Review
Biotechnology & Applied Microbiology
Xia Zhao, Daniel A. Hu, Di Wu, Fang He, Hao Wang, Linjuan Huang, Deyao Shi, Qing Liu, Na Ni, Mikhail Pakvasa, Yongtao Zhang, Kai Fu, Kevin H. Qin, Alexander J. Li, Ofir Hagag, Eric J. Wang, Maya Sabharwal, William Wagstaff, Russell R. Reid, Michael J. Lee, Jennifer Moriatis Wolf, Mostafa El Dafrawy, Kelly Hynes, Jason Strelzow, Sherwin H. Ho, Tong-Chuan He, Aravind Athiviraham
Summary: Cartilage, especially articular cartilage, is crucial for joint function and mobility, but has limited self-repair capacity. Cartilage tissue engineering (CTE) holds promise for repair, requiring effective chondrogenic factors, ample chondrogenic progenitors, and cell-friendly, biocompatible scaffold materials for success. Progress in these areas, along with advancements in 3D bio-printing, may improve clinical outcomes of cartilage repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Polymer Science
Ssu-Meng Haung, Yu-Ting Lin, Shih-Ming Liu, Jian-Chih Chen, Wen-Cheng Chen
Summary: In this study, porous scaffolds made of gelatin, hyaluronic acid, alginate, and sucrose in different proportions were used for chondrocyte regeneration. The results showed that the scaffold with the highest porosity and strength did not perform the best, while another scaffold provided a more suitable environment for chondrocyte growth. Developing hydrogels with customized pore properties for defective cartilage is expected to meet the requirements of ultimate clinical applications.
Article
Multidisciplinary Sciences
Wenli Dai, Jin Cheng, Wenqiang Yan, Chenxi Cao, Fengyuan Zhao, Qi Li, Xiaoqing Hu, Jianquan Wang, Yingfang Ao
Summary: This study proposes a bioinspired osteochondral scaffold composed of natural polysaccharides and polypeptides for the repair of osteochondral defects. The scaffold exhibits excellent biocompatibility, biodegradability, and mechanical properties, and can integrate chondrogenic and osteogenic drugs. In experiments, the scaffold promotes the formation of hyaline cartilage and subchondral bone, displaying a heterogeneous nature resembling the natural landscape.
Article
Engineering, Biomedical
Zhuoyue Chen, Qiang Zhang, Hongmin Li, Qi Wei, Xin Zhao, Fulin Chen
Summary: By modifying silk fibroin (SF) scaffolds with engineered elastin-like polypeptides (ELP), cell adhesion and proliferation can be improved, leading to enhanced formation of mature bone and cartilage tissues.
BIOACTIVE MATERIALS
(2021)
Article
Biophysics
Chuan Guo, Zhenxing Cao, Yan Peng, Rui Wu, Hu Xu, Zhaoyang Yuan, Hui Xiong, Yu Wang, Ye Wu, Weilong Li, Qingquan Kong, Yi Wang, Jinrong Wu
Summary: Inspired by the microstructures of subchondral bone, a cell and cytokine free hydrogel scaffold for cartilage regeneration was developed, showing promising prospects in cartilage regeneration and various bioremediation applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Litao Jia, Peiling Zhang, Zheng Ci, Wei Zhang, Yu Liu, Haiyue Jiang, Guangdong Zhou
Summary: The study implanted xenogeneic ACM assisted with gelatin into goats and compared with PGA/PLA scaffold, demonstrating the potential of ACM/GT to promote cartilage formation and generate homogeneous and mature cartilage in large animals.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Yazhuo Huang, Lingyu Zhang, Yongrong Ji, Hongpei Deng, Mingce Long, Shengfang Ge, Yanjie Su, Siew Yin Chan, Xian Jun Loh, Ai Zhuang, Jing Ruan
Summary: In this study, a noninvasive and intelligent monitoring scaffold was developed using carboxylated carbon nanotubes (CNTs) integrated into chemically cross-linked carboxymethyl chitosan hydrogel. The CNT scaffold exhibited improved mechanical properties, good biocompatibility, and electrochemical responsiveness. It could sensitively monitor cell differentiation degree and enhance stem cell osteogenic differentiation for new bone tissue formation.
