Article
Neurosciences
Yu-Hua Hu, Bao-Hua Jiao, Cheng-Ye Wang, Jian-Liang Wu
Summary: RIP2 is involved in TMZ resistance through the regulation of the NF-κB/MGMT signaling pathway. Interference with NF-κB or MGMT activity may be a novel strategy for treating RIP2-positive TMZ-resistant glioma.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
I-Tsang Chiang, Yu-Chang Liu, Hua-Shan Liu, Ahmed Atef Ahmed Ali, Szu-Yi Chou, Tsung- Hsu, Fei-Ting Hsu
Summary: Our study found that regorafenib can enhance the efficacy of temozolomide against glioblastoma by inhibiting the CXCL12/CXCR4/ERK/NF-κB signaling pathway. Additionally, regorafenib can sensitize glioblastoma cells to temozolomide and reduce tumor size and prolong survival in animal models.
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Neurosciences
Xiao-Liang Wang, Bao-Hua Jiao, Jian-Liang Wu, Jian-Kai Yang, Yu-Hua Hu, Kai Cui
Summary: This study investigates the role of RIP2 in regulating the stemness of glioma cells and their resistance to chemotherapy. RIP2 was found to mediate resistance to temozolomide by activating the NF-kappa B pathway and upregulating the expression of CD133 and SOX-2, both of which are involved in stemness maintenance. Targeting the RIP2/NF-kappa B pathway may be a potential therapeutic strategy for temozolomide-resistant gliomas.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Cell Biology
Kamalakshi Deka, Yinghui Li
Summary: The NF-kappa B signaling pathway plays a major role in inflammation and innate immunity, and is also crucial for cancer initiation and progression. It consists of canonical and non-canonical pathways, with the canonical pathway being prevalent in various human malignancies and inflammation-related diseases. The non-canonical pathway is also increasingly recognized in disease pathogenesis.
Article
Oncology
Wei Yuan, Qian Zhang, Danling Gu, Chenfei Lu, Deobrat Dixit, Ryan C. Gimple, Yisu Gao, Jiancheng Gao, Daqi Li, Danyang Shan, Lang Hu, Lu Li, Yangqing Li, Shusheng Ci, Hao You, Linping Yan, Kexin Chen, Ningwei Zhao, Chuanhai Xu, Jianyun Lan, Dong Liu, Junxia Zhang, Zhumei Shi, Qiulian Wu, Kailin Yang, Linjie Zhao, Zhixin Qiu, Deguang Lv, Wei Gao, Hui Yang, Fan Lin, Qianghu Wang, Jianghong Man, Chaojun Li, Weiwei Tao, Sameer Agnihotri, Xu Qian, Stephen C. Mack, Nu Zhang, Yongping You, Jeremy N. Rich, Guan Sun, Xiuxing Wang
Summary: The study reveals the crucial roles of CXCL8 in maintaining the mesenchymal state of GSCs and M2-like TAM polarization in GBM, suggesting that targeting CXCL8 and its downstream effectors could effectively improve GBM treatment.
CLINICAL CANCER RESEARCH
(2023)
Article
Nutrition & Dietetics
Xiaoxuan Guo, Jing Qiu, Yongzhong Qian
Summary: 6-Shogaol exhibited preventive effects on sepsis-induced liver injury by inhibiting inflammatory pathways and oxidative enzyme damage, as confirmed by transcriptomic analysis. Overlapping genes related to inflammation pathways were identified in different treatment groups, indicating the potential mechanism of action for 6-shogaol in treating liver disorders associated with sepsis.
Review
Biochemistry & Molecular Biology
Pengfei Shi, Jie Xu, Hongjuan Cui
Summary: This article summarizes the pathogenesis of glioblastoma multiforme (GBM) and the therapeutic methods related to NF-κB signaling, aiming to improve the survival rate of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Zhong-Fang Shi, Guan-Zhang Li, You Zhai, Chang-Qing Pan, Di Wang, Ming-Chen Yu, Chi Liu, Wei Zhang, Xiao-Guang Yu
Summary: This study found that EGFRvIII activated the NF-κB pathway and regulated the expression of ALDH1A3, promoting the proneural-mesenchymal transition of GBM and reducing its sensitivity to TMZ. This provides an experimental basis for the selection of clinical drugs for GBM patients with EGFRvIII (+).
