Article
Cell Biology
Melissa R. Bentley-Ford, Reagan S. Andersen, Mandy J. Croyle, Courtney J. Haycraft, Kelsey R. Clearman, Jeremy B. Foote, Jeremy F. Reiter, Bradley K. Yoder
Summary: Atxn10 gene is involved in cytokinesis and is associated with spinocerebellar ataxia, nephronophthisis, and Joubert syndrome. Disruption of Atxn10 leads to embryonic lethality in mice and severe pancreatic and renal abnormalities in adult mice, causing death within a few weeks post Atxn10 deletion. This study reveals that Atxn10 is essential for survival and its loss results in rapid epithelial-to-mesenchymal transition in tissues like the pancreas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Qiao Ping Xu, Kui Deng, Zhen Zhang, Hongkai Shang
Summary: Ovarian cancer is a growing global disease, and there is an urgent need for chemotherapy and targeted therapy. SLFN5 plays an important role in malignancy, but its specific function in ovarian cancer cells is still unclear. This study suggests that SLFN5 expression is related to the progression and malignancy of ovarian cancer, and its silencing has a significant inhibitory effect on the invasion and metastasis ability of ovarian cancer cells. Therefore, SLFN5 may serve as a potential target for future drug development in the treatment of ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Kamen P. Simeonov, China N. Byrns, Megan L. Clark, Robert J. Norgard, Beth Martin, Ben Z. Stanger, Jay Shendure, Aaron McKenna, Christopher J. Lengner
Summary: This study introduces a new inducible CRISPR-Cas9-based lineage recorder, macsGESTALT, and reveals that the metastatic potential of cells peaks in rare, late-hybrid EMT states, which are relevant to clinical disease progression.
Article
Cell Biology
William L. Harryman, Kendra D. Marr, Ray B. Nagle, Anne E. Cress
Summary: This article discusses the diffusion and invasion mechanisms of muscle-invasive cancers in specialized biophysical and growth factor enriched microenvironments. The study proposes that the heterogeneity of cell-cell and cell-ECM adhesion receptors is a key factor in driving aggressive tumor networks, while the tumor's phenotype heterogeneity allows it to traverse through muscle and survive. The study also identifies the existence of epithelial-mesenchymal cooperation (EMC) within the tumor invasive network, facilitating tumor escape, muscle invasion, and metastasis. Additionally, the study highlights the special characteristics of the smooth muscle microenvironment and its alteration by primary tumors that contribute to tumor escape.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Yih-Shou Hsieh, Shu-Chen Chu, Shih-Chien Huang, Shao-Hsuan Kao, Meng-Shuan Lin, Pei-Ni Chen
Summary: The research showed that gossypol inhibited the invasion and migration of human cervical cancer cells by targeting the FAK signaling pathway and reversing TGF-beta 1-induced EMT.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Aitao Sun, JinBo Li, Weijing Kong, Xiaodong Jiang
Summary: This study investigates the expression and underlying mechanisms of the immunoglobulin superfamily containing leucine-rich repeat (ISLR) in gastric cancer (GC). The findings suggest that ISLR is overexpressed in GC tumor tissues and cells and is associated with lymph node metastasis, tumor size, and clinical stage. Additionally, ISLR regulates the epithelial-mesenchymal transition (EMT) signaling pathway and affects cell viability, proliferation, migration, and invasion in GC cells. These results provide new evidence for the role of ISLR in GC progression.
Article
Biochemistry & Molecular Biology
Qiaosi Tang, Ashley Lento, Kensuke Suzuki, Gizem Efe, Tatiana Karakasheva, Apple Long, Veronique Giroux, Mirazul Islam, E. Paul Wileyto, Andres J. Klein-Szanto, Hiroshi Nakagawa, Adam Bass, Anil K. Rustgi
Summary: The study reveals that TP53 mutation is the most common in ESCC, while Rab11-FIP1 gene is significantly downregulated in mutant p53 tumor cells. Genetic knockdown of Rab11-FIP1 results in increased organoid size and promotes tumor cell invasion through mutant p53.
