Article
Materials Science, Multidisciplinary
Sobia Noreen, Arslan Maqbool, Irsah Maqbool, Afifa Shafique, Muhammad Muzamil Khan, Yasmeen Junejo, Bilal Ahmed, Maryam Anwar, Asma Majeed, Muhammad Abbas, Muhammad Naveed, Asadullah Madni
Summary: Nanotechnology is the emerging field that focuses on controlling material configuration at a reduced scale, and multifunctional mesoporous silica nanoparticles (MSNPs) have been shown to have great potential in tumor treatment and imaging. Functionalized mesoporous silica materials have rapidly advanced in imaging and therapeutic applications.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Crystallography
Melissa Venedicto, Jake Carrier, Ha Na, Chen-Yu Chang, Daniela R. Radu, Cheng-Yu Lai
Summary: Mesoporous silica nanoparticles (MSNs) are utilized as carriers in drug and gene delivery research for biomedical applications due to their high surface area, consistent particle size, and minimal toxicity. By incorporating disulfide (SS) bonds into the walls of MSNs, a dual pathway for drug release is provided. Various characterization methods are employed to study the effect of embedding disulfide bonds into MSNs. The study demonstrates that MSN-SS is a promising nanocarrier for controlled-release drug delivery with efficient pH-responsive drug release behavior.
Article
Biotechnology & Applied Microbiology
Xuqi Peng, Gan Lin, Yun Zeng, Zhao Lei, Gang Liu
Summary: Hepatocellular carcinoma is associated with poor prognosis, but early-stage patients have better survival rates. Mesoporous silica nanoparticles-based imaging agents have emerged as a promising tool for early detection of HCC, offering potential applications in clinical settings despite some challenges to overcome. Multi-modal imaging systems have been developed for enhanced spatial resolution and sensitivity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Ranjith Kumar Kankala, Ya-Hui Han, Hong-Ying Xia, Shi-Bin Wang, Ai-Zheng Chen
Summary: Mesoporous silica nanoparticles (MSNs) have great potential in biomedical applications, but traditional MSNs have limitations such as reduced drug encapsulation efficacy and poor degradability. Hierarchically-engineered MSNs have been developed by tuning the pore sizes, modifying the surfaces, and engineering the siliceous networks. These engineered MSNs have complex structures and can be applied in drug delivery, bioimaging, tissue engineering, and other fields.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Medicine, Research & Experimental
Yanmei Huang, Peng Li, Ruikang Zhao, Laien Zhao, Jia Liu, Zhuhong Zhang
Summary: This article reviews the recent research progress on the biomedical applications of silica nanoparticles (SiNPs). SiNPs have great potential in drug delivery, targeted cancer treatment, and disease diagnosis due to their controllable particle size, large surface area, and good biocompatibility. However, the toxicity mechanisms of SiNPs remain poorly understood and require further investigation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Hafiz Ahmed, Shyam Sudhakar Gomte, Eluri Prathyusha, A. Prabakaran, Mukta Agrawal, Amit Alexander
Summary: Mesoporous silica nanoparticles (MSNs) have unique properties that make them attractive to biomedical researchers. Over the past decade, these properties have been extensively explored in various biomedical applications, such as drug delivery, photodynamic therapy, biosensors, and tissue engineering. However, further in vivo studies are needed to analyze the potential adverse reactions and side effects of these nanoparticle-based drug delivery systems for clinical translation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Summary: Mesoporous silica nanoparticles (MSNs) as drug delivery agents show great potential in cancer treatment by enhancing efficacy and reducing side effects. Through the development of smart DDAs and the capability to efficiently trap cargo molecules, MSNs have a bright future in both the diagnosis and treatment of cancer.
Article
Chemistry, Multidisciplinary
Bianca Martins Estevao, Ivana Miletto, Noboru Hioka, Leonardo Marchese, Enrica Gianotti
Summary: The synthesis and characterization of amino-functionalized mesoporous silica nanoparticles can be achieved through co-condensation or post-synthesis grafting of 3-aminopropyltriethoxysilane. The homogeneous distribution of amino groups within the silica network is crucial for avoiding aggregation during further organic functionalization. Additionally, the formation of a protein corona on amino-modified nanoparticles can help prevent severe aggregation in biological media.
