Journal
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Volume 102, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jmbbm.2019.103516
Keywords
Trabecular bone; Zirconia scaffolds; Micro-CT based FE modelling; Mechanical properties
Funding
- HAMaBICoHybrid Additive Manufacturing for Bio-Inspired Components [PVE/CAPES/CNPq407035/2013-3UFSC/UMinho, NORTE-01-0145-FEDER-000018]
- FCT [UID/EEA/04436/2019, PTDC/EME-EME/31035/2017, IF/00423/2012, IF/01285/2015]
- Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000023]
- Portuguese Foundation for Science and Technology [SFRH/BD/99555/2014]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/99555/2014, PTDC/EME-EME/31035/2017] Funding Source: FCT
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The present study aims at developing a computational framework with experimental validation to determine the mechanical properties of zirconia foams for bone tissue engineering. A micro-CT based finite element model that allows characterizing the mechanical property of such cellular structures is developed. Micro-CT images are filtered to vanish noises and smooth boundaries before constructing 3D zirconia foams using an adaptive BodyCentered Cubic background lattice. In addition to micro-CT images, the local material property at the scaffold struts is measured using a micro-indentation test, which shows a considerable difference with that of common zirconia owing to the manufacturing process. The computational model also takes the plastic deformation of material into account employing the Voce law, a nonlinear isotropic hardening law, as well as Von-mises yield criterion. Zirconia foams with different pore sizes are manufactured using the replica method and their mechanical properties determined experimentally. Such experimental outcomes are to validate and demonstrate the capability of the developed model, which can be used for pre-operational evaluations and preclinical tests of zirconia scaffolds. The stress magnitude and distribution within the scaffold as well as plastic strains and flow stress of the zirconia scaffold are computed and analysed. Using the proposed approach, a deep insight into the association of macroscopic behaviour of the scaffold to microscopic features, e.g. strut waviness, Plateau border, thickness variation of cells, irregularity, microstructural variability, imperfections and strut's material property associated with to the manufacturing procedure, can be gained.
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