Review
Biochemistry & Molecular Biology
Andrea Abaurrea, Angela M. Araujo, Maria M. Caffarel
Summary: Epithelial-mesenchymal plasticity (EMP) is crucial in cancer development, promoting the acquisition of mesenchymal features in cancer cells through cytokine signal transduction pathways, such as the interleukin 6 (IL-6) family. However, the effect may depend heavily on the context.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Mei-Tsz Su, Pei-Yin Tsai, Chia-Yih Wang, Hui-Ling Tsai, Pao-Lin Kuo
Summary: Preeclampsia is a severe gestational hypertensive disorder that poses a major threat to maternal and fetal health. Aspirin has been shown to effectively reduce the incidence of premature preeclampsia among high-risk pregnant women, possibly by suppressing miR-200 family-mediated cell functions. This study demonstrates a potential mechanism explaining aspirin's effect on preeclampsia prevention and provides a therapeutic target for disease intervention.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Samuel A. Vilchez Mercedes, Federico Bocci, Mona Ahmed, Ian Eder, Ninghao Zhu, Herbert Levine, Jose N. Onuchic, Mohit Kumar Jolly, Pak Kin Wong
Summary: In this study, the researchers used a combination of immunocytochemistry, single cell biosensors, and computational modeling to show that the transcription factor Nrf2 functions as a phenotypic stability factor for hybrid epithelial/mesenchymal cells during collective cancer migration. They also demonstrated that Nrf2 and EMT signaling are spatially coordinated near the leading edge, and that the Nrf2-EMT-Notch network enhances the expression of certain genes associated with the formation of leader cells and protruding tips.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Claudia M. Garcia-Cuellar, Miguel Santibanez-Andrade, Yolanda I. Chirino, Raul Quintana-Belmares, Rocio Morales-Barcenas, Ericka Marel Quezada-Maldonado, Yesennia Sanchez-Perez
Summary: The study demonstrated that PM10 exposure induces EMT in lung cancer cells, leading to an increase in invasive phenotype. TGFB1 plays a crucial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Priyanka Chakraborty, Emily L. Chen, Isabelle McMullen, Andrew J. Armstrong, Mohit Kumar Jolly, Jason A. Somarelli
Summary: Epithelial-mesenchymal plasticity is crucial in solid tumors for metastasis and treatment resistance, and is also linked to immune evasion. The immunological features of different tumor types can be characterized by gene expression datasets, with specific immune subtypes associated with EMT scores and immune checkpoint marker expression.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Oncology
Minal Garg
Summary: There is a strong association between cancer incidence and mortality, emphasizing the importance of understanding the mechanisms that drive tumor cells to rapidly progress and become resistant to therapy. Epithelial-mesenchymal plasticity (EMP) has emerged as a key regulator of metastatic outgrowth, allowing tumor cells to delaminate from their neighbors, traverse barriers, and establish distal metastases. The presence of dynamic intermediate states and the existence of hybrid epithelial/mesenchymal (E/M) phenotypes are increasingly reported in various tumor contexts.
CANCER AND METASTASIS REVIEWS
(2022)
Article
Multidisciplinary Sciences
Thimios A. Mitsiadis, Lucia -Rojo, Anamaria Balic, Silvio Weber, Paul Saftig, Pierfrancesco Pagella
Summary: The Adam10/Notch axis controls dental epithelial cell boundaries, cell fate switch, and proper enamel formation in continuously growing incisors.
Article
Oncology
Yun-Ju Lai, Chi-Hong Chao, Chun-Che Liao, Te-An Lee, Jung-Mao Hsu, Wen-Cheng Chou, Jyun Wang, Hsiang-Chi Huang, Shing-Jyh Chang, Yi-Ling Lin, Chia-Wei Li
Summary: The engagement of hACE2 and SARS-CoV-2 spike protein promotes virus spread, while inducing EMT phenotypic changes and stemness in breast cancer cells through Snail modulation. The spike protein S of SARS-CoV-2 is crucial in inducing EMT marker changes, and Snail upregulation is essential for the virus-mediated aggressive phenotype in cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Pathology
Kathleen R. Mulka, Sarah E. Beck, Clarisse Solis, Andrew L. Johanson, Suzanne E. Queen, Megan E. McCarron, Morgan R. Richardson, Ruifeng Zhou, Paula Marinho, Anne Jedlicka, Selena Guerrero-Martin, Erin N. Shirk, Alicia M. Braxton, Jacqueline Brockhurst, Patrick S. Creisher, Santosh Dhakal, Cory F. Brayton, Rebecca T. Veenhuis, Kelly A. Metcalf Pate, Petros C. Karakousis, Cynthia A. Zahnow, Sabra L. Klein, Sanjay K. Jain, Patrick M. Tarwater, Andrew S. Pekosz, Jason S. Villano, Joseph L. Mankowski
Summary: The progression of SARS-CoV-2 in a Syrian hamster model provides valuable insights for the development of therapeutic and preventive interventions for COVID-19.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Gastroenterology & Hepatology
Min Kyu Sung, Hosub Park, Guisuk Park, Seo Young Park, Woohyung Lee, Ki Byung Song, Jae Hoon Lee, Song Cheol Kim, Dae Wook Hwang, Seung Mo Hong
