Article
Medicine, General & Internal
D. Herbert Opi, Michelle J. Boyle, Alistair R. D. McLean, Linda Reiling, Jo-Anne Chan, Danielle Stanisic, Alice Ura, Ivo Mueller, Freya J. Fowkes, Stephen J. Rogerson, James G. Beeson
Summary: The study identified pregnant women who developed antibodies that effectively promoted complement fixation on placental-binding pRBCs, associated with protection against MiP. These complement-fixing antibodies primarily targeted a specific variant of PfEMP1 called VAR2CSA, and complement enhanced the ability of antibodies to inhibit pRBC binding to CSA for increased protection.
Article
Physiology
Evangeline Deer, Kristin E. Reeve, Lorena Amaral, Venkata Ramana Vaka, Michael Franks, Nathan Campbell, Sarah Fitzgerald, Owen Herrock, Tarek Ibrahim, Denise Cornelius, Babbette LaMarca
Summary: This study demonstrated that CD4+ T cells, independent of NK cells, cause mitochondrial dysfunction/ROS, contributing to hypertension in response to placental ischemia during pregnancy.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thijs W. de Vos, Dian Winkelhorst, Hans J. Baelde, Kyra L. Dijkstra, Rianne D. M. van Bergen, Lotte E. van der Meeren, Peter G. J. Nikkels, Leendert Porcelijn, C. Ellen van der Schoot, Gestur Vidarsson, Michael Eikmans, Rick Kapur, Carin van der Keur, Leendert A. Trouw, Dick Oepkes, Enrico Lopriore, Marie-Louise P. van der Hoorn, Manon Bos, Masja de Haas
Summary: This study found that untreated FNAIT cases showed more C4d deposition in the placenta, which may impact placental function and fetal growth. Histopathological examination revealed a certain proportion of placental delayed maturation in these cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Anthony M. Carter
Summary: The hormones secreted by the placenta have effects on maternal physiology, but their specific functions are not yet fully understood. Different species have evolved their own sets of placental hormones, some of which show convergent evolution and overlapping functions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Jake R. Thomas, Praveena Naidu, Anna Appios, Naomi McGovern
Summary: The placenta, essential for maternal and fetal health, contains fetal macrophages and syncytial cells. Recent research has led to new understanding of the origin, phenotype, and function of placental macrophages. The application of new technologies in placental research is aiding in further understanding these cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Junya Kojima, Masanori Ono, Naoaki Kuji, Hirotaka Nishi
Summary: The placenta is crucial for establishing pregnancy and fetal well-being in humans, allowing for maternal physiological adaptation and embryonic immunological acceptance. Placental tissue varies widely among species, making it challenging to directly apply findings from animal studies to human research. Artificial induction of early villous differentiation can potentially elucidate the causes of perinatal diseases and aid in the development of novel therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Lunbo Tan, Zhilong Chen, Fen Sun, Zhuoqun Zhou, Baozhen Zhang, Baobei Wang, Jie Chen, Mengxia Li, Tianxia Xiao, Rugina Neuman, Jianmin Niu, Koen Verdonk, Xifeng Lu, Jian Zhang, A. H. Jan Danser, Qing Yang, Xiujun Fan
Summary: Maternal circulating levels of the adipokine chemerin are elevated in preeclampsia. Placental chemerin overexpression disturbs normal placental development, leading to fetal growth restriction/resorption and the development of preeclampsia. Chemerin might be a novel biomarker of preeclampsia, and inhibition of the chemerin/CMKLR1 pathway is a promising novel therapeutic strategy to treat preeclampsia.
