Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo

Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation

(2018) Yuan-Liang Zhang et al.   CELL RESEARCH

The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice

(2018) Xiaoli Zuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

(2018) Lenan Zhuang et al.   Nature Communications

H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

(2018) Dong Fang et al.   eLife

A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq

(2018) Christopher Daniel Green et al.   DEVELOPMENTAL CELL

Oncohistones: drivers of pediatric cancers

(2017) Faizaan Mohammad et al.   GENES & DEVELOPMENT

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas

(2017) Simon Papillon-Cavanagh et al.   NATURE GENETICS

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

(2017) Faizaan Mohammad et al.   NATURE MEDICINE

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

(2017) Andrea Piunti et al.   NATURE MEDICINE

Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase

(2016) Shuang Yang et al.   GENES & DEVELOPMENT

Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome

(2016) Alexey A. Soshnev et al.   MOLECULAR CELL

The Aging Epigenome

(2016) Lauren N. Booth et al.   MOLECULAR CELL

S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3

(2016) Hariharan Jayaram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

(2016) C. Lu et al.   SCIENCE

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

(2016) D. Fang et al.   SCIENCE

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

(2016) Neil Justin et al.   Nature Communications

A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading

(2016) Chun-Min Shan et al.   eLife

Haemopedia: An Expression Atlas of Murine Hematopoietic Cells

(2016) Carolyn A. de Graaf et al.   Stem Cell Reports

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

(2015) Tuncay Baubec et al.   NATURE

Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

(2015) L. Jiao et al.   SCIENCE

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Every amino acid matters: essential contributions of histone variants to mammalian development and disease

(2014) Ian Maze et al.   NATURE REVIEWS GENETICS

Plasticity of epithelial stem cells in tissue regeneration

(2014) C. Blanpain et al.   SCIENCE

Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling

(2014) H.-M. Herz et al.   SCIENCE

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

(2014) Kosuke Funato et al.   SCIENCE

H3K36 Histone Methyltransferase Setd2 Is Required for Murine Embryonic Stem Cell Differentiation toward Endoderm

(2014) Yuanliang Zhang et al.   Cell Reports

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis

(2013) Masayo Inagawa et al.   MECHANISMS OF DEVELOPMENT

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence

(2013) Min Ye et al.   NATURE CELL BIOLOGY

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

(2013) Sam Behjati et al.   NATURE GENETICS

A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb

(2013) A. R. Pengelly et al.   SCIENCE

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

(2013) P. W. Lewis et al.   SCIENCE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

(2012) K. Xu et al.   SCIENCE

UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development

(2012) Karl B. Shpargel et al.   PLoS Genetics

H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation

(2011) Wen Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

(2011) Jason Wray et al.   NATURE CELL BIOLOGY

Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression

(2010) Sara A. Miller et al.   MOLECULAR CELL

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state

(2009) S. Bilodeau et al.   GENES & DEVELOPMENT

Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells

(2009) Samuel Yao-Ming Ng et al.   IMMUNITY