Article
Veterinary Sciences
Piyanan Taweethavonsawat, Kasem Rattanapinyopituk, Kittipong Tachampa, Srireepong Kiertkrittikhoon, Wanarit Jitsamai, Wuthichai Klomkleaw, Nan Choisunirachon, Kiatpichet Komin
Summary: This case report describes a 9-year-old spayed female boxer with heartworm infection and hindlimb lameness, accompanied by a penetrating parasitic worm coming out of a wound. The postmortem examination suggested that the dog died due to severe tissue damage and complications caused by the extensive heartworm infection.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Editorial Material
Infectious Diseases
Kamal Makhoul, Yousef Shukha, Lana Abu Hanna, Samy Nitecki, Maxim Leiderman, Tony Hayek, Shadi Hamoud
Summary: COVID-19 is a disease with multisystemic involvement, caution should be taken with the complications that may lead to arterial and venous thromboembolic events, even resulting in amputation of the affected limbs.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Cell & Tissue Engineering
Hao Liu, Yuan Fang, Tianyue Pan, Gang Fang, Yifan Liu, Xiaolang Jiang, Bin Chen, Shiyang Gu, Zheng Wei, Peng Liu, Weiguo Fu, Jue Yang, Zhihui Dong
Summary: This study investigated the recurrence conditions of a relatively large cohort of patients with angiitis-induced critical limb ischemia (AICLI). The results showed that patients with AICLI who underwent cell transplantation had a higher risk of recurrence if multiple limbs were involved and if the period of ischemia relief was longer.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Meixin Zhang, Yixi Chen, Yumin Qiu, Jiapan Sun, Jiang He, Zhefu Liu, Jian Shi, Wenbin Wei, Guifu Wu, Jianwen Liang
Summary: This study found that PCSK9 aggravates cell death in vascular endothelial cells by regulating Smac translocation, thereby affecting the formation of ischemic lesions. Overexpression of PCSK9 impairs angiogenesis and reduces blood perfusion, while inhibiting PCSK9 can reverse these effects. This provides new theoretical support for targeting PCSK9 as a potential treatment for critical limb ischemia.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Mohamed S. El Masry, Surya C. Gnyawali, Chandan K. Sen
Summary: This study aimed to develop a robust and clinically relevant swine model of critical limb ischemia (CLI) involving the onset of ischemic muscle necrosis. The researchers successfully induced severe ischemia and validated its success using various imaging and pathological techniques. The developed model allows for long-term survival studies and compliance with animal welfare regulations.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
Elizabeth A. Andraska, Amanda R. Phillips, Katherine M. Reitz, Sina Asaadi, Jonathan Ho, Mackenzie M. McDonald, Michael Madigan, Nathan Liang, Mohammad Eslami, Natalie Sridharan
Summary: This study found that younger age was associated with worse short-term limb-related outcomes in patients with ALI due to de novo thrombosis or embolus. Younger patients were more likely to have embolism from a proximal arterial source, while older patients were more often from a cardiac source.
JOURNAL OF VASCULAR SURGERY
(2022)
Review
Cell & Tissue Engineering
Zeinab Shirbaghaee, Mohammad Hassani, Saeed Heidari Keshel, Masoud Soleimani
Summary: This article reviews the immunomodulatory features of mesenchymal stem cells (MSCs) and their potential applications as therapeutic agents in the treatment of critical limb ischemia (CLI). Despite advances in clinical research, MSC therapy is still considered experimental and not recommended for regular clinical use. The article provides recommendations to improve the efficacy of cell therapy for CLI patients.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Engineering, Biomedical
Zheng Xing, Chen Zhao, Siwen Wu, Chunchen Zhang, Haifeng Liu, Yubo Fan
Summary: Therapeutic angiogenesis provides a potential solution for critical limb ischemia by manipulating blood vessel growth in vivo without the need for extra pharmaceutics and surgery. With the rise of interdisciplinary research, regenerative medicine strategies offer new possibilities for treating various clinical diseases.
