FTO: An Emerging Molecular Player in Neuropsychiatric Diseases

A myriad of chemical modifications of DNA and histones involved in the epigenetic regulation of neural gene expression have been documented and studied in detail since many years. However, more recently, modifications in RNA and their implications for neural gene functions have been progressively investigated. Of these, the most widely studied is the N-6-methyladenosine (m(6)A) modification. The discovery of the first m(6)A demethylase, known as the fat, mass and obesity (FTO) associated protein, has further fortified the field of epitranscriptomic regulatory mechanisms, owing to FTO's involvement in several biological processes including brain development and function. Concomitantly, multiple lines of evidence have associated FTO with neuropsychiatric disorders. In this review, we discuss how FTO can exert its effect by acting not only on m(6)A but also on O, N-6 -dimethyladenosine (m(6)A m ) in different types of RNA and potentially influence the development of some major neuropsychiatric diseases. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.