Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases

Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation

(2019) Sang R. Lee et al.   BMC CANCER

Effect of oral phytoestrogens on endometrial thickness and breast density of perimenopausal and postmenopausal women: a systematic review and meta-analysis

(2019) Evangelia Mareti et al.   MATURITAS

Estrogen receptor genes polymorphisms determine serum lipid profile in healthy postmenopausal women treated with calcium, vitamin D, and genistein

(2019) Ricardo Usategui‐Martín et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effectiveness of genistein supplementation on metabolic factors and antioxidant status in postmenopausal women with type-2 diabetes mellitus

(2019) Hassan Braxas et al.   Canadian Journal of Diabetes

The phytoestrogen genistein affects inflammatory-related genes expression depending on the ERα/ERβ ratio in breast cancer cells

(2019) Daniel Gabriel Pons et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Genistein combined with FOLFOX or FOLFOX–Bevacizumab for the treatment of metastatic colorectal cancer: phase I/II pilot study

(2019) Sofya Pintova et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Daidzein and genistein have differential effects in decreasing whole body bone mineral density but had no effect on hip and spine density in premenopausal women: A 2-year randomized, double-blind, 3placebo-controlled study

(2019) Fatima Nayeem et al.   NUTRITION RESEARCH

Complementary and alternative medicine for natural and treatment-induced vasomotor symptoms: An overview of systematic reviews and meta-analyses

(2019) Ping-Ping Guo et al.   Complementary Therapies in Clinical Practice

Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer

(2018) Karen K. L. Chan et al.   Cancer Cell International

Postmenopausal endometriosis: drawing a clearer clinical picture

(2018) D. A. Tan et al.   CLIMACTERIC

Impact of treatment with a Protein Tyrosine Kinase Inhibitor (Genistein) on acute and chronic experimental Schistosoma mansoni infection

(2018) Maysa Mohamed Kamel Sobhy et al.   EXPERIMENTAL PARASITOLOGY

Soybean soluble polysaccharide enhances absorption of soybean genistein in mice

(2018) Yalong Lu et al.   FOOD RESEARCH INTERNATIONAL

Effects of Phytoestrogens on Depressive Symptoms in Climacteric Women: A Meta-analysis of Randomized Controlled Trials

(2018) Belinda Yuh-Wen Su et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract Obesity

(2018) Veronica Valli et al.   Oxidative Medicine and Cellular Longevity

G protein-coupled estrogen receptor is involved in the anti-inflammatory effects of genistein in microglia

(2018) Zhong-Rui Du et al.   PHYTOMEDICINE

A Review of Phytoestrogens and Their Association With Pelvic Floor Conditions

(2018) Olivia Cardenas-Trowers et al.   Female Pelvic Medicine and Reconstructive Surgery

Genistein Improves the Major Depression through Suppressing the Expression of miR-221/222 by Targeting Connexin 43

(2018) Fang Shen et al.   Psychiatry Investigation

Dietary Genistein Alleviates Lipid Metabolism Disorder and Inflammatory Response in Laying Hens With Fatty Liver Syndrome

(2018) Zengpeng Lv et al.   Frontiers in Physiology

Long-term ovariectomy increases anxiety- and despair-like behaviors associated with lower Fos immunoreactivity in the lateral septal nucleus in rats

(2018) Abraham Puga-Olguín et al.   BEHAVIOURAL BRAIN RESEARCH

Dietary intake of isoflavones and coumestrol and the risk of prostate cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

(2017) Michael K. Reger et al.   INTERNATIONAL JOURNAL OF CANCER

Genistein alleviates anxiety-like behaviors in post-traumatic stress disorder model through enhancing serotonergic transmission in the amygdala

(2017) Zhong-Min Wu et al.   PSYCHIATRY RESEARCH

Genistein Supplementation and Cardiac Function in Postmenopausal Women with Metabolic Syndrome: Results from a Pilot Strain-Echo Study

(2017) Cesare de Gregorio et al.   Nutrients

The Phytoestrogen Genistein Produces Similar Effects as 17β-Estradiol on Anxiety-Like Behavior in Rats at 12 Weeks after Ovariectomy

(2017) Juan Francisco Rodríguez-Landa et al.   Biomed Research International

The Effects and Action Mechanisms of Phytoestrogens on Vasomotor Symptoms During Menopausal Transition: Thermoregulatory Mechanism

(2017) Haryati Ahmad Hairi et al.   CURRENT DRUG TARGETS

Vasomotor and sexual symptoms in older Australian women: a cross-sectional study

(2016) Berihun M. Zeleke et al.   FERTILITY AND STERILITY

Use of Plant-Based Therapies and Menopausal Symptoms

(2016) Oscar H. Franco et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Menopausal vasomotor symptoms are associated with poor self-assessed work ability

(2016) Pragya Gartoulla et al.   MATURITAS

Genistein inhibits A549 human lung cancer cell proliferation via miR-27a and MET signaling

(2016) Yang Yang et al.   Oncology Letters

EMAS position statement: Non-hormonal management of menopausal vasomotor symptoms

(2015) Gesthimani Mintziori et al.   MATURITAS

Hormone Replacement Therapy, Likely Neither Angel Nor Demon

(2015) Mitchell S. Wachtel et al.   PLoS One

Genistein suppresses FLT4 and inhibits human colorectal cancer metastasis

(2015) Xiao Xiao et al.   Oncotarget

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

(2015) Nicole M. Davis et al.   Oncotarget

Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells

(2014) Shulhn-Der Wang et al.   BMC Complementary and Alternative Medicine

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Perinatal exposure to genistein affects the normal development of anxiety and aggressive behaviors and nitric oxide system in CD1 male mice

