Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α-conotoxin

Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins

(2015) Muharrem Akcan et al.   BIOPOLYMERS

Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability

(2015) Conan K. Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins

(2014) Kalyana B. Akondi et al.   CHEMICAL REVIEWS

Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3

(2014) Brad R. Green et al.   FEBS Journal

Semienzymatic Cyclization of Disulfide-rich Peptides Using Sortase A

(2014) Xinying Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABABreceptor activation

(2014) Géza Berecki et al.   JOURNAL OF GENERAL PHYSIOLOGY

Biodiversity of Cone Snails and Other Venomous Marine Gastropods: Evolutionary Success Through Neuropharmacology

(2013) Baldomero M. Olivera et al.   Annual Review of Animal Biosciences

Dissecting a role of evolutionary-conserved but noncritical disulfide bridges in cysteine-rich peptides using ω-conotoxin GVIA and its selenocysteine analogs

(2012) Konkallu Hanumae Gowd et al.   BIOPOLYMERS

Engineering of Conotoxins for the Treatment of Pain

(2012) Bodil B. Carstens et al.   CURRENT PHARMACEUTICAL DESIGN

Conotoxin engineering: dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability

(2012) Zoltan Dekan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding

(2011) Aline Dantas de Araujo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SwissParam: A fast force field generation tool for small organic molecules

(2011) Vincent Zoete et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Effects of Cyclization on Stability, Structure, and Activity of α-Conotoxin RgIA at the α9α10 Nicotinic Acetylcholine Receptor and GABABReceptor

(2011) Reena Halai et al.   JOURNAL OF MEDICINAL CHEMISTRY

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

(2011) Tina R White et al.   Nature Chemical Biology

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

(2011) Q. Kaas et al.   NUCLEIC ACIDS RESEARCH

Mastering the Canonical Loop of Serine Protease Inhibitors: Enhancing Potency by Optimising the Internal Hydrogen Bond Network

(2011) Joakim E. Swedberg et al.   PLoS One

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stabilization of α-Conotoxin AuIB: Influences of Disulfide Connectivity and Backbone Cyclization

(2010) Erica S. Lovelace et al.   ANTIOXIDANTS & REDOX SIGNALING

Improving the Stability of α-Conotoxin AuIB Through N-to-C Cyclization: The Effect of Linker Length on Stability and Activity at Nicotinic Acetylcholine Receptors

(2010) Christopher J. Armishaw et al.   ANTIOXIDANTS & REDOX SIGNALING

μ-Conotoxin KIIIA Derivatives with Divergent Affinities versus Efficacies in Blocking Voltage-Gated Sodium Channels

(2010) Min-Min Zhang et al.   BIOCHEMISTRY

Solving the α-Conotoxin Folding Problem: Efficient Selenium-Directed On-Resin Generation of More Potent and Stable Nicotinic Acetylcholine Receptor Antagonists

(2010) Markus Muttenthaler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conopeptide characterization and classifications: An analysis using ConoServer

(2010) Quentin Kaas et al.   TOXICON

Integrated Oxidative Folding of Cysteine/Selenocysteine Containing Peptides: Improving Chemical Synthesis of Conotoxins

(2009) Aleksandra Walewska et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Establishing regiocontrol of disulfide bond isomers of α-conotoxin ImI via the synthesis of N-to-C cyclic analogs

(2009) Christopher J. Armishaw et al.   BIOPOLYMERS

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

(2008) Rose Hayeshi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Caco-2 cell monolayer: usefulness and limitations

(2008) Huadong Sun et al.   Expert Opinion on Drug Metabolism & Toxicology

Analgesic  -Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABAB Receptor Activation

(2008) B. Callaghan et al.   JOURNAL OF NEUROSCIENCE

Validation and application of Caco-2 assays for thein vitroevaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions

(2008) R. Elsby et al.   XENOBIOTICA

Effect of P‐Glycoprotein Expression Levels on the Concentration‐Dependent Permeability of Drugs to the Cell Membrane

(2007) Yoshiyuki Shirasaka et al.   JOURNAL OF PHARMACEUTICAL SCIENCES