Article
Neurosciences
Marco Venniro, Rosa A. M. Marino, Jonathan J. Chow, Daniele Caprioli, David H. Epstein, Leslie A. Ramsey, Yavin Shaham
Summary: This article discusses the role of social factors in addiction research using animal models. Social isolation promotes drug use and relapse, while social connections provide protection. The article summarizes the effects of different experimental procedures on opioids and psychostimulants, and suggests future research directions in the addiction field.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Ida Fredriksson, Pei-Jung Tsai, Aniruddha Shekara, Ying Duan, Sarah Applebey, Hanbing Lu, Jennifer M. Bossert, Yavin Shaham, Yihong Yang
Summary: Through experiments, it was found that both opioid self-administration and voluntary abstinence can induce changes in functional connectivity between the orbitofrontal cortex and dorsal striatum, as well as related circuits in rats. These connectivity changes can predict individual differences in the incubation of opioid craving.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Psychology, Clinical
R. Kathryn McHugh, Catherine D. Trinh, Margaret L. Griffin, Roger D. Weiss
Summary: The study extended prior psychometric analyses of the Craving Scale to a large sample of adults seeking treatment for substance use disorders (N = 1,283). Results indicated that the Craving Scale has good readability, strong internal consistency reliability, and adequate concurrent and discriminant validity. Analyses also showed similar results for alcohol and opioid craving, as well as for men and women, supporting measure invariance across these key groups.
ADDICTIVE BEHAVIORS
(2021)
Article
Neurosciences
Aria Gillespie, Hannah L. Mayberry, Mathieu E. Wimmer, Stephanie E. Sillivan
Summary: This study demonstrated that 30 days of forced abstinence results in increased morphine seeking in a rat model of morphine self-administration. The expression of miRNAs in the nucleus accumbens is influenced by the timing of abstinence and whether animals undergo a relapse test, which may be related to drug history.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Anesthesiology
Leah Frimerman, Maria Verner, Amanda Sirois, Katherine Scott, Alice Bruneau, Jordi Perez, Yoram Shir, Marc O. Martel
Summary: This study examined the impact of hedonic and calming effects of opioids on misuse among patients with chronic pain. The results indicated that these effects were associated with heightened opioid craving and were moderated by pain intensity, catastrophizing, and negative affect.
Article
Substance Abuse
Jennifer D. Ellis, Kelly E. Dunn, Patrick Finan, Andrew S. Huhn, Orrin D. Ware, J. Gregory Hobelmann
Summary: This study utilized a large, multi-site database to investigate the impact of chronic pain and gender on the severity of opioid withdrawal. The findings suggest that women and individuals with chronic pain experience more severe symptoms of opioid withdrawal, requiring earlier engagement in treatment and potentially a more intensive approach to mitigate withdrawal symptoms.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Substance Abuse
Cecilia L. Bergeria, Justin C. Strickland, Andrew S. Huhn, Eric C. Strain, Kelly E. Dunn
Summary: This mixed-methods study identified eight different dimensions of opioid craving based on qualitative responses collected via Amazon Mechanical Turk. The study found that opioid craving is a multidimensional construct with no single unifying dimension. Participants with more severe drug use characteristics were more likely to describe craving as Interfering Thoughts. Respondents tended to prefer Visual Analog Scale response formats over Likert scales when describing opioid craving.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Review
Substance Abuse
Kasey G. Creswell, Michael A. Sayette
Summary: In the past two decades, research interest in alcohol and other drug craving has grown, with evidence showing a significant link between craving and drug use and relapse. Studies have mainly focused on craving as a clinical phenomenon, emphasizing the need for a more comprehensive understanding beyond self-reported cravings. Due to differences between alcohol and tobacco cravings, adopting ideas and methods from smoking research could advance the conceptual understanding of alcohol craving.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Psychology, Biological
