Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 103, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2019.109854
Keywords
Gold nanorod; Hyaluronic acid; Hydroxyethyl chitosan; Charge-reversal; Dual-responsiveness; Combined chemo-photothermal therapy
Categories
Funding
- Key Research and Development Program of Shaanxi Province, China [2017SF-179, 2017SF-190]
- Foundation Project of The First Affiliated Hospital of Xi'an Jiaotong University [2016MS-04]
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Combination of different therapy modalities with multiple tumoricidal mechanisms has emerged as a promising anticancer strategy. Herein, we reported an aldehyde/catechol-functionalized hyaluronic acid (DAHA) and hydroxyethyl chitosan (HECS) decorated gold nanorod (GNR) platform for combined chemo-photothermal therapy of breast cancer. The DAHA was synthesized by conjugating dopamine onto oxidized hyaluronic acid. The nanoplatform was prepared by successively modifying GNR with DAHA via Au-catechol bonds, conjugating DOX onto DAHA moiety through Schiff base linkage, and coating HECS interlayer for charge-reversal and hyaluronic acid corona for tumor cell targeting. The resulting nanoplatform GNR-HA(DOX)CH exhibited acid triggered surface charge-reversal and pH/NIR dual-responsive drug release behaviors. The nanoplatform could be efficiently internalized into MCF-7 breast cancer cells and displayed greater cancer cell killing than individual modalities. Therefore, polysaccharide decoration could ensure the co-delivery of GNR and DOX into cancer cells, and the developed GNR-HA(DOX)CH holds great potential for breast cancer treatment.
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