Review
Pharmacology & Pharmacy
Silvia Cavalli, Paola Adele Lonati, Maria Gerosa, Roberto Caporali, Rolando Cimaz, Cecilia Beatrice Chighizola
Summary: The complement system has a significant role in various rheumatologic conditions, including rheumatoid arthritis, psoriatic arthritis, Sjogren syndrome, systemic sclerosis, vasculitides, and dermatomyositis. Complement deposition is associated with disease severity, and serum complement levels may serve as potential markers for evaluating disease activity. In pregnancy, the complement system also plays a crucial role, and alterations in complement levels may be associated with pregnancy complications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Developmental Biology
Chie-Pein Chen, Liang-Kai Wang, Chen-Yu Chen, Chia-Yu Chen, Yi-Hsin Wu
Summary: The study found that Slit2 expressed by human placental mesenchymal stromal cells may modulate the activity and migration of inflammatory macrophages in the placenta, potentially representing a novel mechanism for LPS-induced placental infection.
MOLECULAR HUMAN REPRODUCTION
(2021)
Review
Medicine, Research & Experimental
Yang Liu, Jing Cao, Xingli Gao, Songwei Gao, Yu Song, Yongran Guo
Summary: Pregnancy complications have a significant impact on millions of women each year, but there is currently no safe and effective treatment available. Placenta-specific therapy, which targets abnormal placental development using biomolecules and signaling pathways, shows promise as a safe and effective therapeutic strategy. This review provides a detailed explanation of the physiological structure and characteristics of the placenta, as well as the mechanisms of biomolecules and signaling pathways involved in normal and abnormal placental development. It also discusses how these biomolecules can be used as therapeutic targets and explores the potential of nanodelivery systems in placenta-specific therapy.
MOLECULAR PHARMACEUTICS
(2022)
Article
Endocrinology & Metabolism
Katrien Benhalima, Diane D. Ma, Annouschka Laenen, Chantal Mathieu, Jose A. Halperin
Summary: The study found that women with higher postpartum plasma glycated CD59 (pGCD59) levels were more likely to develop glucose intolerance, with a 0.5-unit increase in pGCD59 associated with a 3.3-fold increase in risk of glucose intolerance postpartum. pGCD59 measured during pregnancy was a poor predictor for glucose intolerance postpartum.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Olaf Uhl, Rohan M. Lewis, Birgit Hirschmugl, Sarah Crozier, Hazel Inskip, Antonio Gazquez, Nicholas C. Harvey, Cyrus Cooper, Gernot Desoye, Berthold Koletzko, Christian Wadsack, Hans Demmelmair, Keith M. Godfrey
Summary: The study found specific differences in polar-lipid composition and related gene expression in placentas of different sizes. These differences in lipid composition were associated with birth weight and neonatal lean mass, indicating that placental lipid composition may influence prenatal lean mass accretion.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Immunology
Yash Pandya, Alexander Marta, Andre Barateiro, Carla Leticia Bandeira, Jamille Gregorio Dombrowski, Joao Costa, Claudio Romero Farias Marinho, Carlos Penha-Goncalves
Summary: Pregnancy-associated malaria may affect placental endothelin gene expression and endothelin receptor B protein levels by interfering with maternal and fetal TLR4 alleles. Fetal protection during Plasmodium infection is mediated by fetal TLR4 signaling, which controls trophoblast motility and vasoregulatory responses in the placenta. These findings highlight the importance of fetal innate immune sensing in protecting against adverse pregnancy outcomes associated with malaria.
INFECTION AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Lisa Hui, Natalie J. Hannan
Summary: Elevated levels of OLAH in the placenta may be associated with placental dysfunction in pregnancies complicated by preterm preeclampsia and fetal growth restriction. Further research is required to understand the role of OLAH in the placenta, and whether these changes are a maternal adaptation or consequence of disease.