Jenni B. Teeters, Jennifer L. Jones, Amber M. Jarnecke, Sudie E. Back
Summary: This study investigated the role of sleep in individuals with OUD, finding that sleep quality may influence the relationship between craving and stress. Sleep impairment could be an important target in long-term treatment plans for patients with OUD.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Substance Abuse
Anna Parisi, Hannah Louise Landicho, Justin Hudak, Siri Leknes, Brett Froeliger, Eric L. Garland
Summary: Emotional distress and pain catastrophizing were found to predict cue-elicited craving and autonomic cue-reactivity among chronic pain patients receiving long-term opioid therapy. Pain severity did not have predictive power in this context. Furthermore, misuse status moderated the relationship between distress and self-reported craving.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Substance Abuse
Alice Bruneau, Leah Frimerman, Maria Verner, Amanda Sirois, Catherine Fournier, Katherine Scott, Jordi Perez, Yoram Shir, Marc O. Martel
Summary: This study examined the day-to-day association between opioid withdrawal symptoms and opioid craving among chronic pain patients, finding that elevations in withdrawal symptoms were associated with heightened craving. The results of a multilevel mediation analysis showed that this association was mainly mediated by patients' daily levels of negative affect and catastrophizing.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Engineering, Electrical & Electronic
Giovanni Saggio, Alexandre Calado, Vito Errico, Bor-Shing Lin, I-Jung Lee
Summary: Sensory gloves are capable of measuring finger movements and are useful in multiple applications. This study proposes a testing procedure for assessing the measurements under dynamic conditions using two types of sensory gloves. The results show the feasibility of measuring dynamic finger movements and the differences in measurement repeatability and reliability between the two types of gloves.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Environmental Sciences
Xiaoyue Huang, Minghui Chang, Lei Han, Jie Li, Shi-Wei Li, Hong-Bo Li
Summary: This study assessed the bioaccessibility of lead (Pb) in 4 commonly used standard reference materials (SRMs). The results showed that the measurements of Pb bioaccessibility were repeatable and reproducible within and between laboratories. The use of these SRMs as quality control samples is reliable for Pb bioaccessibility analysis.
Article
Substance Abuse
Kyler S. Knapp, Scott C. Bunce, Timothy R. Brick, Erin Deneke, H. Harrington Cleveland
Summary: This study explored the daily relationships between craving, negative affect, and positive and negative social exchanges in residential treatment for opioid use disorders. Results showed that negative social exchanges were less frequent than positive social exchanges during treatment, and both negative affect and negative social exchanges were uniquely related to craving on a daily basis. Positive social exchanges also played a role in reducing the coupling between negative affect and craving.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2021)
Article
Multidisciplinary Sciences
Dan Liang, Aleksei Mikhalchenko, Hong Ma, Nuria Marti Gutierrez, Tailai Chen, Yeonmi Lee, Sang-Wook Park, Rebecca Tippner-Hedges, Amy Koski, Hayley Darby, Ying Li, Crystal Van Dyken, Han Zhao, Keliang Wu, Jingye Zhang, Zhenzhen Hou, Seongjun So, Jongsuk Han, Jumi Park, Chong-Jai Kim, Kai Zong, Jianhui Gong, Yilin Yuan, Ying Gu, Yue Shen, Susan B. Olson, Hui Yang, David Battaglia, Thomas O'Leary, Sacha A. Krieg, David M. Lee, Diana H. Wu, P. Barton Duell, Sanjiv Kaul, Jin-Soo Kim, Stephen B. Heitner, Eunju Kang, Zi-Jiang Chen, Paula Amato, Shoukhrat Mitalipov
Summary: The range of DNA repair in response to double-strand breaks induced in human preimplantation embryos is uncertain due to the complexity of analyzing single- or few-cell samples. Whole genome amplification, which is necessary for sequencing such minute DNA input, can introduce artifacts that restrict genotyping accuracy. This study shows that allelic dropouts occur in over 25% of pre-existing heterozygous loci in control single blastomere samples after whole genome amplification. To overcome these limitations, the authors validate gene editing seen in human embryos by studying embryonic stem cells.
NATURE COMMUNICATIONS
(2023)