Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis

Universal allosteric mechanism for Gα activation by GPCRs

(2015) Tilman Flock et al.   NATURE

Probing Gαi1 protein activation at single–amino acid resolution

(2015) Dawei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1

(2015) Ned Van Eps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for nucleotide exchange in heterotrimeric G proteins

(2015) R. O. Dror et al.   SCIENCE

Probing Gαi1 protein activation at single–amino acid resolution

(2015) Dawei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

(2014) Aashish Manglik et al.   CURRENT OPINION IN CELL BIOLOGY

A Conserved Phenylalanine as a Relay between the α5 Helix and the GDP Binding Region of Heterotrimeric GiProtein α Subunit

(2014) Ali I. Kaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Energetic analysis of the rhodopsin–G-protein complex links the α5 helix to GDP release

(2013) Nathan S Alexander et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantitative exploration of the molecular origin of the activation of GTPase

(2013) R. P. B et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq Complex

(2013) Mark R. Nance et al.   STRUCTURE

Myristoylation Exerts Direct and Allosteric Effects on Gα Conformation and Dynamics in Solution

(2012) Anita M. Preininger et al.   BIOCHEMISTRY

Signal Activation and Inactivation by the G  Helical Domain: A Long-Neglected Partner in G Protein Signaling

(2012) H. G. Dohlman et al.   Science Signaling

Biological Phosphoryl-Transfer Reactions: Understanding Mechanism and Catalysis

(2011) Jonathan K. Lassila et al.   Annual Review of Biochemistry

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation

(2011) Angeline M Lyon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit

(2011) N. Van Eps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic Scaffolding Mediated by a Phospholipase C-  and Gq Signaling Complex

(2010) G. L. Waldo et al.   SCIENCE

Transition State Structures and the Roles of Catalytic Residues in GAP-Facilitated GTPase of Ras As Elucidated by18O Kinetic Isotope Effects

(2009) Xinlin Du et al.   BIOCHEMISTRY

Simulated 18O kinetic isotope effects in enzymatic hydrolysis of guanosine triphosphate

(2009) A. V. Nemukhin et al.   BIOCHEMISTRY-MOSCOW

Structure and Function of Heterotrimeric G Protein-Regulated Rho Guanine Nucleotide Exchange Factors

(2009) M. Aittaleb et al.   MOLECULAR PHARMACOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Coordinating Speed and Amplitude in G-Protein Signaling

(2008) Elliott M. Ross   CURRENT BIOLOGY

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Molecular architecture of G o and the structural basis for RGS16-mediated deactivation

(2008) K. C. Slep et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein  -subunits

(2008) M. Soundararajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G protein inactive and active forms investigated by simulation methods

(2008) Kamil Khafizov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Recognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEF

(2008) Zhe Chen et al.   STRUCTURE

Coordinate Regulation of G Protein Signaling via Dynamic Interactions of Receptor and GAP

(2008) Marc Turcotte et al.   PLoS Computational Biology