Article
Cell Biology
Xin Peng, Xiaoli Liu, Wanshan Hu, Yanling Zhou, Lianlian Ouyang, Xintong Peng, Yao Long, Jingyue Sun, Tania Tao, Ling Chen, Ying Shi, Yongguang Tao, Desheng Xiao, Shuang Liu
Summary: In lung adenocarcinoma, overexpression of HOXC11 is associated with worse survival and is regulated by IKK alpha. HOXC11 promotes lung cancer progression by enhancing the expression of SPHK1 through directly binding to its promoter region.
CELL DEATH & DISEASE
(2023)
Article
Pharmacology & Pharmacy
Jie Su, Wei Yin, Mengmeng Huo, Qing Yao, Liqiong Ding
Summary: In this study, the researchers discovered that lycorine, when used in combination with glioma cells, could inhibit cell growth, induce apoptosis, and generate reactive oxygen species. Additionally, lycorine disrupted the NF-kappa B signaling pathway and reduced drug resistance. These findings suggest that lycorine may be a potential treatment for glioma.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marina Kolesnichenko, Nadine Mikuda, Uta E. Hoepken, Eva Kaergel, Bora Uyar, Ahmet Bugra Tufan, Maja Milanovic, Wei Sun, Inge Krahn, Kolja Schleich, Linda Hoff, Michael Hinz, Michael Willenbrock, Sabine Jungmann, Altuna Akalin, Soyoung Lee, Ruth Schmidt-Ullrich, Clemens A. Schmitt, Claus Scheidereit
Summary: The study reveals that DNA double-strand breaks elicit two subsequent phases of NF-kappa B activation, with the first phase controlling anti-apoptotic gene expression and the second phase driving expression of senescence-associated genes.
Article
Biochemistry & Molecular Biology
Claudia Contadini, Alessandra Ferri, Marta Di Martile, Claudia Cirotti, Donatella Del Bufalo, Francesca De Nicola, Matteo Pallocca, Maurizio Fanciulli, Francesca Sacco, Gloria Donninelli, Alessia Capone, Elisabetta Volpe, Nadine Keller, Shunichiro Miki, Daisuke Kawauchi, Dwayne Stupack, Frank Furnari, Daniela Barila
Summary: Caspase-8 is involved in apoptosis, but its expression is often downregulated in cancer cells. This study found that the activated Src tyrosine kinase in cancer cells can phosphorylate Caspase-8, inhibiting its activity and promoting tumor growth through the activation of the NF kappa B signaling pathway.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Virology
Benjamin E. Nilsson-Payant, Skyler Uhl, Adrien Grimont, Ashley S. Doane, Phillip Cohen, Roosheel S. Patel, Christina A. Higgins, Joshua A. Acklin, Yaron Bram, Vasuretha Chandar, Daniel Blanco-Melo, Maryline Panis, Jean K. Lim, Olivier Elemento, Robert E. Schwartz, Brad R. Rosenberg, Rohit Chandwani, Benjamin R. TenOever
Summary: Research suggests that in SARS-CoV-2 infection, NF-kappa B activation plays a crucial role in viral replication in the absence of traditional IFN-I-related transcription factors. Silencing NF-kappa B transcription factors or using inhibitors can reduce virus replication. These findings contribute to a better understanding of SARS-CoV-2 replication mechanisms and provide a basis for the development of novel treatment approaches.
JOURNAL OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Jiaqiang Dong, Jiong Li, Yang Li, Zhikun Ma, Yongxin Yu, Cun-Yu Wang
Summary: The study reveals that super-enhancers play a critical role in the transcription of cancer stemness genes and pro-metastatic genes, effectively inhibiting CSC self-renewal and eliminating CSCs, providing a potential therapy for HNSCC.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.