Article
Surgery
Robert Myers, Bakhtawar Mushtaq, Nicholas Taylor, Hajar Rashid, Danielle M. Pineda
Summary: This study aims to understand the impact of bypass surgery on limb salvage in patients aged >80 years with critical limb ischemia. The study found that there was no significant difference in limb salvage, hospital length of stay, and primary patency between patients aged <80 years and those aged >=80 years. However, further studies are needed to determine the statistical impact on mortality in this population with a larger cohort.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Multidisciplinary Sciences
Yuya Ota, Yasue Kubota, Yuji Hotta, Mami Matsumoto, Nayuka Matsuyama, Taiki Kato, Takashi Hamakawa, Tomoya Kataoka, Kazunori Kimura, Kazunobu Sawamoto, Takahiro Yasui
Summary: The photochemically-induced thrombosis method was used to establish a new rat model of urinary frequency with focal cerebral infarction. The model showed nonlethality, high reproducibility, and changes in micturition intervals post-stroke. Overall, this novel model may be suitable for studying urinary frequency after focal cerebral infarction.
Article
Physiology
Huiyin Tu, Junliang Qian, Dongze Zhang, Aaron N. Barksdale, Michael C. Wadman, Iraklis I. Pipinos, Yu-Long Li
Summary: The study found that BALB/c mice showed more severe skeletal muscle changes, including muscle fiber atrophy, accumulation of adipose-like tissue, and fibrosis, compared to C57BL/6 mice after femoral artery ligation. Furthermore, BALB/c mice exhibited greater damage in neuromuscular junctions and muscle contraction responses to ischemia, suggesting potential differences in the strain-specific responses to PAD.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Aamal G. El-Waseif, Manar A. Nader, Hatem A. Salem, Sally L. Elshaer
Summary: The study demonstrates that the ROCK inhibitor Fasudil provides vascular protection in an experimentally induced unilateral critical limb ischemia (CLI) model in mice, possibly by restoring antioxidant capacity and inhibiting inflammatory response.
Article
Neurosciences
Lipo Xiao, Xunming Ji, Haiping Zhao, Yumin Luo, Shuyuan Hu, Tingyu Zhao, Zeliang Hu, Jiangang Duan
Summary: The study established a novel severe CVST model using semi-ligation, ferric chloride, and thrombin. Compared with the non-semi-ligation group, the semi-ligation group showed more severe short-term and long-term neurological dysfunction, higher thrombus weight and venous infarction volumes, and increased microglia activation.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Lucia Beltran-Camacho, Marta Rojas-Torres, Ma Carmen Duran-Ruiz
Summary: Critical limb ischemia is the most severe form of peripheral arterial disease, commonly caused by atherosclerosis leading to progressive blockage of arterial vessels. For patients not suitable for surgical intervention, angiogenic cell therapy has emerged as a promising alternative, showing potential for enhancing revascularization by promoting vessel formation and blood flow recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Joel L. Ramirez, Greg J. Zahner, Shipra Arya, S. Marlene Grenon, Warren J. Gasper, Julie Ann Sosa, Michael S. Conte, James C. Iannuzzi
Summary: This study identified an association between depression and nonhome discharge (NHD) after revascularization for CLTI. The presence of depression was linked to an increased risk of NHD, especially in endovascular revascularization cases. There was a higher odds of NHD in men with depression compared to women with depression, suggesting a gender difference in this association.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Agriculture, Multidisciplinary
Mohammad Zahirul Islam, Buem-Jun Park, Su-Yeon Jeong, Sun-Woong Kang, Bo-Kyung Shin, Young-Tack Lee
Summary: Drought stress increased the levels of biochemical compounds in barley grass and wheatgrass extracts, with wheatgrass showing higher phenolics, flavonoids, and vitamin C contents. Additionally, wheatgrass extracts exhibited significantly higher antioxidant enzyme activities compared to barley grass extracts under severe drought stress.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Oncology
Soon-Jung Park, Hyeok Kim, Sunghun Lee, Jongsoo Kim, Taek-Hee Jung, Seong Woo Choi, Bong-Woo Park, Sun-Woong Kang, David A. Elliott, Edouard G. Stanley, Andrew G. Elefanty, Kiwon Ban, Hun-Jun Park, Sung-Hwan Moon
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Woo Beom Ahn, Yu Bin Lee, Yi-Hwa Ji, Kyoung-Sik Moon, Hyon-Seok Jang, Sun-Woong Kang