Summary: This study investigated the prognostic implications of extranodal extension (ENE) in patients with surgically resected pancreatic cancer. The results showed that patients with ENE had lower disease-free survival rates, especially those with nodal metastasis. Therefore, ENE should be considered a prognostic factor in the staging system of pancreatic cancer.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Biochemical Research Methods
Ashley L. Kiemen, Alicia M. Braxton, Mia P. Grahn, Kyu Sang Han, Jaanvi Mahesh Babu, Rebecca Reichel, Ann C. Jiang, Bridgette Kim, Jocelyn Hsu, Falone Amoa, Sashank Reddy, Seung-Mo Hong, Toby C. Cornish, Elizabeth D. Thompson, Peng Huang, Laura D. Wood, Ralph H. Hruban, Denis Wirtz, Pei-Hsun Wu
Summary: This study introduces a method called CODA for reconstructing three-dimensional microanatomical structures in large tissues using serially sectioned stained sections. The researchers demonstrated the effectiveness of CODA in reconstructing structures in pancreas, skin, lung, and liver tissues. They also applied CODA to analyze the microanatomy of the human pancreas during tumorigenesis.
Article
Oncology
Yasuhiro Sakai, Kazuya Yoshinaga, Ayaka Yoshida, Andri Rezano, Kazuya Shiogama, Yoshiaki Kawashima, Tadashi Yoshizawa, Akihiko Yoshizawa, Shingo Hatakeyama, Chikara Ohyama, Hiroyasu Ito, Masato Abe, Hiroshi Kijima, Yoshiro Otsuki, Akihiko Ito, Toyonori Tsuzuki, Motohiro Takeya, Nobuo Sakaguchi, Kazuhiko Kuwahara
Summary: This study reveals that the overexpression of GANP is an essential factor in the development of testicular teratomas and establishes a novel mouse model to investigate the underlying mechanisms.
Article
Gastroenterology & Hepatology
Yuri Kim, Bokyung Ahn, Kee Don Choi, Beom-Su Kim, Jeong-Hwan Yook, Gin Hyug Lee, Seung-Mo Hong, Jeong Hoon Lee
Summary: This study systematically evaluated the clinical and pathologic characteristics of gastric neuroendocrine tumors (NETs) based on the 2019 WHO classification. The results showed that grade 2 and grade 3 gastric NETs are associated with larger size, deeper invasion, and extragastric recurrence, requiring active treatment.
Letter
Cell Biology
Ashley L. Kiemen, YoungGeun Choi, Alicia M. Braxton, Cristina Almagro Perez, Sarah Graham, Mia P. Grahn, Neha Nanda, Nicholas Roberts, Laura Wood, PeiHsun Wu, Ralph H. Hruban, Denis Wirtz
Article
Pathology
Shintaro Goto, Atsuko Nakazawa, Tadashi Yoshizawa, Masahiko Aoki, Takeshi Hirabayashi, Hiroko Seino, Satoko Morohashi, Hiroshi Kijima
Summary: Epignathus is an extremely rare teratoma found in the oral cavity or oropharyngeal region of newborns. This study describes a case of giant epignathus arising from the oropharynx in a newborn, which completely obstructed the airway and resulted in death. Histological and radiological examination revealed a well-developed skeleton of the head and neck, along with teeth, spinal bones, glands, trachea, and cerebral tissue within the tumor. These findings suggest that the epignathus is a fetus-in-fetu, classified as a type 0 germ cell tumor according to current literature.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Keisuke Yamazaki, Taiichi Wakiya, Keinosuke Ishido, Norihisa Kimura, Daichi Ichinohe, Yoshiya Takahashi, Tadashi Yoshizawa, Hiroshi Kijima, Kenichi Hakamada
Summary: This article reports a case of serous cystic neoplasm (SCN) with jejunal invasion. Based on the case, the authors suggest monitoring and surgical resection decisions based on tumor size and growth rate to avoid malignant transformation and provide organ-sparing, less invasive surgery for patients.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2023)
Letter
Clinical Neurology
Yasuo Miki, Eri Shibuya, Tadashi Yoshizawa, Masahiko Tomiyama, Koichi Wakabayashi
NEUROLOGICAL SCIENCES
(2023)
Article
Oncology
Shintaro Goto, Tadashi Yoshizawa, Keinosuke Ishido, Hiroko Seino, Satoko Morohashi, Hirokazu Ogasawara, Shunsuke Kubota, Kenta Ogasawara, Akie Nakamura, Kenichi Hakamada, Hiroshi Kijima
Summary: The aim of this study was to investigate the histological changes caused by neoadjuvant chemotherapy (NAC) for pancreatic ductal adenocarcinoma (PDAC) and evaluate the use of time-density curves (TDCs) of dynamic contrast-enhanced computed tomography (CECT) for determining the histological therapeutic effects of NAC for PDAC. The results showed that NAC led to a decrease in cancer cells and cancer-associated fibroblasts (CAFs) and an increase in stromal collagen fibers. Radiological analysis revealed that certain slopes of the TDCs were significantly different between high-responders and low-responders. Receiver operating characteristic curve analysis showed that certain changes in the TDCs were effective indicators of the histological therapeutic effect of NAC. In conclusion, TDCs of dynamic CECT may be a useful tool for determining the histological therapeutic effect of NAC for PDAC.