Review
Chemistry, Multidisciplinary
Kristina Zivojevic, Minja Mladenovic, Mila Djisalov, Mirjana Mundzic, Eduardo Ruiz-Hernandez, Ivana Gadjanski, Nikola Z. Knezevic
Summary: Research on targeted nanomaterials for cancer theranostics, particularly mesoporous silica nanoparticles (MSNs), has shown great potential for advanced nanostructures with multiple functions in cancer treatment. These nanoconstructs offer endless prospects for imaging and therapy applications, as well as novel trends in CRISPR/Cas9 systems delivery and gene editing in cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Jessica Andrea Flood-Garibay, Miguel A. Mendez-Rojas
Summary: The study reported the preparation of magnetic wrinkled mesoporous silica (MWMS) nanocomposites using different methods, and characterized their morphology and physical properties using various analytical techniques. The resulting MWMS nanocomposites show potential for biomedical applications as drug delivery systems or contrast agents for magnetic resonance imaging.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Pharmacology & Pharmacy
Xiaowei Xie, Tianxiang Yue, Wenting Gu, Weiyi Cheng, Li He, Weiye Ren, Fanzhu Li, Ji-Gang Piao
Summary: This paper discusses the use of surface-functionalized mesoporous silica nanoparticles (MSN) as delivery vehicles for siRNA in cancer therapy. The advantages of using MSNs for siRNA loading and strategies to improve cellular uptake and endosomal escape are highlighted. Attention is also paid to the exciting progress made by combining RNAi with other therapies to improve cancer therapeutic outcomes.
Review
Chemistry, Multidisciplinary
Miguel Gisbert-Garzaran, Maria Vallet-Regi
Summary: Mesoporous silica nanoparticles are widely used in cancer treatment, with a focus on redox-responsive systems. This trend in design includes biological rationale, gatekeeper types, and nucleic acid scaffold nanoparticles.
Review
Pharmacology & Pharmacy
Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Periyanaina Kesika, Natarajan Suganthy, Chaiyavat Chaiyasut
Summary: Complete recovery from infection, sepsis, injury, or trauma requires a vigorous inflammatory response. Nanoparticles have become an efficient medical tool for diagnosing, preventing, and treating diseases due to their unique interactions with biological molecules. Mesoporous silica nanoparticles (MSNs) play a significant role in nano therapy and have several advantages such as easy synthesis, loading, and biocompatibility. MSNs can be used as theranostics in immune-modulatory nano systems to diagnose and treat inflammatory diseases.
Review
Chemistry, Physical
Arezoo Sodagar Taleghani, Ali Taghvaie Nakhjiri, Mohammad Javad Khakzad, Seyed Mahdi Rezayat, Pedram Ebrahimnejad, Amir Heydarinasab, Azim Akbarzadeh, Azam Marjani
Summary: In recent decades, significant progress has been made in cancer treatment, but finding more effective therapies is crucial. The application of drug delivery nanovehicles, particularly mesoporous silica nanoparticles (MSNPs), shows promise in reducing side effects. MSNPs possess excellent characteristics that make them suitable for targeted and stimuli responsive drug delivery in cancer treatment.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Engineering, Biomedical
Yi Feng, Zhen Liao, Mengyue Li, Hanxi Zhang, Tingting Li, Xiang Qin, Shun Li, Chunhui Wu, Fengming You, Xiaoling Liao, Lulu Cai, Hong Yang, Yiyao Liu
Summary: In recent years, researchers have developed novel nanoparticles for diagnostic applications and therapeutic purposes. This review focuses on the synthesis of mesoporous silica nanoparticles (MSNs) for drug delivery and smart response applications, including the fabrication of ordered, hollow, core-shell structured, dendritic, and biodegradable MSNs. The review also discusses recent research progress in designing functional MSN materials with various controlled release mechanisms in anticancer therapy, as well as their bioimaging capabilities and potential as delivery vehicles.
ADVANCED HEALTHCARE MATERIALS
(2023)