Article
Biochemistry & Molecular Biology
Edgar Ontsouka, Alessandra Epstein, Sampada Kallol, Jonas Zaugg, Marc Baumann, Henning Schneider, Christiane Albrecht
Summary: The study found significant alterations in placental SLCO3A1 (OATP3A1) gene expression in patients with intrahepatic cholestasis of pregnancy (ICP), while the expression levels of the other 20 genes were comparable between healthy and ICP placentae. Additionally, certain genes in ICP placentae showed positive correlations with BA concentrations and maternal body mass index.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Arin N. Graner, Justin E. Hellwinkel, Alex M. Lencioni, Helen J. Madsen, Tessa A. Harland, Paul Marchando, Ger J. Nguyen, Mary Wang, Laura M. Russell, Lynne T. Bemis, Thomas J. Anchordoquy, Michael W. Graner
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2017)
Article
Biochemistry & Molecular Biology
Jean F. Regal, Megan E. Strehlke, Jenna M. Peterson, Cameron R. Wing, Jordan E. Parker, Noel Fernando Nieto, Lynne T. Bemis, Jeffrey S. Gilbert, Sherry D. Fleming
MOLECULAR IMMUNOLOGY
(2016)
Article
Oncology
Kun Zhou, Kevin W. Diebel, Jon Holy, Andrew Skildum, Evan Odean, Douglas A. Hicks, Brent Schotl, Juan E. Abrahante, Monique A. Spillman, Lynne T. Bemis
Article
Microbiology
Dylan W. White, Sarah R. Elliott, Evan Odean, Lynne T. Bemis, Anna D. Tischler
Article
Behavioral Sciences
B. Vestal, P. Russell, R. A. Radcliffe, L. Bemis, L. M. Saba, K. Kechris
BRAIN AND BEHAVIOR
(2018)
Article
Cardiac & Cardiovascular Systems
Connor F. Laule, Evan J. Odean, Cameron R. Wing, Kate M. Root, Kendra J. Towner, Cassandra M. Hamm, Jeffrey S. Gilbert, Sherry D. Fleming, Jean F. Regal
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2019)
Article
Oncology
Eric Jeffords, Samuel Freeman, Breanna Cole, Kate Root, Thierry Chekouo, Richard G. Melvin, Lynne Bemis, Glenn E. Simmons
Article
Microbiology
Marna E. Ericson, Edward B. Breitschwerdt, Paul Reicherter, Cole Maxwell, Ricardo G. Maggi, Richard G. Melvin, Azar H. Maluki, Julie M. Bradley, Jennifer C. Miller, Glenn E. Simmons, Jamie Dencklau, Keaton Joppru, Jack Peterson, Will Bae, Janet Scanlon, Lynne T. Bemis
Summary: This study found evidence of Bartonella spp. exposure/infection in a small number of melanoma patients, with Bartonella organisms co-localizing with VEGFC immunoreactivity in tissues. Further investigations are needed to determine the extent to which Bartonella spp. are involved in the pathobiome of melanoma.
Article
Microbiology
Emily N. Hendrickson, Marna E. Ericson, Lynne T. Bemis
Summary: The COVID-19 pandemic has highlighted the importance of understanding the mechanisms of host-pathogen interactions during viral infection. This study identified and confirmed the binding of transfer RNA-derived RNAs (tDRs) to specific regions of the SARS-CoV-2 genome, providing evidence for a novel mechanism of host-pathogen regulation.
Article
Medicine, General & Internal
Azar Maluki, Edward Breitschwerdt, Lynne Bemis, Rosalie Greenberg, Bobak Robert Mozayeni, Jamie Dencklau, Marna Ericson
CLINICAL CASE REPORTS
(2020)
Review
Peripheral Vascular Disease
Jean F. Regal, Richard M. Burwick, Sherry D. Fleming
CURRENT HYPERTENSION REPORTS
(2017)
Article
Biochemical Research Methods
Kun Zhou, Monique A. Spillman, Kian Behbakht, Julia M. Komatsu, Juan E. Abrahante, Douglas Hicks, Brent Schotl, Evan Odean, Kenneth L. Jones, Michael W. Graner, Lynne T. Bemis
ANALYTICAL BIOCHEMISTRY
(2017)
Article
Physiology
Jean F. Regal, Connor F. Laule, Luke McCutcheon, Kate M. Root, Hayley Lund, Shireen Hashmat, David L. Mattson
PHYSIOLOGICAL REPORTS
(2018)