Article
Oncology
Takafumi Yachi, Tadashi Yoshizawa, Norihisa Kimura, Hiroko Seino, Satoko Morohashi, Shintaro Goto, Keinosuke Ishido, Hiroshi Kijima, Kenichi Hakamada
Summary: Malignant tumors in cholangiocarcinoma are diagnosed and staged using FDG-PET and clinical analysis, but comprehensive analysis, including pathological analysis, has not been sufficiently performed. This study calculated SUVmax using FDG-PET and analyzed its relationship with clinicopathological factors. The results showed that the SUV-high group had a higher postoperative recurrence rate, as well as higher Glut1 and Ki-67 expression rates. Furthermore, there was a positive correlation between SUVmax and Glut1 expression, as well as SUVmax and Ki-67 expression rates. Thus, the preoperative measurement of SUVmax by PET-CT is useful in predicting recurrence and cancer malignancy.
Review
Medicine, Research & Experimental
Ashley L. Kiemen, Alexander Ioannis Damanakis, Alicia M. Braxton, Jin He, Daniel Laheru, Elliot K. Fishman, Patrick Chames, Cristina Almagro Perez, Pei-Hsun Wu, Denis Wirtz, Laura D. Wood, Ralph H. Hruban
Summary: Pancreatic cancer is the third leading cause of cancer death in the United States, with clinical characteristics including abdominal pain, imaging features, and liver metastases. Tissue clearing and 3D reconstruction techniques have provided insights into the clinical features of this disease at a cellular level.
Article
Pathology
Jihyun Chun, Yeon Wook Kim, Seo-rin Jeong, Hyung Jun Cho, Kyu-Pyo Kim, Dae Wook Hwang, Seung-Mo Hong
Summary: Although nodal metastasis is an important prognostic factor in ampullary adenocarcinoma, the prognostic significance of extranodal extension (ENE) is not well defined. This study investigated the presence of nodal metastasis with ENE in 279 surgically resected patients and compared it with other clinicopathological factors, including overall survival and recurrence-free survival. The results showed that ENE was associated with poorly differentiated tumors and had worse overall survival and recurrence-free survival rates. Evaluation of ENE can provide additional survival information for patients with surgically resected ampullary carcinoma.
Review
Pathology
Paola Mattiolo, Huamin Wang, Olca Basturk, Lodewijk A. A. Brosens, Seung-Mo Hong, Volkan Adsay, Aldo Scarpa, Claudio Luchini
Summary: This study aimed to conduct a systematic review on acinar cystic transformation (ACT) of the pancreas. The findings showed that ACT is a benign entity and does not require surgical resection except for symptomatic cases. Intracystic pancreatic intraepithelial neoplasia (PanIN) and driver mutations were rare, suggesting the need for preoperative diagnosis and long-term follow-up of ACT.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Medicine, General & Internal
Sang-Woo Ha, Shin Hwang, Hyejin Han, Song Ie Han, Seung-Mo Hong
Summary: This case report presents a patient with mucinous cystic neoplasm of the liver who had a successful outcome after surgical resection.
JOURNAL OF YEUNGNAM MEDICAL SCIENCE
(2022)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.