Inhibition of PI3K/AKT/mTOR and MAPK signaling pathways decreases progranulin expression in ovarian clear cell carcinoma (OCCC) cell line: a potential biomarker for therapy response to signaling pathway inhibitors

ERK regulates HIF-1α-mediated platinum resistance by directly targeting PHD2 in ovarian cancer

(2019) Zhuqing Li et al.   CLINICAL CANCER RESEARCH

Novel Small Molecule MEK Inhibitor URML-3881 Enhances Cisplatin Sensitivity in Clear Cell Ovarian Cancer

(2019) Rachael B. Rowswell-Turner et al.   Translational Oncology

Ovarian cancer statistics, 2018

(2018) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma

(2018) Joseph J. Caumanns et al.   CLINICAL CANCER RESEARCH

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

PI3K/AKT/mTOR Pathway in Ovarian Cancer Treatment: Are We on the Right Track?

(2017) Maria Gasparri et al.   GEBURTSHILFE UND FRAUENHEILKUNDE

Progranulin and its biological effects in cancer

(2017) Fabian Arechavaleta-Velasco et al.   MEDICAL ONCOLOGY

Clinical implications of progranulin in gastric cancer and its regulation via a positive feedback loop involving AKT and ERK signaling pathways

(2017) Dong Yang et al.   Molecular Medicine Reports

Dual Inhibition of PI3K/AKT and MEK/ERK Pathways Induces Synergistic Antitumor Effects in Diffuse Intrinsic Pontine Glioma Cells

(2017) Y. Linda Wu et al.   Translational Oncology

Clear-cell carcinoma of the ovary

(2016) K. Fujiwara et al.   ANNALS OF ONCOLOGY

PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives

(2016) Vivek Asati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Clear cell carcinoma of the ovary: molecular insights and future therapeutic perspectives

(2016) Seiji Mabuchi et al.   Journal of Gynecologic Oncology

Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin

(2016) Simone Buraschi et al.   Oncotarget

Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling

(2016) Feng Liu et al.   Scientific Reports

Ovarian cancer

(2016) Ursula A. Matulonis et al.   Nature Reviews Disease Primers

Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers

(2016) Ryuta Tanimoto et al.   Frontiers in Endocrinology

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(2015) N. Siddiqui et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Potential targets for ovarian clear cell carcinoma: a review of updates and future perspectives

(2015) Shinya Matsuzaki et al.   Cancer Cell International

The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer

(2015) Seiji Mabuchi et al.   GYNECOLOGIC ONCOLOGY

PI3K/AKT/mTOR signaling pathway as a therapeutic target for ovarian cancer

(2014) HaiXia Li et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Elevated Expression of Secreted Autocrine Growth Factor Progranulin Increases Cervical Cancer Growth

(2014) Zhihong Wei et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

(2014) G. P. Dunn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two cases of recurrent ovarian clear cell carcinoma treated with sorafenib

(2013) Masafumi Koshiyama et al.   CANCER BIOLOGY & THERAPY

Utility of Progranulin and Serum Leukocyte Protease Inhibitor as Diagnostic and Prognostic Biomarkers in Ovarian Cancer

(2013) A. M. Carlson et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

PKC Signaling is Involved in the Regulation of Progranulin (Acrogranin/PC-Cell-Derived Growth Factor/Granulin-Epithelin Precursor) Protein Expression in Human Ovarian Cancer Cell Lines

(2012) Laura Diaz-Cueto et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Targeting mTOR Signaling Pathway in Ovarian Cancer

(2011) S. Mabuchi et al.   CURRENT MEDICINAL CHEMISTRY

Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian cancer cells

(2011) Yue Wang et al.   CYTOKINE

Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism

(2011) Gabriel Frampton et al.   GUT

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(2011) L Galluzzi et al.   ONCOGENE

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Expression of Progranulin (Acrogranin/PCDGF/Granulin-Epithelin Precursor) in Benign and Malignant Ovarian Tumors and Activation of MAPK Signaling in Ovarian Cancer Cell Line

(2010) R. Cuevas-Antonio et al.   CANCER INVESTIGATION

Granulin-Epithelin Precursor and ATP-Dependent Binding Cassette (ABC)B5 Regulate Liver Cancer Cell Chemoresistance

(2010) Siu Tim Cheung et al.   GASTROENTEROLOGY

Progranulin is a potential prognostic biomarker in advanced epithelial ovarian cancers

(2010) Jasmine J. Han et al.   GYNECOLOGIC ONCOLOGY

Hypoxia induces up-regulation of progranulin in neuroblastoma cell lines

(2010) Paola Piscopo et al.   NEUROCHEMISTRY INTERNATIONAL

mTOR Is a Promising Therapeutic Target Both in Cisplatin-Sensitive and Cisplatin-Resistant Clear Cell Carcinoma of the Ovary

(2009) S. Mabuchi et al.   CLINICAL CANCER RESEARCH

Cell Growth of Ovarian Cancer Cells is Stimulated by Xenoestrogens through an Estrogen-Dependent Pathway, but Their Stimulation of Cell Growth Appears not to be Involved in the Activation of the Mitogen-Activated Protein Kinases ERK-1 and p38

(2009) Se-Hyung PARK et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma

(2008) Hiroaki Itamochi et al.   CANCER SCIENCE

Ovarian Carcinoma Subtypes Are Different Diseases: Implications for Biomarker Studies

(2008) Martin Köbel et al.   PLOS MEDICINE