Summary: This study developed a decellularized human adipose tissue matrix (DM) as an alternative graft material for bone defects. The DM showed the ability to form new bone tissue when implanted and had similar bone tissue regeneration efficiency compared to a commercial product. Therefore, this study provides an innovative solution to address the problem of insufficient graft materials.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hyosuk Kim, Byeong-Wook Song, Soon-Jung Park, Seong Woo Choi, Hanbyeol Moon, Ki-Chul Hwang, Sun-Woong Kang, Sung-Hwan Moon, Yoosoo Yang, Ick Chan Kwon, Sun Hwa Kim
Summary: This study proposes an extracellular vesicle (EV)-guided, nonviral, direct lineage conversion strategy to enhance the transdifferentiation of fibroblasts to induced cardiomyocyte-like cells (iCMs). The resulting iCMs show typical cardiac features and have gene expression profiles similar to cardiomyocytes. This method achieves a high conversion efficiency (>60%) and establishes a more accessible platform for generating specialized somatic cells through direct lineage conversion.
Article
Neurosciences
Hyun Joo Shin, Zhen Jin, Hyeong Seok An, Gyeongah Park, Jong Youl Lee, So Jeong Lee, Hye Min Jang, Eun Ae Jeong, Kyung Eun Kim, Jaewoong Lee, Dae Young Yoo, Gu Seob Roh
Summary: The results of the study indicate that LCN2 may promote hepatic inflammation and microglial activation via upregulation of TREM2 in diabetic mice. Deletion of LCN2 can attenuate metabolic parameters in diabetic mice and reduce the expression of hepatic and hippocampal TREM2.
Article
Cell Biology
Soo-Been Jeon, A-Reum Han, Sunghun Lee, Seung Chan Lee, Min Ji Lee, Soon-Jung Park, Sung-Hwan Moon, Ji Yoon Lee
Summary: In this study, a CD34(dim) subpopulation with hemogenic potential and a purified HE population that generated hematopoietic stem cells and lymphocytes were identified and validated. A simple method to purify HE cells enriched in CD34(dim) cells was developed. The findings revealed an initial step in differentiating hematopoietic lineage cells and its potential application in regenerative medicine.
CELL PROLIFERATION
(2023)
Article
Chemistry, Multidisciplinary
Thuy Trang Truong, Yu Bin Lee, Kyoung Hwan Park, Hye-Eun Shim, Jin Jung Song, Hyung-Sun Kim, Jeong Ho Hwang, Sun-Woong Kang, Kang Moo Huh
Summary: Three-dimensional (3D) spheroid culture is widely used, but time-consuming and unsuitable for urgent situations. Cryopreservation methods for spheroids are required for on-demand and ready-to-use applications. Short incubation periods were found to be suitable for the cryopreservation process, ensuring viability and migration of the spheroids. This study provides a chondrocyte-based ready-to-use spheroid system that can be applied to regenerative medicine and other cell types.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Engineering, Environmental
Kyoung Hwan Park, Bokyeong Ryu, Jin Jung Song, Hye-Eun Shim, Sun-Sook Song, Ji-Seok Han, C-Yoon Kim, Kang Moo Huh, Sun-Woong Kang
Summary: This study presents a new method for spheroid formation by incorporating hyaluronic acid (HA) microparticles in the culture. Spheroids containing HA microparticles exhibited enhanced cell migration activity, higher survival rate, and increased albumin secretion ability after transplantation in the liver of mice, compared to plain spheroids. This 3D cell culture system with HA microparticles shows promise in improving engraftment and efficiency of cell therapy for regenerative medicine.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
So-Jung Gwak, Yu Bin Lee, Eun Joo Lee, Kyoung Hwan Park, Sun-Woong Kang, Kang Moo Huh
Summary: The market for injectable dermal fillers is booming due to growing interest in appearance management. However, the durability and retention time of hyaluronic acid (HA) hydrogels, commonly used as fillers, are limited. This study introduces acetylated hyaluronic acid-divinyl sulfone (AcHA-DVS) hydrogels as a promising solution to improve the physical properties and gel retention time of HA fillers.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Polymer Science
Eun Young Koo, Kyoung Hwan Park, Sun-Woong Kang, Kang Moo Huh
Summary: In this study, effective 3D cell culture dishes were designed by optimizing the structure and coating stability of hexanoyl glycol chitosan (HGC) materials. Different HGCs with varying substitution ratios were synthesized and compared for their coating stability and 3D cell culture ability. Mesh-pattern culture dishes were also produced for mass-production of uniform-sized cell spheroids. HGC polymer with a substitution ratio of 36% or more showed high stability and spheroid formation ability, and the mesh-pattern culture dishes were effective for mass-production of uniform and controlled sizes.
