Journal
MOLECULES
Volume 24, Issue 23, Pages -Publisher
MDPI
DOI: 10.3390/molecules24234271
Keywords
Neonauclea reticulata; iridoid; bis-iridoid; neonanin; reticunin; RAW264.7
Funding
- Taiwan Ministry of Health andWelfare Clinical Trial Center [MOHW108-TDU-B-212-133004]
- Chinese Medicine Research Center, China Medical University from The Featured Areas Research Center Program within Ministry of Education (MOE) in Taiwan [CMRC-CHM-4]
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One new iridoid, namely neonanin C (1) one monocyclic iridoid ring-opened derivative namely neonanin D (2), two new bis-iridoid derivatives namely reticunin A (3) and reticunin B (4) with sixteen known compounds (5-20) were isolated from the stems of Neonauclea reticulata (Havil.) Merr. These new structures were determined by the detailed analysis of spectroscopic data and comparison with the data of known analogues. Compounds 1-20 were evaluated for inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages cell line. The results showed that all compounds exhibited no obvious cytotoxicity compared to the control group and five compounds including isoboonein (7), syringaresinol (10), (+)-medioresinol (12), protocatechuic acid (14) and trans-caffeic acid (15) exhibited inhibitory activities with IC50 values at 86.27 +/- 3.45; 9.18 +/- 1.90; 76.18 +/- 2.42; 72.91 +/- 4.97 and 95.16 +/- 1.20 mu g/mL, respectively.
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