BIOACTIVE MATERIALS
(2023)
Article
Agriculture, Dairy & Animal Science
Einar Vargas-Bello-Perez, Andre Luis Alves Neves, Adrian Harrison
Summary: Recording rumen sounds can help assess the health status of a herd by analyzing the frequency and amplitude of rumen contractions. This study used a wireless device to record high-quality rumen sound waves and found that they can differentiate between cows of different production statuses and physiological stages. This technology has the potential to detect metabolic diseases early, but further studies are needed for validation.
Article
Instruments & Instrumentation
Parisa Ghandforoushan, Jalal Hanaee, Zahra Aghazadeh, Mohammad Samiei, Amir Mohammad Navali, Ali Khatibi, Soodabeh Davaran
Summary: Treating cartilage degenerative disorders is a longstanding challenge in orthopedic medicine due to the limited capacity for self-regeneration in cartilage. This study aimed to develop a nanocomposite biomaterial that enhances growth factor delivery to injured cartilage sites. The findings suggest that the developed nanocomposite hydrogel can serve as a supportive platform for promoting differentiation of human dental pulp stem cells.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sakchi Bhushan, Sandhya Singh, Tushar Kanti Maiti, Ankita Das, Ananya Barui, Leena R. Chaudhari, Meghnad G. Joshi, Dharm Dutt
Summary: Cell-free and cell-loaded constructs are used to repair critical-sized bone defects, with interest in enhancing three-dimensional scaffolds with free radical scavenging materials. In this study, CG-CNPs nanocomposite scaffolds with improved physico-chemical, mechanical, and biological properties were fabricated using freeze-drying. These scaffolds showed cyto-friendly behavior, antimicrobial activity, and demonstrated the best characteristics in terms of porosity, weight loss, compressive modulus, and Ca/P ratio. Therefore, the CG-CNP2 scaffolds are highly biocompatible and suitable for bone defect repair.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Kun Luo, Pengfei Gao, Weihu Yang, Xiaoyu Lei, Tuck-Whye Wong, Ahmad Fauzi Ismail, Li Wang
Summary: In this study, a 3D porous scaffold was prepared by incorporating citrate functionalized amorphous calcium phosphate into a polytetrahydrofuran based polyurethane scaffold. The obtained scaffold exhibited high porosity, appropriate pore size, and sufficient mechanical strength for cell adhesion and structural support. The scaffold also showed excellent antibacterial properties and biocompatibility, making it a potential candidate for minimally invasive alveolar bone regeneration.
APPLIED MATERIALS TODAY
(2023)
Review
Materials Science, Multidisciplinary
Arul Prakash Francis, Akshaya Rani Augustus, Sathyapriya Chandramohan, Suhail Ahmad Bhat, Veeraraghavan Vishnu Priya, Rukkumani Rajagopalan
Summary: Bone regeneration is an important field in orthopaedics and tissue engineering. The use of scaffolds as carriers for cells and growth factors has shown promising results in overcoming the issues caused by conventional bone repair methods. The versatility of biomaterials in terms of their physicochemical properties has led to better outcomes in bone regeneration. This review focuses on the fabrication of scaffolds and the various properties and applications of biomaterials, along with discussing the role of stem cells, growth factors, and signalling molecules in bone tissue regeneration.