(2014) Alicia Rodriguez-Gomez et al.   PHYSIOLOGY & BEHAVIOR

Association between Soy Isoflavone Intake and Breast Cancer Risk for Pre- and Post-Menopausal Women: A Meta-Analysis of Epidemiological Studies

(2014) Meinan Chen et al.   PLoS One

Genistein and endothelial function in postmenopausal women with metabolic syndrome

(2013) Concetta Irace et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Adipokines, adiposity, and vasomotor symptoms during the menopause transition: findings from the Study of Women's Health Across the Nation

(2013) Rebecca C. Thurston et al.   FERTILITY AND STERILITY

Genistein in the Metabolic Syndrome: Results of a Randomized Clinical Trial

(2013) Francesco Squadrito et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Involvement of Nuclear Factor κB (NF-κB) in the Downregulation of Cyclo-Oxygenase-2 (COX-2) by Genistein in Gastric Cancer Cells

(2013) Y-S Li et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Genistein inhibits hepatocellular carcinoma cell migration by reversing the epithelial-mesenchymal transition: Partial mediation by the transcription factor NFAT1

(2013) Weiqi Dai et al.   MOLECULAR CARCINOGENESIS

Lose dose genistein inhibits glucocorticoid receptor and ischemic brain injury in female rats

(2013) Rengfei Shi et al.   NEUROCHEMISTRY INTERNATIONAL

Genistein Induces G2/M Arrest in Gastric Cancer Cells by Increasing the Tumor Suppressor PTEN Expression

(2013) Yan-Long Liu et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Genistein exhibits anti-cancer effects via down-regulating FoxM1 in H446 small-cell lung cancer cells

(2013) Tiantian Tian et al.   TUMOR BIOLOGY

Genistein Affects Histone Modifications on Dickkopf-Related Protein 1 (DKK1) Gene in SW480 Human Colon Cancer Cell Line

(2012) Huan Wang et al.   PLoS One

Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity

(2011) Wentao Qi et al.   BMC CANCER

Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta-analysis and systemic review

(2011) Yu-Hung Chang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Genistein attenuates WNT signaling by up-regulating sFRP2 in a human colon cancer cell line

(2011) Yukun Zhang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Isoflavones as Apoptosis Inducers in Human Hepatoma HuH-7 Cells

(2011) Tayyab A. Mansoor et al.   PHYTOTHERAPY RESEARCH

Genistein Arrests Cell Cycle Progression of A549 Cells at the G2/M Phase and Depolymerizes Interphase Microtubules through Binding to a Unique Site of Tubulin

(2010) Sumita Mukherjee et al.   BIOCHEMISTRY

Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress

(2010) Aya KAGEYAMA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Genistein reduced the neural apoptosis in the brain of ovariectomised rats by modulating mitochondrial oxidative stress

(2010) Yan-Hong Huang et al.   BRITISH JOURNAL OF NUTRITION

Soy Consumption and Colorectal Cancer Risk in Humans: A Meta-Analysis

(2010) L. Yan et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Genistein Aglycone Does Not Affect Thyroid Function: Results from a Three-Year, Randomized, Double-Blind, Placebo-Controlled Trial

(2010) Alessandra Bitto et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genistein Induces Estrogen-Like Effects in Ovariectomized Rats but Fails to Increase Cardiac GLUT4 and Oxidative Stress

(2010) Layla Al-Nakkash et al.   JOURNAL OF MEDICINAL FOOD

The effect of synthetic genistein on menopause symptom management in healthy postmenopausal women: A multi-center, randomized, placebo-controlled study

(2010) Malkanthi Evans et al.   MATURITAS

Norepinephrine and Serotonin Transporter Genes: Impact on Treatment Response in Depression

(2010) Anna Baffa et al.   NEUROPSYCHOBIOLOGY

Global phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways

(2010) Guang-Rong Yan et al.   PROTEOMICS

Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis

(2009) Lin Yan et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genistein and β-carotene enhance the growth-inhibitory effect of trichostatin A in A549 cells

(2009) Rong-Jen Shiau et al.   EUROPEAN JOURNAL OF NUTRITION

Soy Food Consumption and Risk of Prostate Cancer: A Meta-Analysis of Observational Studies

(2009) Ye Won Hwang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Anxiolytic-like effect of phytoestrogen genistein in rats with long-term absence of ovarian hormones in the black and white model

(2009) Juan Francisco Rodríguez-Landa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Multi-targeted therapy of cancer by genistein

(2008) Sanjeev Banerjee et al.   CANCER LETTERS

Effects of phytoestrogen genistein on cytogenetic biomarkers in postmenopausal women: 1 year randomized, placebo-controlled study

(2008) Marco Atteritano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Diagnosis and Treatment of Hepatocellular Carcinoma

(2008) Hashem B. El-Serag et al.   GASTROENTEROLOGY

Breast Safety and Efficacy of Genistein Aglycone for Postmenopausal Bone Loss: A Follow-Up Study

(2008) Herbert Marini et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Differential Effect of the Phytoestrogen Genistein on Cardiovascular Risk Factors in Postmenopausal Women: Relationship with the Metabolic Status

(2008) Paola Villa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM