, Laura Sanchez-Chapul, Benjamin Robles-Banuelos, Edgar Rangel-Lopez
Summary: The Endocannabinoid System plays a crucial role in the Central Nervous System, particularly in neuroprotection and nerve cell proliferation. Cannabinoid receptors CB1R and CB2R regulate the proliferation of neurons and glial cells. Endocannabinoids have significant effects on nerve cell proliferation, but specific mechanisms are not fully understood.
NEUROTOXICITY RESEARCH
(2022)
Article
Cell Biology
Francisco Correa, Cristina Enriquez-Cortina, Alejandro Silva-Palacios, Nadia Roman-Anguiano, Aurora Gil-Hernandez, Marcos Ostolga-Chavarria, Elizabeth Soria-Castro, Sharik Hernandez-Rizo, Paola de los Heros, Maria Chavez-Canales, Cecilia Zazueta
Summary: This study explores the role of the actin-cytoskeleton network in caveolae-mitochondria communication during postconditioning. The results show that disruption of the actin-cytoskeleton network negatively impacts cardiac tissue morphology, reduces caveolae formation, impairs cardiac function, and inhibits mitochondrial respiration. These findings highlight the importance of actin-cytoskeleton in regulating caveolae signaling to mitochondria and its role in cardioprotection against reperfusion injury.
Article
Biochemistry & Molecular Biology
Fernando E. E. Garcia-Arroyo, Guillermo Gonzaga-Sanchez, Alejandro Silva-Palacios, Francisco Javier Roldan, Maria L. Loredo-Mendoza, Yamnia Quetzal Alvarez-Alvarez, Jesus A. A. de los Santos Coyotl, Kevin A. Velez A. Orozco, Edilia Tapia, Horacio Osorio-Alonso, Abraham S. S. Arellano-Buendia, Jose L. Sanchez-Gloria, Miguel A. A. Lanaspa, Richard J. J. Johnson, Laura Gabriela Sanchez-Lozada
Summary: There is a growing body of evidence suggesting that fructose, either ingested or produced in the body, may play a role in metabolic syndrome. This study investigated the effects of a high fat/sugar diet on cardiac health and fructose metabolism in rats, and found that increased fructose content and metabolism in cardiac tissue were associated with cardiac hypertrophy, hypoxia, oxidative stress, and increased activity of fructokinase. These effects were reversed by a fructokinase inhibitor, suggesting that blocking fructokinase could have cardiac benefits in metabolic syndrome.
Review
Geriatrics & Gerontology
Mario Nieto, Mina Konisgberg, Alejandro Silva-Palacios
Summary: Cellular senescence is associated with the development and progression of multiple age-related diseases, and the accumulation of senescent cells in the heart contributes to age-related pathologies. The use of senolytics has shown promise in eliminating these cells and providing potential therapies for cardiovascular disease.
Article
Biochemistry & Molecular Biology
Alejandro Silva-Palacios, Dana Arana-Hidalgo, Zaira Colin-Val, Vicente Castrejon-Tellez, Elizabeth Soria-Castro, Jose Pedraza-Chaverri, Rebeca Lopez-Marure, Cecilia Zazueta
Summary: Mitochondria-endoplasmic reticulum (ER) communication is dependent on platforms formed at the ER membrane with the mitochondrial outer membrane contact sites (MERCs). Alterations in MERCs greatly impact cellular metabolism, making the preservation of productive mitochondrial-ER communication crucial for cellular homeostasis. This study investigates the effect of sulforaphane (SFN), which is known to have potential therapeutic effects, on MERCs under normal culture conditions.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Correction
Biochemistry & Molecular Biology
Alejandro Silva-Palacios, Ana L. Colin-Gonzalez, Stefanie P. Lopez-Cervantes, Cecilia Zazueta, Armando Luna-Lopez, Abel Santamaria, Mina Konigsberg
Article
Biochemistry & Molecular Biology
Belen Cuevas-Lopez, Edgar Ignacio Romero-Ramirez, Fernando E. Garcia-Arroyo, Edilia Tapia, Juan Carlos Leon-Contreras, Alejandro Silva-Palacios, Francisco-Javier Roldan, Omar Noel Medina Campos, Luz Hernandez-Esquivel, Alvaro Marin-Hernandez, Jose Guillermo Gonzaga-Sanchez, Rogelio Hernandez-Pando, Jose Pedraza-Chaverri, Laura Gabriela Sanchez-Lozada, Omar Emiliano Aparicio-Trejo
Summary: The incidence of kidney disease is increasing globally, and acute kidney injury (AKI) can contribute to the development of cardio-renal syndrome (CRS) type 3. However, the mechanism behind CRS development is not fully understood. This study aimed to investigate the molecular mechanisms associated with cardiac mitochondrial impairment and its role in CRS development. The findings suggest that mitochondrial bioenergetics impairment plays a crucial role in heart damage, and the preservation of heart mitochondrial function during AKI could be a valuable strategy to prevent CRS type 3.