Journal
NANO
Volume 14, Issue 11, Pages -Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S1793292019501455
Keywords
Polymer; starch; mPEG; nanomicelle; pH-responsive
Funding
- Guangxi Biological Polysaccharide Separation, Purification and Modification Research Platform [GKZY18076005]
- Key Project of Graduate Education Innovation Program of Guangxi University for Nationalities [gxun-chxzs2017127, gxunchxzs2018049]
- Guangxi University Students Innovation and Entrepreneurship Training Program [20190608180, 20190608179]
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Amphiphilic polymer carriers (PEG-St-R) were prepared from cassava starch and their pH response was investigated. First, hydrophobic tapioca starch polymer (St-R) was prepared with octyl acyl as the hydrophobic group. The hydrophilic group polyethylene glycol (mPEG) was then introduced into the polymer by esterification to produce amphiphilic tapioca starch polymer (PEG-St-R). Its self-assembly behavior was characterized using fluorescent probes. The morphology of PEG-St-R was investigated by transmission electron microscopy (TEM). Loading of the anti-cancer drug curcumin was used to assess the delivery and slow-release performance of the amphiphilic tapioca starch polymer. Cumulative drug release was explored at various pH conditions, with the greatest release from drug-loaded micelles being observed under acidic conditions and stable in a neutral environment. These results provide a theoretical basis for the preparation of pH-responsive nanomicelle carriers, and a platform for the preparation of novel amphiphilic starch-based polymers.
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