Post-modified metal-organic framework as a turn-on fluorescent probe for potential diagnosis of neurological diseases

Precise measurement of GSH in serum is of great significance for the prevention and diagnosis of neurological disorders such as schizophrenia and Alzheimer's. In this work, we incorporated Eu3+ and Cu2+ into UiO-67-bpydc to synthesize post-modified Eu3+/Cu2+@UiO-67-bpydc. Based on the interaction between thiol and Cu2+ ions, biomolecules containing sulfhydryl groups such as GSH can coordinate with Cu2+ chelated on Eu3+/Cu2+@UiO-67-6pydc and increase its fluorescence intensity, thus the post-modified Eu3+/Cu2+@UiO-67-bpydc can serve as a platform for the detection of GSH. It exhibits a sensitive Turn-on response in the detection of GSH over other biological interference can even select GSH from Cys. The LOD of Eu3+/Cu2+@UiO-67-bpydc was 54.3 nM in aqueous solution. Further fluorescence tests in physiological environment demonstrate that it can also be applied in serum for the diagnosis of neurological diseases.