Review
Pharmacology & Pharmacy
Jing Chen, Bixin Shen, Zhengli Jiang
Summary: This article systematically summarizes the clinical application and pharmacological mechanism of Shenling BaiZhu powder (SLBZP) in the treatment of ulcerative colitis (UC). The results show that SLBZP has a significant therapeutic effect against UC with minimal adverse reactions. However, there are various shortcomings in the existing research, including a lack of uniform standard and insufficient data from clinical trials.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei-jie Lv, Yi-mu Ma, Jie-yi Huang, Shi-qi He, Shu-peng Li, Jin Lin, Rong Chen, Jian-chi Lun, Ju Liu, Shi-ning Guo
Summary: In this study, it was found that Shenling Baizhu San polysaccharides (SP) effectively improved colitis in mice by regulating tryptophan metabolic function of their gut microbiota. This effect was dependent on the gut microbiota and could be transferred through fecal microbiota transplantation (FMT).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Plant Sciences
Yuquan Mao, Guojie Hu, Qingyan Meng, Xiaoyuan Li, Xiaowei Sun, Jie Zhou, Tingting Zhang, Hui Liu, Chunhong Wang, Xin Du
Summary: The meta-analysis showed that the modified SBS could improve exercise endurance and life quality scores of stable COPD patients, and showed potential benefits in pulmonary function compared to the original SBS.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Mao-xing Pan, Chui-yang Zheng, Yuan-jun Deng, Kai-rui Tang, Huan Nie, Ji-qian Xie, Dong-dong Liu, Gui-fang Tu, Qin-he Yang, Yu-pei Zhang
Summary: SLBZP supplementation can reduce body weight, serum free fatty acid, and insulin resistance index, as well as ameliorate liver microcirculation and ultrastructural abnormalities. The study suggests that SLBZP may be beneficial for the prevention and treatment of inflammatory damage and associated diseases.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Plant Sciences
Chunhua Jiao, Qianwen Zhang, Mengjiao Yang, Jingjing Ma, Xiaojing Zhao, Nana Tang, Mingxin Dai, Qingyu Li, Zhenzhou Jiang, Xin Huang, Hongjie Zhang, Lixin Sun
Summary: The combination of SBS and mesalamine significantly improves clinical signs of UC by modulating gut microbiota and tryptophan metabolites levels.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Oncology
Hui Wang, Yen-Nien Hou, Mingxiao Yang, Ye Feng, Yi Lily Zhang, Colleen M. Smith, Wei Hou, Jun J. Mao, Gary Deng
Summary: This study evaluated the efficacy and safety of Shenling Baizhu San (SBS), a Chinese herbal formula, in treating chronic diarrhea. The results showed that SBS, either combined with or without conventional medicine, significantly improved patient-reported satisfaction and had no increased risk of adverse events. However, more rigorous and powered research is needed to confirm the effects of SBS in specific populations with chronic diarrhea symptoms.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Veterinary Sciences
Weijie Lv, Yimu Ma, Yingwen Zhang, Tianze Wang, Jieyi Huang, Shiqi He, Hongliang Du, Shining Guo
Summary: The study examined the effects of Shenling Baizhu San (SLBZS) fermented by Lactobacillus plantarum on the gut microbiota, antioxidant capacity, and intestinal barrier function of yellow-plumed broilers. The results showed that the addition of fermented SLBZS significantly improved the growth performance, lymphoid organ index, and antioxidant capacity of the broilers. Furthermore, it positively affected the intestinal health by increasing the villus height/crypt depth of the ileum and the expression of tight junction.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Mingmei Shao, Yifei Lu, Hongjiao Xiang, Junmin Wang, Guang Ji, Tao Wu
Summary: NAFLD, a common chronic liver disease, often coexists with insulin resistance-related diseases, posing serious health threats. Developing more efficient diagnostic methods for early detection of NAFLD is crucial. Traditional Chinese medicine can improve symptoms and protect target organs, while metabolomics provides valuable biomarkers for NAFLD diagnosis and potential mechanisms of Chinese medicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Zheng Yao, Jia Guo, Bing Du, Li Hong, Ying Zhu, Xiaoyi Feng, Yuanlu Hou, Anhua Shi
Summary: This study investigated the effects of intestinal flora and its metabolites on non-alcoholic fatty liver disease (NAFLD) and the therapeutic effect of Shenling Baizhu powder (SLBZP) on NAFLD. The results showed that short-chain fatty acids produced by intestinal flora metabolism improved liver mitochondrial energy metabolism through regulating the UCP2/AMPK/IF1 signaling pathway, thereby reducing liver lipid deposition and increasing liver ATP level in NAFLD patients.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Integrative & Complementary Medicine
Xiao Yi, Zhang Kui, Zhu Si-yu, Deng Xiang-liang, Chen Xiao-yin, Fu Nan-lin, Chen Jia
Summary: High-dose Shenling Baizhu Powder showed ameliorating effects on Pi-deficiency-induced functional diarrhea in rats, potentially due to its modulation of intestinal absorption function and adaptive immunity in mesenteric lymph nodes.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Honglin Zhou, Cheng Ma, Cheng Wang, Lihong Gong, Yafang Zhang, Yunxia Li
Summary: Non-alcoholic fatty liver disease (NAFLD) is gradually becoming one of the most common chronic liver diseases in the world due to the improvement of living standards and changes in eating habits. Traditional Chinese medicines (TCM) have attracted attention for their multi-target and multi-channel mechanisms in treating NAFLD, showing potential through regulating various pathways for ameliorating the disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Ke Zhu, Yongsong Guo, Chenghao Zhao, Shixin Kang, Jialiang Li, Jiexin Wang, Zhaohui Tang, Bing Lin, Weihong Li
Summary: The phlegm-dampness constitution is independently associated with NAFLD, suggesting it may be a risk factor. Further longitudinal studies are needed to confirm this relationship. Other biased TCM constitutions were not significantly associated with NAFLD.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Nutrition & Dietetics
Qiongbo Wu, Zihao Chen, Yi Ding, Yunting Tang, Yawei Cheng
Summary: This article summarizes the mechanism and application of Traditional Chinese Medicine in the regulation of non-alcoholic fatty liver disease through the ferroptosis pathway.
FRONTIERS IN NUTRITION
(2022)
Article
Integrative & Complementary Medicine
Daxing Gu, Shanshan Zhou, Lili Yao, Ying Tan, Xingzi Chi, Dayou Shi, Shining Guo, Cui Liu
Summary: The study demonstrated that SLBZS could effectively reduce colon injury, increase antioxidant capacity, and regulate gut microbiota in a rat model of ulcerative colitis.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Erika Dorochow, Nico Kraus, Nicolas Chenaux-Repond, Sandra Pierre, Anja Kolbinger, Gerd Geisslinger, Cristina Ortiz, Christoph Welsch, Jonel Trebicka, Robert Gurke, Lisa Hahnefeld, Sabine Klein, Klaus Scholich
Summary: Non-alcoholic steatohepatitis (NASH) and alcoholic steatohepatitis (ASH), the leading causes of liver disease, were studied to identify disease-specific pathomechanisms. Analysis of lipidome, metabolome, and immune cell recruitment in livers in both diseases revealed comparable disease severities but distinct immune responses. NASH exhibited higher lipid storage, oxidative stress, and elevated levels of tryptophan and its anti-inflammatory metabolite, kynurenine. In contrast, ASH showed increased L-homoarginine levels indicating a cardiovascular response mechanism. These findings provide insights into the molecular mechanisms underlying NASH and ASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)