Copper bis-Dipyridoquinoxaline Is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor Groove

Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination

(2018) Creina Slator et al.   NUCLEIC ACIDS RESEARCH

Polypyridyl-based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease

(2018) Nicolo Zuin Fantoni et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Innovative DNA-Targeted Metallo-Prodrug Strategy combining Histone Deacetylase Inhibition with Oxidative Stress

(2018) Tadhg J.P. McGivern et al.   MOLECULAR PHARMACEUTICS

Triggering autophagic cell death with a di-manganese(II) developmental therapeutic

(2017) Creina Slator et al.   Redox Biology

The Cambridge Structural Database

(2016) Colin R. Groom et al.   Acta Crystallographica Section B-Structural Science Crystal Engineering and Materials

[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction

(2015) Creina Slator et al.   ACS Chemical Biology

Protein engineering with artificial chemical nucleases

(2015) Ruth Larragy et al.   CHEMICAL COMMUNICATIONS

SHELXT– Integrated space-group and crystal-structure determination

(2015) George M. Sheldrick   Acta Crystallographica A-Foundation and Advances

Crystal structure refinement withSHELXL

(2015) George M. Sheldrick   Acta Crystallographica Section C-Structural Chemistry

DNA oxidation profiles of copper phenanthrene chemical nucleases

(2015) Zara Molphy et al.   Frontiers in Chemistry

Copper Phenanthrene Oxidative Chemical Nucleases

(2014) Zara Molphy et al.   INORGANIC CHEMISTRY

A new phenanthroline–oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction

(2013) Malachy McCann et al.   CHEMICAL COMMUNICATIONS

Regulating Bioactivity of Cu2+ Bis-1,10-phenanthroline Artificial Metallonucleases with Sterically Functionalized Pendant Carboxylates

(2013) Andreea Prisecaru et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(μ-terephthalate)(1,10-phen)4]2+

(2012) Andreea Prisecaru et al.   CHEMICAL COMMUNICATIONS

Deciphering the Antimicrobial Activity of Phenanthroline Chelators

(2012) M. McCann et al.   CURRENT MEDICINAL CHEMISTRY

Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2′-dipyridyl

(2012) Andrew Kellett et al.   FREE RADICAL BIOLOGY AND MEDICINE

Copper(II) Complexes of Salicylic Acid Combining Superoxide Dismutase Mimetic Properties with DNA Binding and Cleaving Capabilities Display Promising Chemotherapeutic Potential with Fast Acting in Vitro Cytotoxicity against Cisplatin Sensitive and Resistant Cancer Cell Lines

(2012) Mark O’Connor et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(ii) and silver(i) complexes

(2012) Malachy McCann et al.   Toxicology Research

Dicopper(II) complexes showing DNA hydrolase activity and monomeric adduct formation with bis(4-nitrophenyl)phosphate

(2011) Mithun Roy et al.   INORGANICA CHIMICA ACTA

Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development

(2011) Andrew Kellett et al.   MedChemComm

Activation of DNA Carbon−Hydrogen Bonds by Metal Complexes

(2010) Marguerite Pitié et al.   CHEMICAL REVIEWS

Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with ‘self-activating’ metallo-nuclease and DNA binding properties

(2010) Andrew Kellett et al.   DALTON TRANSACTIONS

Influence of counter anions on structural, spectroscopic and electrochemical behaviours of copper(II) complexes of dipyrido[3,2-f: 2′,3′-h]-quinoxaline (dpq)

(2008) Papu Biswas et al.   POLYHEDRON