MATERIALS TODAY COMMUNICATIONS
(2023)
Review
Biotechnology & Applied Microbiology
Walker D. D. Short, Oluyinka O. O. Olutoye, Benjamin W. W. Padon, Umang M. M. Parikh, Daniel Colchado, Hima Vangapandu, Shayan Shams, Taiyun Chi, Jangwook P. P. Jung, Swathi Balaji
Summary: Impaired wound healing is a significant financial and medical burden. Disruptions in ECM deposition, structure, and composition lead to impaired healing in diseased states, such as in diabetes. Valid measures include lack of bacterial contamination, good tissue perfusion, and reduced mechanical injury and strain. This review discusses bioengineering advances in detecting biologic and physiologic factors, visualizing and modeling the ECM, and efficiently evaluating wound data. It focuses on bioelectronics and biologic interfaces for real-time sensing and actuation, advanced imaging techniques, and computational modeling. These advancements have the potential to improve healing outcomes and guide decision-making in wound care.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Chengqi Lyu, Chi Cheng, YuShi He, Ling Qiu, Zijun He, Derong Zou, Dan Li, Jiayu Lu
Summary: Porous scaffolds are commonly used for cartilage tissue regeneration, but understanding the impact of their hierarchical structure on the regeneration process can be challenging. In this study, a graphene hydrogel with stable and adjustable structure was used as a model scaffold to investigate the effect of porous structure on matrix remodeling and chondrocyte ingrowth. The results showed that the graphene scaffold with an open pore structure accelerated and balanced cartilage remodeling. Furthermore, this enhanced remodeling selectively promoted the expression of collagen type II fibrils, providing new insights into scaffold design for cartilage repair.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Litao Jia, Peiling Zhang, Zheng Ci, Xiaoyan Hao, Baoshuai Bai, Wei Zhang, Haiyue Jiang, Guangdong Zhou
Summary: This study demonstrates that ACM-based biomimetic scaffolds combined with MNCs can be used for articular cartilage repair, improving the repair effect and suitable for large-scale clinical promotion.
MATERIALS TODAY BIO
(2022)
Review
Engineering, Biomedical
Bowen Tan, Lingxiao Huang, Yongzhi Wu, Jinfeng Liao
Summary: Water-based therapy has emerged as a promising option for cancer treatment due to its controllability, biocompatibility, high drug loading, prolonged drug release, and specific stimuli-sensitivity. It not only has good malleability to reach difficult-to-access areas, but also can serve as a carrier for tumor treatment agents and a scaffold for tissue repair.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Dentistry, Oral Surgery & Medicine
Bowen Tan, Quan Tang, Yongjin Zhong, Yali Wei, Linfeng He, Yanting Wu, Jiabao Wu, Jinfeng Liao
Summary: Maxillofacial tumours not only involve dealing with the tumours themselves, but also repairing jaw bone defects. Utilizing biomaterials can enhance tumour treatment efficiency, reduce recurrence and metastasis, and provide new promising anti-tumour therapies for patients.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Shengnan Liao, Wang Yue, Shuning Cai, Quan Tang, Weitong Lu, Lingxiao Huang, Tingting Qi, Jinfeng Liao
Summary: The review highlights the recent progress in the synthesis methods and surface functionalization of gold nanorods (GNRs) for photothermal therapy (PTT), focusing on reducing toxicity, increasing yield, controlling particle size and shape, and functionalizing the surface to enhance the photothermal effect of killing tumors. The study also proposes a brief outlook for the future development of GNRs modification and functionalization in PTT.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Bowen Tan, Yanting Wu, Yongzhi Wu, Kun Shi, Ruxia Han, Yiling Li, Zhiyong Qian, Jinfeng Liao
Summary: The study presents a hybrid hydrogel platform for the treatment of osteosarcoma and bone regeneration, using hyperthermia and curcumin to eradicate tumor cells and promote activation of bone mesenchymal stem cells. The gel turns into a gel through heat sensitivity for therapy, utilizing laser-induced hyperthermia and drug release to effectively kill tumor cells, ultimately achieving therapeutic and bone reconstruction outcomes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Biomaterials
Yanting Wu, Xu Zhang, Bowen Tan, Yue Shan, Xin Zhao, Jinfeng Liao
Summary: The development of bone tissue engineering has provided new avenues for bone defect repair. Polydopamine nanoparticles can be used in mild photothermal therapy to effectively treat bone defects. The GelMA/PMMA/PDA hydrogel, with improved mechanical properties and biocompatibility, exhibits favorable photothermal ability and osteogenic effect. In a rat skull defect model, the GelMA/PMMA/PDA hydrogel with mild PTT showed superior bone repair compared to other groups.
