Journal
BIOPOLYMERS
Volume 106, Issue 6, Pages 901-909Publisher
WILEY
DOI: 10.1002/bip.22878
Keywords
oral absorption; permeability; cyclic peptide
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Funding
- Australian Research Council (ARC) Linkage Grant [LP110200213]
- National Health and Medical Research Council (NHMRC) Grant [APP1076136, APP1107403]
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Achieving high oral bioavailability for drugs is a key design objective in drug development. It is not surprising then that with the growing expectation of peptides as future drugs, there has also been an increasing interest in developing oral peptide therapeutics. Brought to the fore are questions such as what makes peptides orally bioavailable and how this can be achieved; questions which have inspired research into the area for decades. Early research in the area focused on linear peptides with more recent literature focusing on cyclic peptides, motivated in part by cyclic peptides like cyclosporine A that have demonstrated drug-like oral bioavailability. In this review, we take a look at research on the oral bioavailability of peptides, focusing on factors that affect passive permeability. (C) 2016 Wiley Periodicals, Inc.
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