Article
Oncology
Xuemei Pan, Ting Zhao, Saisai Mu, Shouchuan Li
Summary: miR-193a is downregulated in gastric cancer tissues and cell lines and predicts poor 5-year overall survival. It inhibits proliferation and activation of the PI3K/AKT signaling pathway in gastric cancer cells and impairs tumor growth in vivo. The newly identified miR-193a/PSEN1 axis provides novel insight into the pathogenesis of gastric cancer.
JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenxiu Liu, Hongyan Gou, Xiaohong Wang, Xiaoming Li, Xiaoxu Hu, Hao Su, Shengmian Li, Jun Yu
Summary: The study identified TTPAL as playing a crucial role in gastric cancer, promoting cancer cell proliferation, migration, and invasion through the PI3K/AKT signaling pathway, and may serve as a prognostic biomarker for GC patients.
Article
Biotechnology & Applied Microbiology
Guang-Cheng Luo, Lin Chen, Jiang Fang, Zhi-Jian Yan
Summary: This study revealed that hsa_circ_0030586 is significantly upregulated in prostate cancer cells and may promote epithelial-mesenchymal transition (EMT) through the PI3K-AKT signaling pathway. Experiment results showed that interfering with hsa_circ_0030586 could inhibit tumor cell proliferation, migration, and invasion in PCa.
Article
Genetics & Heredity
Qian Zhang, Jun Dan, Shuang Meng, Yingjie Li, Jing Li
Summary: This study investigated the role of Toll-like receptor 4 (TLR4) in autophagy and proliferation in gastric cancer (GC) cells. The levels of TLR4 were determined in different stages of GC cells/tissues using RT-qPCR and WB, along with the levels of autophagy-related proteins (ARPs) and the underlying signaling mechanism. Proliferation was assessed using the CCK-8 assay. The results revealed that modulation of the PI3K/AKT/mTOR pathway was induced by the overexpression and knockdown of TLR4, leading to inhibition/induction of autophagy, and TLR4 played a vital role in GC progression.
Article
Oncology
Yaobin Ouyang, Gongmeizi Liu, Wenting Xu, Zhen Yang, Nianshuang Li, Chuan Xie, Chun Zhou, Jiang Chen, Yin Zhu, Junbo Hong, Nonghua Lu
Summary: Helicobacter pylori infection induces EMT in the gastric mucosa by downregulating E-cadherin and upregulating N-cadherin expression, with AKT activation playing a key role in this process. Activation of AKT and inactivation of GSK3 beta by phosphorylation promotes early stage EMT and may serve as a prerequisite for gastric cancer development.
Article
Biochemistry & Molecular Biology
Qianxiu Li, Zhongxiu Zhu, Hanyu Zhang, Xu Wu, Huan Yang, Xiaobing Li, Wanping Li, Yueshui Zhao, Fukuan Du, Yu Chen, Jing Shen, Zhangang Xiao, Meijuan Chen, Fang Wang, Li Gu, Yuhong Sun, Lan Lu, Yuliang Jia, Mingxing Li
Summary: This study found that long non-coding RNA (lncRNA) RP11-93B14.5 facilitates tumor progression and regulates the PI3K/AKT signaling pathway in gastric cancer (GC). Bioinformatics analysis revealed that RP11-93B14.5 was upregulated in GC tissues. Knockdown of RP11-93B14.5 decreased cell viability and colony formation, and altered cell cycle distribution. RNA-seq analysis indicated that RP11-93B14.5 may modulate expression of S100A2 and TIMP2 genes.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Oncology
Danfang Wang, Jianhui Li, Wenhan Li
Summary: This study investigates the role of LHPP in gastric cancer (GC) and finds that LHPP acts as a tumor suppressor gene by inhibiting proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of GC cells. The underlying mechanism involves regulating the PI3K/AKT/mTOR pathway.
Article
Oncology
Fan Xu, Jiali Wang, Shuman Zhen, Yuqing Duan, Qingshan Li, Lihua Liu
Summary: The stemness characteristic of breast cancer is important for cancer recurrence and metastasis. This study found that C1ql4 is highly expressed in breast cancer tissues and cell lines, and its high expression is significantly correlated with malignancy. Mechanistically, C1ql4 promotes breast cancer cell stemness and EMT through the PI3K/AKT/NF-kB signaling pathway. Therefore, C1ql4 might be a potential target for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Fei Su, Ruowen Xiao, Rui Chen, Tianning Yang, Danwen Wang, Xinni Xu, Xiaoming Hou, Quanlin Guan, Maohui Feng
Summary: WIPF1 overexpression is an independent risk factor for poor prognosis in gastric cancer patients, promoting cell proliferation, invasion, and migration, as well as activating the PI3K/AKT signaling pathway.
Article
Cell Biology
Chen Mi, Dan Zhang, Yarui Li, Mudan Ren, Wenhui Ma, Guifang Lu, Shuixiang He
Summary: Gastric cancer ranks among the top three leading causes of cancer-related deaths globally. The dysregulation of miR-4677-3p has been linked to the modulation of invasion and migration in various cancer cell types. This study demonstrates that miR-4677-3p is down-regulated in gastric cancer tissues and cells, and over-expression of miR-4677-3p suppresses cell proliferation, migration, and invasion by targeting the CEMIP-PI3K/AKT signaling pathway axis.
Article
Oncology
Lan-Lan Lin, Fan Yang, Dong-Huan Zhang, Cong Hu, Sheng Yang, Xiang-Qi Chen
Summary: ARHGAP10 was found to have lower expression in NSCLC tissues compared with normal tissues, and overexpression of ARHGAP10 inhibited the migratory and invasive potential of lung cancer cells by suppressing EMT through the PI3K/Akt/GSK3 beta pathway. Activation of the IGF-1 signaling pathway can reverse the effects of ARHGAP10 on EMT regulation in NSCLC cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Wenjuan Chen, Yanjie Chen, Yun Qian, Jun Zhang, Xiaoshan Hu, Xiangyun Yan, Chengyao Jiang, Shuwen Yao, Qinlei Yu, Xiaohui Chen, Shuping Han
Summary: This study investigated the protective effects of casein-derived peptide YFYPEL on necrotizing enterocolitis (NEC). YFYPEL integration in the intestine increased survival and clinical conditions, lowered the incidence of NEC, alleviated bowel inflammation, and enhanced intestinal cell migration.
Review
Medicine, Research & Experimental
Martina S. Savova, Liliya Mihaylova, Daniel Tews, Martin Wabitsch, Milen I. Georgiev
Summary: Obesity is a growing disorder that damages patients' quality of life and increases healthcare costs. Developing safe and innovative prevention strategies and treatments for obesity is crucial. The pathophysiology of obesity is complex and involves multiple signaling pathways, including the PI3K/AKT pathway, which plays a critical role in metabolic homeostasis. Natural compounds have been shown to target the PI3K/AKT signaling pathway and have potential for managing obesity. This paper evaluates the druggability of PI3K as a target and suggests perspectives on using natural compounds to modulate the PI3K/AKT pathway for obesity management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xiao Wang, Qianqian Chen
Summary: FERMT1 silencing inhibits migration, invasion, and EMT of OSCC cells by inactivating the PI3K/AKT signaling pathway, suggesting FERMT1 as a novel and potential therapeutic target for anti-metastatic strategies in OSCC.
Article
Plant Sciences
Jianbo He, Hongjuan Fu, Cancan Li, Zhihui Deng, Hui Chang
Summary: Eriodictyol has a chemopreventive effect on breast carcinogenesis in vitro and in vivo through targeting circ_0007503 and inhibiting the PI3K/Akt pathway.