Article
Agriculture, Multidisciplinary
Mohammad Zahirul Islam, Sun-Woong Kang, Na-Gyeong Koo, Ye-Jin Kim, Jae Kwang Kim, Young-Tack Lee
Summary: This study investigated the changes in bioactive compounds of Cassia tora seeds during germination. The results showed that the crude ash, crude fat, and crude protein content of the seeds slightly increased during the germination process. The study also found that the total carotenoid content, anthocyanin content, vitamin C content, phenolic content, and flavonoid content increased after germination, which subsequently increased the antioxidant activities.
COGENT FOOD & AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Jin-Ju Kim, Jae-Hyun Park, Hyeok Kim, Woo-Sup Sim, Seokbeom Hong, Yeon-Jik Choi, Hyo-Jin Kim, Soon Min Lee, Dongha Kim, Sun-woong Kang, Kiwon Ban, Hun-Jun Park
Summary: Researchers have developed a strategy using SDF1 alpha-engineered mesenchymal stem cells (SDF1 alpha-eMSCs) to simultaneously regenerate blood vessels and skeletal muscles in limbs experiencing ischemia. These cells can provide long-term paracrine effects, promoting vascular regeneration and skeletal muscle repair, and have potential as an effective therapeutic strategy for limb salvage in patients with critical limb ischemia.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Meeting Abstract
Cell & Tissue Engineering
Kyeong Eun Lee, Da Hyeon Choi, Sun-Woong Kang, Kang Moo Huh, Yoon Shin Park
TISSUE ENGINEERING PART A
(2022)
Article
Biochemistry & Molecular Biology
Hyeok Kim, Soon-Jung Park, Jae-Hyun Park, Sunghun Lee, Bong-Woo Park, Soon Min Lee, Ji-Won Hwang, Jin-Ju Kim, Byeongmin Kang, Woo-Sup Sim, Hyo-Jin Kim, Seung Hwan Jeon, Dong-Bin Kim, Jinah Jang, Dong-Woo Cho, Sung-Hwan Moon, Hun-Jun Park, Kiwon Ban
Summary: Researchers have successfully used a combination of two different types of stem cells to repair failed hearts by creating new blood vessels. This dual stem cell treatment improves cardiac function and results in a higher number of larger and stronger new blood vessels.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Materials Science, Biomaterials
Soon-Jung Park, Taek-Hee Jung, Jong Hyun Kim, Kyoung-Yong Lee, Jeongyun Kim, Jongil Ju, Sung-Hwan Moon
Summary: This study evaluated the application of computational fluid dynamics in an in silico-designed and spheroid-based 3D cell culture chip. The results demonstrated the usefulness of computational simulation in cell culture, drug screening, cytokine delivery, and differentiation. The study also showed that low flow rates could facilitate the formation of uniform cell spheroids, and advanced cell culture technologies have the potential to accelerate research and development of cell therapies.
BIOMATERIALS SCIENCE
(2022)
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)
