Article
Clinical Neurology
Rurui Wei, Yan Zhang, Peishan Li, Zeheng Xu, La Zhang, Yan He, Qinfen Wu, Youcai Shi, Yang Yuan, Abudula Aisha
Summary: This study investigated the relationship between substantia nigra signatures and clinical features in Parkinson's disease patients in a multiethnic region of China. The results showed differences in the substantia nigra hyperechogenicity (SNH) area based on age of onset, visual hallucinations, and UPDRS3.0 II scores. A high SNH area was found to be an independent risk factor for development of visual hallucinations, and there was a positive correlation between the SNH area and UPDRS3.0 II scores. Transcranial sonography has guiding significance in predicting clinical visual hallucination symptoms and activities of daily living in Parkinson's disease patients.
PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Sha Zhu, Yaxi Wang, Yinyin Jiang, Ruxin Gu, Min Zhong, Xu Jiang, Bo Shen, Jun Zhu, Jun Yan, Yang Pan, Li Zhang
Summary: This study aimed to explore the relationship between substantia nigra hyperechogenicity (SNH) and the clinical features of Parkinson's disease (PD). The results showed that SNH was significantly correlated with activities of daily living and gait impairment in Chinese patients with PD, suggesting the formation of SNH might be a dynamic biomarker reflecting disease severity.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Medicine, General & Internal
Li-Shu Wang, Teng-Fei Yu, Bin Chai, Wen He
Summary: This study evaluated the application of transcranial sonography (TCS) for the differential diagnosis of Parkinson disease (PD) and other movement disorders in Chinese individuals. The results showed that SN positivity effectively differentiated PD from ET, PSP, and MSA, while the incidence of lenticular hyperechoic area also played a role in distinguishing between these diseases.
CHINESE MEDICAL JOURNAL
(2021)
Article
Neurosciences
Ioanna Pachi, Vassilis Papadopoulos, Christos Koros, Athina Maria Simitsi, Anastasia Bougea, Maria Bozi, Nikos Papagiannakis, Rigas Filippos, Rigas Filippos Soldatos, Dimitra Kolovou, George Pantes, Nikolaos Scarmeas, Georgios Paraskevas, Konstantinos Voumvourakis, Sokratis G. Papageorgiou, Konstantinos Kollias, Nikos Stefanis, Leonidas Stefanis
Summary: Psychotic symptoms, mainly of minor nature, are highly common in the early stages of Parkinson's disease (PD). These symptoms are associated with cumulative non-motor symptoms, REM sleep behavior disorder (RBD), and depressive features.
JOURNAL OF PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Xishun Ma, Tongxia Li, Lizhen Du, Tongliang Han
Summary: Parkinson's disease is a common nervous system disease with motor retardation and resting tremor as its main manifestations. Early diagnosis of Parkinson's disease is difficult, but transcranial sonography has been widely used for its diagnosis and treatment. This article reviews the recent advances in the study of Parkinson's disease using transcranial sonography.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Hong-ling Gao, Yi Qu, Sheng-chong Chen, Qing-mei Yang, Jing-yi Li, An-yu Tao, Zhi-juan Mao, Zheng Xue
Summary: This study examined the association between third ventricular width measured by transcranial sonography (TCS) and cognitive decline in Parkinson's disease (PD) patients. The results showed a negative correlation between third ventricular width and Mini-Mental State Examination (MMSE) scores. Patients with a third ventricular width greater than 4.75 mm had a significantly higher risk of developing cognitive impairment compared to those with a smaller width. The findings suggest that third ventricular width based on TCS could serve as an independent predictor for cognitive decline in PD patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Neurosciences
Cristina del Toro Perez, Laura Amaya Pascasio, Antonio Arjona Padillo, Jesus Olivares Romero, Maria Victoria Mejias Olmedo, Javier Fernandez Perez, Manuel Payan Ortiz, Patricia Martinez-Sanchez
Summary: Literature research demonstrates that brainstem raphe hypoechogenicity is related to depression in both PD and non-PD patients, as well as overactive bladder. Substantia nigra hyperechogenicity is common in patients with visual hallucinations, and larger intracranial ventricles are correlated with dementia. The evaluation of the vagus nerve shows contradictory findings.
Article
Behavioral Sciences
Maria A. S. Paes, Denise H. Nicaretta, Regina M. P. Alvarenga, Ana L. Z. Rosso, Rodrigo T. Brisson, Rita C. L. Fernandes
Summary: The aim of this study was to compare a portable ultrasound (US) device and a traditional US for transcranial ultrasonography (CCT) in patients with Parkinson's disease (PD). The results showed good agreement between the measurements obtained with the portable US and the traditional equipment, and the measurement of SN echogenic area had good sensitivity and specificity for PD diagnosis.
