Mycobacterium smegmatis moxifloxacin persister cells produce high levels of hydroxyl radical, generating genetic resisters selectable not only with moxifloxacin, but also with ethambutol and isoniazid

Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates

(2019) Etthel Martha Windels et al.   ISME Journal

Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic

(2019) Theresa C. Barrett et al.   Nature Communications

Heterogeneity of ROS levels in antibiotic-exposed mycobacterial subpopulations confers differential susceptibility

(2019) Rashmi Ravindran Nair et al.   MICROBIOLOGY-SGM

A Minor Subpopulation of Mycobacteria Inherently Produces High Levels of Reactive Oxygen Species That Generate Antibiotic Resisters at High Frequency From Itself and Enhance Resister Generation From Its Major Kin Subpopulation

(2019) Rashmi Ravindran Nair et al.   Frontiers in Microbiology

Validation of Novel Mycobacterium tuberculosis Isoniazid Resistance Mutations Not Detectable by Common Molecular Tests

(2018) Justin L. Kandler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mutations ingyrAandgyrBamong Fluoroquinolone- and Multidrug-Resistant Mycobacterium tuberculosis Isolates

(2016) Jung-Yien Chien et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

De Novo Emergence of Genetically Resistant Mutants of Mycobacterium tuberculosis from the Persistence Phase Cells formed against Antituberculosis Drugs In Vitro

(2016) Jees Sebastian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiotic resistance mechanisms in M. tuberculosis: an update

(2016) Liem Nguyen   ARCHIVES OF TOXICOLOGY

Real-time investigation of antibiotics-induced oxidative stress and superoxide release in bacteria using an electrochemical biosensor

(2016) Xiaobo Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Role of Reactive Oxygen Species in Antibiotic-Induced Cell Death in Burkholderia cepacia Complex Bacteria

(2016) Heleen Van Acker et al.   PLoS One

Deficiency of the Novel Exopolyphosphatase Rv1026/PPX2 Leads to Metabolic Downshift and Altered Cell Wall Permeability in Mycobacterium tuberculosis

(2015) Yu-Min Chuang et al.   mBio

Rifampin Induces Hydroxyl Radical Formation in Mycobacterium tuberculosis

(2014) Giovanni Piccaro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Mechanisms Underlying Bacterial Persisters

(2014) Etienne Maisonneuve et al.   CELL

Role of reactive oxygen species in the bactericidal action of quinolones as inhibitors of DNA gyrase

(2014) V. Yu. Kotova et al.   MOLECULAR BIOLOGY

Reengineering Redox Sensitive GFP to Measure Mycothiol Redox Potential of Mycobacterium tuberculosis during Infection

(2014) Ashima Bhaskar et al.   PLoS Pathogens

Acceleration of Tuberculosis Treatment by Adjunctive Therapy with Verapamil as an Efflux Inhibitor

(2013) Shashank Gupta et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

(2013) J. Cadet et al.   Cold Spring Harbor Perspectives in Biology

Mycobacterial MazG Safeguards Genetic Stability via Housecleaning of 5-OH-dCTP

(2013) Liang-Dong Lyu et al.   PLoS Pathogens

Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin againstPseudomonas aeruginosabiofilms

(2013) Peter Ø. Jensen et al.   Pathogens and Disease

Rapid Killing of Acinetobacter baumannii by Polymyxins Is Mediated by a Hydroxyl Radical Death Pathway

(2012) Timothy R. Sampson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibitors of Reactive Oxygen Species Accumulation Delay and/or Reduce the Lethality of Several Antistaphylococcal Agents

(2012) Yuanli Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sub-lethal concentrations of antibiotics increase mutation frequency in the cystic fibrosis pathogenPseudomonas aeruginosa

(2012) C.G. Nair et al.   LETTERS IN APPLIED MICROBIOLOGY

Mycoredoxin-1 is one of the missing links in the oxidative stress defence mechanism of Mycobacteria

(2012) Koen Van Laer et al.   MOLECULAR MICROBIOLOGY

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals

(2012) Sarah Schmidt Grant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

High Proportion of Fluoroquinolone-Resistant Mycobacterium tuberculosis Isolates with Novel Gyrase Polymorphisms and a gyrA Region Associated with Fluoroquinolone Susceptibility

(2011) R. Devasia et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Location of Intra- and Extracellular M. tuberculosis Populations in Lungs of Mice and Guinea Pigs during Disease Progression and after Drug Treatment

(2011) Donald R. Hoff et al.   PLoS One

Characterization and Transcriptome Analysis of Mycobacterium tuberculosis Persisters

(2011) I. Keren et al.   mBio

Highly fluorescent GFPm2+-based genome integration-proficient promoter probe vector to study Mycobacterium tuberculosis promoters in infected macrophages

(2011) Sougata Roy et al.   Microbial Biotechnology

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis

(2010) Michael A. Kohanski et al.   MOLECULAR CELL

Contribution of Oxidative Damage to Antimicrobial Lethality

(2009) X. Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fluoroquinolone Resistance in Mycobacterium tuberculosis and Mutations in gyrA and gyrB

(2009) A. Von Groll et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biphasic Kill Curve of Isoniazid Reveals the Presence of Drug‐Tolerant, Not Drug‐Resistant,Mycobacterium tuberculosisin the Guinea Pig

(2009) Zahoor Ahmad et al.   JOURNAL OF INFECTIOUS DISEASES

Novel role of Wag31 in protection of mycobacteria under oxidative stress

(2009) Partha Mukherjee et al.   MOLECULAR MICROBIOLOGY

Bacillithiol is an antioxidant thiol produced in Bacilli

(2009) Gerald L Newton et al.   Nature Chemical Biology

Defects in the Error Prevention Oxidized Guanine System Potentiate Stationary-Phase Mutagenesis in Bacillus subtilis

(2008) L. E. Vidales et al.   JOURNAL OF BACTERIOLOGY

Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes

(2008) Vishnu Karthik Jothivasan et al.   NATURAL PRODUCT REPORTS