BIOMATERIALS ADVANCES
(2022)
Review
Biotechnology & Applied Microbiology
Tianyi Luo, Bowen Tan, Lengjing Zhu, Yating Wang, Jinfeng Liao
Summary: This review focuses on the importance of hydrogels in tissue engineering, particularly their effects on MSCs and macrophages in relation to stiffness. The relationship between changes in macrophage phenotype and inflammatory response for tissue repair is also discussed. Finally, the future applications of hydrogels in regenerative medicine and tissue engineering are considered.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Liren Cao, Yongzhi Wu, Yue Shan, Bowen Tan, Jinfeng Liao
Summary: This review presents the recent advancements in photothermal agents for oral cancer treatment, including metallic materials, carbon-based materials, and organic materials. The properties and synthesis of each photothermal agent are introduced, and current studies are summarized, along with their potential applications. Furthermore, the current status quo and deficiencies hindering the clinical application of photothermal therapy are discussed, providing insights into future development directions.
BIOMEDICAL MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Chengcheng Liu, Dan Tan, Xiaoli Chen, Jinfeng Liao, Leng Wu
Summary: Oral diseases are a global public health problem that cause significant financial burdens. Graphene nanomaterials have unique properties that make them suitable for dental therapies, such as restoration, drug delivery, and tissue regeneration. They can also adapt to the complex oral microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Yue Shan, Bowen Tan, Min Zhang, Xi Xie, Jinfeng Liao
Summary: A two-layered microneedle platform with the bifunctional effect of chemo-photothermal synergistic melanoma therapy and skin regeneration was developed. The microneedles showed excellent photothermal performance and tumor co-therapy ability, while the supporting backing layer promoted wound healing and skin regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Lingnan Zheng, Xi Yang, Yuanfeng Wei, Jia You, Huawei Li, Jinfeng Liao, Cheng Yi
Summary: Immune checkpoint blockade therapy has revolutionized cancer treatment, but it can lead to immune-related adverse events. Managing these events has been a significant concern, and researchers have explored various materials with specific properties to limit adverse events.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Applied
Xu Zhang, Bowen Tan, Yanting Wu, Min Zhang, Xi Xie, Jinfeng Liao
Summary: An injectable self-healing hydrogel with mild photothermal therapy has been developed to accelerate wound healing. The hydrogel improved mechanical strength and had photothermal conversion properties, achieving accelerated wound healing through in vitro cell proliferation and in vivo tissue regeneration. This research provides new inspirations for complicated wound management.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Biomaterials
Hongli Zhang, Xu Zhang, Qi Cao, Shuangquan Wu, Xiao-Qiang Wang, Na Peng, Danlin Zeng, Jinfeng Liao, Huan Xu
Summary: In this study, a multifunctional chitin/ZnO composite hydrogel was designed as a therapeutic material for infected skin wounds. The hydrogels exhibited excellent antibacterial activity and biocompatibility due to the tight binding of zinc oxide with chitin. Moreover, the hydrogels promoted accelerated wound healing by facilitating fibroblast proliferation, collagen deposition, and tissue regeneration.
BIOMATERIALS SCIENCE
(2022)
Review
Polymer Science
Mengjiao Cao, Chengcheng Liu, Mengxin Li, Xu Zhang, Li Peng, Lijia Liu, Jinfeng Liao, Jing Yang
Summary: This review summarizes the recent progress in incorporating different types of antibacterial agents into hydrogels and discusses the advantages and disadvantages of antibacterial agent hybrid hydrogels. It provides valuable insights and prospects for the treatment of infected bone defects.
Article
Polymer Science
Xu Han, Yongzhi Wu, Yue Shan, Xu Zhang, Jinfeng Liao
Summary: Joint diseases often cause articular cartilage injury, which is difficult to repair on its own. The micro-/nanoparticle hybrid hydrogel platform offers a new strategy for effective symptom control and cartilage repair, thanks to its excellent biocompatibility and controlled release effect.
Article
Chemistry, Multidisciplinary
Yongzhi Wu, Fangman Chen, Nengwen Huang, Jinjin Li, Chenzhou Wu, Bowen Tan, Yunkun Liu, Longjiang Li, Chao Yang, Dan Shao, Jinfeng Liao
Summary: Light-stimulus-responsive hydrogels incorporating mesoporous silica nanoparticles as doxorubicin carriers were developed for on-demand chemo-photothermal therapy of OSCC. The combination of chemotherapy and phototherapy achieved a long-lasting synergistic anti-tumor effect with less toxicity in vitro and in vivo.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