BRAIN AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Jia-jing Wu, Hong Jin, Ying-qi Shao, Cheng-jie Mao, Jing Chen, Chun-feng Liu
Summary: Orthostatic hypotension is a common nonmotor symptom in patients with Parkinson's disease, with impacts on cognition and transcranial sonography findings. Older age is an independent risk factor for OH in PD patients, and there are differences in cognitive function and motor symptom scores between PD-OH and PD-NOH patients. The substantia nigra area may indicate different subtypes of PD or a tendency to develop parkinsonism syndrome.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Maria Diez-Cirarda, Alberto Cabrera-Zubizarreta, Ane Murueta-Goyena, Antonio P. Strafella, Rocio Del Pino, Marian Acera, Olaia Lucas-Jimenez, Naroa Ibarretxe-Bilbao, Beatriz Tijero, Juan Carlos Gomez-Esteban, Inigo Gabilondo
Summary: Visual hallucinations (VH) are present in up to 75% of Parkinson's disease (PD) patients. However, their neural bases and participation of the visual system in VH are not well-understood in PD. This study found specific functional and structural abnormalities within the visual system in PD patients with VH, which could potentially serve as biomarkers for VH in PD.
JOURNAL OF NEUROLOGY
(2023)
Review
Neurosciences
Francisco Nieto-Escamez, Esteban Obrero-Gaitan, Irene Cortes-Perez
Summary: Non-motor symptoms in Parkinson's disease (PD) include ocular, visuoperceptive, and visuospatial impairments. Ocular impairments affect vision and eye movement, while visuoperceptive impairments involve difficulties perceiving visual stimuli accurately and visuospatial impairments affect spatial relationships and judgement. PD patients also face attention and perceptual disturbances with visual stimuli. The neurobiological bases of visual-related disorders in PD are complex and not fully understood, with changes in cortical and subcortical regions and alterations in dopamine, acetylcholine, and serotonin systems potentially involved.
Article
Clinical Neurology
Adam Fry, Dharampreet Singh, Louis Manganas, Marc L. Gordon, Christopher Christodoulou, Hoi-Chung Leung, Guy J. Schwartz
Summary: This study found a high incidence of temporal lobe epileptiform discharges in Parkinson's disease patients with visual hallucinations compared to those without. This finding suggests a possible association with a epileptogenic focus in the visual cortex and highlights the potential use of antiepileptic drugs in treatment-refractory patients, similar to Charles Bonnet syndrome, temporal lobe epilepsy, and migraine with visual aura.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Alberto Cucca, Claudia Virginia Manara, Mauro Catalan, Marco Liccari, Lucia Antonutti, Tiziana Maria Isabella Lombardo, Valentina Cenacchi, Sophie Rangan, Serena Mingolo, Carmelo Crisafulli, Franca Dore, Mauro Murgia, Tiziano Agostini, Paolo Manganotti
Summary: Visual hallucinations are common symptoms of Parkinson's Disease, and are associated with impairments in perceptual processing and modulation. This study found that perceptual performance in PD patients is related to the presence of hallucinations, as well as abnormal top-down perceptual modulation.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Clinical Neurology
Wei Lin Toh, Caitlin Yolland, Caroline Gurvich, James Barnes, Susan L. Rossell
Summary: This study conducted a systematic review on non-visual hallucinations in Parkinson's disease, exploring their prevalence, phenomenology, and clinical-cognitive correlates. The findings revealed that non-visual hallucinations are prevalent in Parkinson's disease and have clinical significance, highlighting the need for further research and clinical attention.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Liangcheng Qu, Chuan Liu, Yiting Cao, Jingping Shi, Kuiying Yin, Weiguo Liu
Summary: Recent studies have found that functional connections are impaired in patients with Parkinson's disease accompanied by hallucinations even in the preclinical stage. This study investigated the impact of changes in functional connectivity between cognitive sub-regions of the cerebellum on cognitive performance in PD patients with hallucinations. Resting-state functional magnetic resonance imaging data were collected and a machine learning method was used to classify subjects based on cerebellar functional connectivity features. The results showed that FC within certain brain regions was increased in PD-H patients compared to healthy controls and PD-NH patients. These findings provide a promising and low-cost alternative for diagnosing preclinical PD-H and have implications for other degenerative brain disorders.
Article
Cardiac & Cardiovascular Systems
Dayang Wang, Xiaoqing Xu, Mingjing Zhao, Xian Wang
CARDIOVASCULAR PATHOLOGY
(2020)
Article
Integrative & Complementary Medicine
Xu Xiao-qing, Deng Wen-qi, Wang Da-Yang, Li Meng, Kou Dong-lei, Zhang Pei-tong
Summary: The study evaluated the effect of Chinese medicine treatment on survival time and quality of life in patients with small cell lung cancer. It showed that Chinese medicine treatment may help prolong the overall survival of patients and improve quality of life, providing preliminary evidence for its application in multi-disciplinary treatment for small cell lung cancer.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Dayang Wang, Chunyan Li, Xiaoqing Xu, Hui Xu, Congcong Guo, Jinping Wang, Jingyin Guo, Li Huang
Summary: In patients with stable coronary artery disease, the addition of Yugengtongyu granules to standard treatment significantly reduced the incidence of adverse cardiovascular events and improved quality of life. Compared to the control group, the experimental group had a lower rate of cardiovascular events and higher QOL scores.
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
(2021)
Article
Geriatrics & Gerontology
Mingqing Wei, Jingnian Ni, Jing Shi, Ting Li, Xiaoqing Xu, Chenmeng Li, Bin Qin, Dongsheng Fan, Hengge Xie, Zhong Wang, Yongyan Wang, Tao Lu, Jinzhou Tian
Summary: This study found that plasma REST protein levels are decreased in AD dementia patients, which is associated with memory impairment and left temporal lobe atrophy, and may have potential value for clinical diagnosis of AD dementia.