Blocking CRH receptors in adults mitigates age-related memory impairments provoked by early-life adversity

Early Life Stress Delays Sexual Maturation in Female Mice

(2019) Gabriela Manzano Nieves et al.   Frontiers in Molecular Neuroscience

Early-life adversity and neurological disease: age-old questions and novel answers

(2019) Annabel K. Short et al.   Nature Reviews Neurology

Cortical Thinning and Neuropsychiatric Outcomes in Children Exposed to Prenatal Adversity: A Role for Placental CRH?

(2018) Curt A. Sandman et al.   AMERICAN JOURNAL OF PSYCHIATRY

Anhedonia Following Early-Life Adversity Involves Aberrant Interaction of Reward and Anxiety Circuits and Is Reversed by Partial Silencing of Amygdala Corticotropin-Releasing Hormone Gene

(2018) Jessica L. Bolton et al.   BIOLOGICAL PSYCHIATRY

The effects of early life stress on reward processing

(2018) Andrew M. Novick et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Early-life stress induces cognitive disorder in middle-aged mice

(2018) Hiroyuki Yajima et al.   NEUROBIOLOGY OF AGING

Hippocampal corticotropin-releasing hormone neurons support recognition memory and modulate hippocampal excitability

(2018) Andrew Hooper et al.   PLoS One

Early child adversity and psychopathology in adulthood: HPA axis and cognitive dysregulations as potential mechanisms

(2018) Catherine Raymond et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Morphological and functional changes in the preweaning basolateral amygdala induced by early chronic stress associate with anxiety and fear behavior in adult male, but not female rats

(2018) Angela Guadagno et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Hyper-diversity of CRH interneurons in mouse hippocampus

(2018) Benjamin G. Gunn et al.   Brain Structure & Function

NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience

(2017) A Singh-Taylor et al.   MOLECULAR PSYCHIATRY

Abnormal dendritic maturation of developing cortical neurons exposed to corticotropin releasing hormone (CRH): Insights into effects of prenatal adversity?

(2017) Megan M. Curran et al.   PLoS One

Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential

(2017) Claire-Dominique Walker et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

MRI uncovers disrupted hippocampal microstructure that underlies memory impairments after early-life adversity

(2016) Jenny Molet et al.   HIPPOCAMPUS

Early life stress accelerates behavioral and neural maturation of the hippocampus in male mice

(2016) K.G. Bath et al.   HORMONES AND BEHAVIOR

Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses

(2016) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

The effects of childhood maltreatment on brain structure, function and connectivity

(2016) Martin H. Teicher et al.   NATURE REVIEWS NEUROSCIENCE

Developmental changes in plasticity, synaptic, glia and connectivity protein levels in rat dorsal hippocampus

(2016) Alessio Travaglia et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Fragmentation and high entropy of neonatal experience predict adolescent emotional outcome

(2016) J Molet et al.   Translational Psychiatry

Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone

(2015) Andrew Hooper et al.   HIPPOCAMPUS

Epigenetic and transgenerational reprogramming of brain development

(2015) Tracy L. Bale   NATURE REVIEWS NEUROSCIENCE

Duration of early adversity and structural brain development in post-institutionalized adolescents

(2015) Amanda S. Hodel et al.   NEUROIMAGE

Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions

(2015) Torsten Klengel et al.   NEURON

Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks

(2015) Yuncai Chen et al.   NEUROPSYCHOPHARMACOLOGY

Structural Components of Synaptic Plasticity and Memory Consolidation

(2015) Craig H. Bailey et al.   Cold Spring Harbor Perspectives in Biology

Naturalistic rodent models of chronic early-life stress

(2014) Jenny Molet et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Chronic early life stress alters developmental and adult neurogenesis and impairs cognitive function in mice

(2014) Eva F.G. Naninck et al.   HIPPOCAMPUS

The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

(2014) Shawn McClelland et al.   eLife

Early life stress and later health outcomes-findings from the Helsinki Birth Cohort Study

(2013) Mia Eriksson et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

NMDA Receptor Activation and Calpain Contribute to Disruption of Dendritic Spines by the Stress Neuropeptide CRH

(2013) Adrienne L. Andres et al.   JOURNAL OF NEUROSCIENCE

Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss

(2013) Xiao-Dong Wang et al.   NATURE NEUROSCIENCE

Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1

(2012) Xiao-Dong Wang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Effects of Early-Life Abuse Differ across Development: Infant Social Behavior Deficits Are Followed by Adolescent Depressive-Like Behaviors Mediated by the Amygdala

(2012) C. Raineki et al.   JOURNAL OF NEUROSCIENCE

Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling

(2012) Y Chen et al.   MOLECULAR PSYCHIATRY

Sculpting the hippocampus from within: stress, spines, and CRH

(2012) Pamela M. Maras et al.   TRENDS IN NEUROSCIENCES

Associations between parenting behavior and anxiety in a rodent model and a clinical sample: relationship to peripheral BDNF levels

(2012) R Dalle Molle et al.   Translational Psychiatry

71: Magnetic resonance imaging (MRI) shows long term changes in brain structure in preterm infants exposed to chorioamnionitis

(2011) Tamera Hatfield et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling

(2011) Xiao-Dong Wang et al.   NEUROBIOLOGY OF DISEASE

Hippocampal Dysfunction and Cognitive Impairments Provoked by Chronic Early-Life Stress Involve Excessive Activation of CRH Receptors

(2010) A. S. Ivy et al.   JOURNAL OF NEUROSCIENCE

Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons

(2009) Deborah N. Alfarez et al.   HIPPOCAMPUS

Effects of stress throughout the lifespan on the brain, behaviour and cognition

(2009) Sonia J. Lupien et al.   NATURE REVIEWS NEUROSCIENCE

The neuro-symphony of stress

(2009) Marian Joëls et al.   NATURE REVIEWS NEUROSCIENCE

A Novel Mouse Model for Acute and Long-Lasting Consequences of Early Life Stress

(2008) Courtney J. Rice et al.   ENDOCRINOLOGY

Rapid Loss of Dendritic Spines after Stress Involves Derangement of Spine Dynamics by Corticotropin-Releasing Hormone

(2008) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Object recognition memory: Neurobiological mechanisms of encoding, consolidation and retrieval

(2008) Boyer D. Winters et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS