Article
Biochemistry & Molecular Biology
Haitao Fan, Meng Sun, Jie Li, Shuofeng Zhang, Guangzhong Tu, Kechun Liu, Qing Xia, Yanyan Jiang, Bin Liu
Summary: A new polysaccharide, named SP800201, was isolated from Saposhnikoviae Radix. The polysaccharide consisted of monosaccharides including Gal, GalA, Ara, and Rha. Both cell and zebrafish experiments demonstrated the immunomodulatory activity of SP800201.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Jiankuan Li, Yan Wang, Jiaojiao Ji, Lingya Cao, Yune Bai, Jianping Gao
Summary: The research identified a glucan named CPC from the roots of Codonopsis pilosula, with a structure of 1,4-linked alpha-D-glucose backbone and 1,6-linked beta-D-glucose branched chains. Additionally, CPC exhibited significant induction on immune-related indicators, indicating its potential benefits for regulating human immune health.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Yan Zhou, Shengchao Wang, Weisheng Feng, Zhenling Zhang, Hongwei Li
Summary: The structures and immunomodulatory activities of two polysaccharides from Rehmanniae Radix Praeparata were investigated. Both SDH-WA and SDH-0.2A showed no cytotoxic effects on RAW264.7 cells, but significantly promoted phagocytic activity and improved lysozyme activity. They also dose-dependently stimulated the production of TNF-alpha and IL-6, while attenuating the secretion of various immune factors by lipopolysaccharide-induced RAW264.7 cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Plant Sciences
Aliya Sheik, Kwanwoo Kim, Ganji Lakshmi Varaprasad, Hoomin Lee, Suheon Kim, Eunsu Kim, Jin-Yong Shin, Seo Yeong Oh, Yun Suk Huh
Summary: Astragalus membranaceus, as a traditional herb with a long history in cancer treatment, has attracted researchers' attention for its immunomodulatory effects and potential in alleviating cancer-related fatigue. Its natural phytoconstituents show high anti-cancer activity and have been studied in clinical trials for overcoming the toxic effects of chemotherapy drugs.
Review
Chemistry, Medicinal
Chun-Xiao Li, Ying Liu, Yu-Zhen Zhang, Jing-Chun Li, Jiang Lai
Summary: This review provides a comprehensive overview of the research progress on the immunomodulatory effect of Astragalus polysaccharide. It summarizes the effects of Astragalus polysaccharide on central and peripheral immune organs, as well as various immune cells. Astragalus polysaccharide shows promising potential for the treatment of diseases, particularly in the field of cancer.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Juan Yu, Xiao-dan Dong, Jian-shuang Jiao, Hai-yu Ji, An-jun Liu
Summary: The Astragalus membranaceus polysaccharide (APS4) shows direct cytotoxicity on various cancer cells and has potential therapeutic effects on solid tumors. Through experiments on S180 tumor-bearing mice, it was found that APS4 can regulate the immune system, inhibit solid tumor growth, and promote apoptosis of tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Wen Zhang, Chaoying Lu, Shuhui Cai, Yaru Feng, Jinjun Shan, Liuqing Di
Summary: Aconiti Lateralis Radix Praeparata (Fuzi) is a traditional herbal medicine widely used in China and other Asian countries, with considerable anticancer, anti-inflammatory, and analgesic effects. Its main components, alkaloids and polysaccharides, have been shown to induce apoptosis and autophagy, inhibit proliferation, migration and invasion, regulate immune function, and affect energy metabolism, making them attractive candidates for anticancer drug development.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wanwan Xiao, Pingfan Zhou, Xiaoshuang Wang, Ruizhi Zhao, Yan Wang
Summary: This study investigated the effects of four different extraction methods on the polysaccharides of Platycodon grandiflorum. The results showed that the extraction method had a significant impact on yield, characteristics, and immunoregulatory activity. Polysaccharides with lower molecular weights and higher galacturonic acid content exhibited better immune-stimulating activity. The AAE method was identified as a good way to extract polysaccharides from Platycodon grandiflorum.
Article
Biochemistry & Molecular Biology
Xuyu Zhang, Zijing Liu, Cheng Zhong, Youwei Pu, Zhongwei Yang, Yixi Bao
Summary: This study aimed to investigate the structure, immune regulation, and anti-cancer abilities of polysaccharides in radix ginseng Rubra. Results showed that RGRP-1b has the potential to arrest the growth of Huh7 cells through immunoregulation while activating macrophages.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Geyi Zhang, Jinsheng Huang, Shuang Hao, Jingchao Zhang, Nan Zhou
Summary: A bioactive Radix Astragalus polysaccharide (RAP) extracted from traditional Chinese medicine (TCM) was found to promote nerve regeneration and angiogenesis, thereby enhancing functional recovery in peripheral nerve injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Quanwei Zhang, Lifeng Li, Shuang Hao, Man Liu, Chuying Huo, Jianjun Wu, Hongbing Liu, Wanrong Bao, Hongming Zheng, Zhipeng Li, Huiyuan Cheng, Hauyee Fung, Tinlong Wong, Pingchung Leung, Shunchun Wang, Ting Li, Ge Zhang, Min Li, Zhongzhen Zhao, Wei Jia, Zhaoxiang Bian, Timothy Mitchison, Jingchao Zhang, Aiping Lyu, Quanbin Han, Handong Sun
Summary: The gut barrier poses a significant research challenge in studying orally bioactive polysaccharides in both in vivo and in vitro studies, particularly in understanding how these polysaccharides interact with related cells in vivo. This study examines the antitumor activity of a hyperbranched heteroglycan RAP from Radix Astragali, showing that its activity is immune-dependent and that it enters Peyer's patches to target dendritic cells and initiate antitumor immune responses. These findings provide insights into a lymphatic route for orally administered RAP to directly interact with immune cells and trigger antitumor immune responses, bridging the gap between in vitro and in vivo studies.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Guangxin Li, Yanhong Ju, Yuwei Wen, Min Zuo, Chao Wang, Xiaomei Zhang, Xiaoxiang Hou, Guiqing Yang, Jianping Gao
Summary: This study divided Codonopsis radix polysaccharides into different molecular weight groups and evaluated their immunomodulatory effects. The results showed that polysaccharides with different molecular weights have different effects on immune response.
Article
Biochemistry & Molecular Biology
Wen-Na Zhang, Li-Li Gong, Zhong-Bo Zhou, Min Sun, Yuan-Yuan Li, Jing-Wen Sun, Yan Chen
Summary: In this study, a new polysaccharide fraction HLP-1 was extracted from the fruiting bodies of Helvella leucopus and its structure and functions were investigated. The results indicated that HLP-1 had the potential to enhance immunity and could be applied in functional foods.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Zhijun Xiao, Changyang Yan, Chunxue Jia, Ying Li, Yuanlin Li, Jie Li, Xinxin Yang, Xueyan Zhan, Changhua Ma
Summary: This study aims to extract and purify an active heteropolysaccharide called Chia seed polysaccharide (CSP-A), characterize its structure, and evaluate its antioxidant and immunomodulatory activities. The results showed that CSP-A had moderate antioxidant activity and immune regulation effect. This study provides scientific basis for further utilization and development of Chia seeds as a functional food.
Article
Biochemistry & Molecular Biology
Liuming Xie, Zhibing Huang, Hui Meng, Zhibing Fan, Xiaoyi Shi, Jianhua Xie
Summary: The addition of genistein during fermentation increased the yield of EPS produced by M. purpureus and improved its physicochemical properties, as well as enhanced its immunomodulatory activity. The genistein-treated M. purpureus EPS stimulated higher levels of nitric oxide and cytokine secretion in RAW264.7 macrophages, indicating its potential for improving the EPS yield of M. purpureus.
Article
Geriatrics & Gerontology
Di Zhao, Xiaojie Liu, Sijun Zhao, Zhenyu Li, Xuemei Qin
Summary: This study investigated the effects of d-gal on the gastrointestinal functions of aging rats, revealing significant impacts on small intestine propulsion rates, gastrointestinal transit time, and oxidative damages. Metabolomics analysis identified 40 metabolites involved in disruption of gastrointestinal functions, associated with pathways like amino acid metabolism and energy metabolism. This research provides insight into the mechanisms underlying d-gal-induced aging in rats and expands its applications in pharmacological research.
REJUVENATION RESEARCH
(2021)
Article
Cell Biology
Xiaojie Liu, Di Zhao, Sijun Zhao, Zhenyu Li, Yulan Wang, Xuemei Qin
Summary: This study explored the relationship between aging and constipation through behavioral analysis, fecal metabolomics, and network pharmacology. It found that aging and constipation are correlated, with some common metabolites and pathways involved. The results also provided support for the theoretical association between traditional Chinese medicine and Western medicine theories on aging and constipation.
Article
Biochemistry & Molecular Biology
Ji-Ning Chen, Xing-Kang Wu, Chun-Hua Lu, Xun Li
Summary: Through synthesizing and evaluating 42 novel acridone derivatives, it was found that the orientation and spatial topology of R-3 substituents play a significant role in bioactivity, exemplified by compounds E24, E25 and E27. These results provide valuable guidance for further development of acridone derivatives as potential drug candidates.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Plant Sciences
Xingkang Wu, Yufang Lu, Xuemei Qin
Summary: This study aimed to investigate the combined efficacy of Compound Kushen Injection (CKI)-derived combination strategies in p53-mutant CRC. The results showed that CKI combined with cisplatin (Cis) produced synergistic antitumor efficiency for p53-R273H/P309S mutant CRC cells. The combination of CKI and Cis reinforced cell death in a synergistic manner by inducing extrinsic apoptosis pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Xiaojie Liu, Xiaoling Wu, Di Zhao, Sijun Zhao, Zhenyu Li, Xuemei Qin
Summary: This study found a close relationship between gut microbiota and aging as well as constipation, possibly through metabolism. The composition of gut microbiome was similar in both aging and constipation, and key gut bacteria were clustered together. Gut microbial metabolites played important roles as signaling molecules in aging and constipation, and the occurrence and development of both conditions were influenced by multiple factors.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao Li, Ruihong Hou, Xuemei Qin, Yanfei Wu, Xingkang Wu, Junsheng Tian, Xiaoxia Gao, Guanhua Du, Yuzhi Zhou
Summary: This study demonstrates for the first time the synergistic neuroprotective effects of SSA and AF, and reveals the involved mechanisms of metabolic disorders regulation and neuroinflammation inhibition.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Shi-Fei Li, Xiu-Yi Wang, Gong-Lu Li, Ying-Ying Jiao, Wen-Hao Wang, Xing-Kang Wu, Li-Wei Zhang
Summary: This study isolated several new diterpenes from the leaves of Wikstroemia chamaedaphne and found that some of them have potential to reverse HIV latency. Furthermore, these compounds exert their effects by activating STAT1 activity.
Article
Geriatrics & Gerontology
Xiaojie Liu, Mengyu Li, Chen Jian, Fuxiao Wei, Huanle Liu, Ke Li, Xuemei Qin
Summary: This study investigates the effects of Astragalus polysaccharide (APS) on gastrointestinal functions and learning memory in elderly rats with constipation. The results show that APS significantly improves constipation and cognitive dysfunctions in rats, while also regulating gut microbiota and host metabolism.
REJUVENATION RESEARCH
(2022)
Article
Geriatrics & Gerontology
Xiaojie Liu, Ziyu Zhao, Yuhui Fan, Di Zhao, Yaze Wang, Meng Lv, Xuemei Qin
Summary: This study aims to reveal the possible correlations between depression and constipation from the perspectives of gut microbiome and plasma metabolome. Through constructing depressed and constipated rat models, locomotor activity and gastrointestinal functions were measured. Plasma metabolomics and gut microbiota sequencing were used to identify shared and unique metabolites between depression and constipation. The findings show that depression and constipation significantly affect locomotor activity, gastrointestinal functions, and gut microbiota compositions of rats, with perturbations in energy metabolism and amino acid metabolism.
Article
Chemistry, Multidisciplinary
Xingkang Wu, Lu Wang, Zhenyu Li
Summary: The transcription factor p53 plays a crucial role in regulating cellular responses to environmental changes. In this study, a compound called PQ1 was identified as a potential inhibitor of p53 transcriptional activity, with potential therapeutic applications and research value.
Article
Chemistry, Multidisciplinary
Kaiqing Ma, He Yang, Xingkang Wu, Fangjun Huo, Fangqin Cheng, Caixia Yin
Summary: A new liposoluble cationic probe, KC8, was developed to detect NAD(P)H and monitor the abnormality of p53 in colorectal cancer cells in real time.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Shifei Li, Xiuyi Wang, Yuqin Yang, Xingkang Wu, Liwei Zhang
Summary: Four sesquiterpenes, five flavonoids, and two lignans were isolated from the roots of Wikstroemia chamaedaphne. Among them, oleodaphnone (2) exhibited effective activation of latent HIV, with time- and concentration-dependent effects. Transcriptome analysis revealed that oleodaphnone regulated multiple signaling pathways, providing a potential basis for its development as an HIV latency-reversing agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Xiaojie Liu, Xiaoling Wu, Senyan Wang, Xuemei Qin
Summary: This study aimed to reveal the compatibility of Xiaoyaosan (XYS) in anti-depression through the perspective of the gut-liver-kidney axis. Results showed that XYS and its efficacy groups significantly regulated the abnormalities of behaviors, kidney metabolism, and intestinal disorders in depressed rats. XYS exhibited the strongest regulation, followed by the Shugan (SG) and Jianpi (JP) groups. The findings provide innovative insights into the anti-depression effects and compatibility of XYS, as well as a new perspective and methodology for studying complex diseases and traditional Chinese medicine (TCM) compatibility.
Review
Biochemistry & Molecular Biology
Xingkang Wu, Yushuang Ma, Lu Wang, Xuemei Qin
Summary: This article reviews the common pathological mechanisms between psoriasis and cancer, including the interaction between cell proliferation and an abnormal immune microenvironment, metabolic reprogramming, and epigenetic reprogramming. The article also discusses the shared therapeutic agents and drug targets between psoriasis and cancer. The author suggests that investigating psoriasis from a cancer perspective can enrich research strategies related to psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiaojie Liu, Chen Jian, Mengyu Li, Fuxiao Wei, Huanle Liu, Xuemei Qin
Summary: This study investigated the impact of constipation in an aged rat model and the effects of Cistanche deserticola polysaccharide (CDPS) on constipation. The study found that CDPS significantly regulated behavioral indexes, gut microbiota, and fecal metabolites in constipated rats. It increased beneficial bacteria and decreased potentially pathogenic bacteria. 16 potential biomarkers of constipation in aged rats were identified. The findings deepen our understanding of constipation in the elderly and provide a foundation for using polysaccharides to treat constipation and improve the quality of life of the elderly.