Article
Gastroenterology & Hepatology
Hiroshi Horie, Satoshi Ogiso, Tomoaki Yoh, Ken Fukumitsu, Takamichi Ishii, Kenji Omae, Etsuro Hatano
Summary: The impact of albumin-bilirubin (ALBI) score at post-hepatectomy hepatocellular carcinoma (HCC) recurrence on survival after recurrence (SAR) was investigated in this study. It was found that higher ALBI scores at recurrence were associated with poorer SAR. Factors such as ALBI scores at hepatectomy and post-hepatectomy liver failure (PHLF) & grade B were also found to be related to the ALBI score at recurrence.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
Ming-Hao Xu, Bin Xu, Chen-Hao Zhou, Zhong Xue, Zhao-Shuo Chen, Wen-Xin Xu, Cheng Huang, Xiao-Dong Zhu, Jian Zhou, Jia Fan, Hui-Chuan Sun, Ying-Hao Shen
Summary: This study aims to develop a nomogram for predicting PHLF grade B-C in patients with huge HCC, which can help identify patients at high risk of severe complications.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Giovanni Marasco, Luigina Vanessa Alemanni, Antonio Colecchia, Davide Festi, Franco Bazzoli, Giuseppe Mazzella, Marco Montagnani, Francesco Azzaroli
Summary: The ALBI grade can accurately predict the risk of PHLF in HCC patients undergoing LR, with individuals classified as ALBI grade 2 and 3 showing higher rates of PHLF compared to those classified as ALBI grade 1.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jin-Yu Shi, Li-Yang Sun, Bing Quan, Hao Xing, Chao Li, Lei Liang, Timothy M. Pawlik, Ya-Hao Zhou, Hong Wang, Wei-Min Gu, Ting-Hao Chen, Wan Yee Lau, Feng Shen, Nan-Ya Wang, Tian Yang
Summary: ALBI and APRI showed more accurate predictive ability for PHLF compared to Child-Pugh and MELD. The proposed predictive models and online calculators combining ALBI and APRI were useful tools for individually predicting the occurrence of PHLF among patients with HCC.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haiyi Long, Chuan Peng, Hong Ding, Yun Zheng, Jianhua Zhou, Wei Chen, Xian Zhong, Yifan Shi, Yu Duan, Xiaohua Xie, Ming Kuang, Xiaoyan Xie, Manxia Lin
Summary: A nomogram based on liver stiffness was developed and validated for predicting symptomatic post-hepatectomy in patients with hepatocellular carcinoma, which could help surgeons in managing HCC resection.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Karolin Dehlke, Linda Krause, Silvana Tyufekchieva, Anastasia Murtha-Lemekhova, Philipp Mayer, Artyom Vlasov, Ursula Klingmueller, Nikola S. Mueller, Katrin Hoffmann
Summary: This study investigates the expression of cytokines and growth factors in post-hepatectomy regeneration and finds that certain expression trajectories are associated with liver failure, morbidity, and mortality. Regression models can predict mortality following major liver resection based on preoperative cytokine and growth factor signatures. Liquid-biopsy based risk profiling can predict postoperative liver failure and mortality on the first day after surgery.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Wei-Fan Hsu, Kai-Chih Chang, Te-Hong Chen, Chien-Hung Lin, Ying-Chun Lin, Ming-Hung Tsai, Pei-Yu Chen, Hung-Wei Wang, Chia-Sheng Chu, Cheng-Yuan Peng
Summary: For patients with intermediate-stage hepatocellular carcinoma, the ALBI score shows the highest diagnostic value in predicting overall survival, while the Lok index also demonstrates high predictive value in patients without cirrhosis and those undergoing surgery.
Article
Multidisciplinary Sciences
Carolina Rio Bartulos, Karin Senk, Ragnar Bade, Mona Schumacher, Nico Kaiser, Jan Plath, Mathis Planert, Christian Stroszczynski, Jan Woetzel, Philipp Wiggermann
Summary: Monitoring disease progression is crucial for determining treatment strategies in liver disease patients, especially those with reversible conditions. However, there is a lack of suitable tools for monitoring liver function, calling for the development of such tools, given the expected increase in these diseases in the future.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Rene Staritzbichler, Pascal Hunold, Irina Estrela-Lopis, Peter Werner Hildebrand, Berend Isermann, Thorsten Kaiser
Summary: The study evaluated the potential application of Raman spectroscopy in medical laboratories for a variety of biomarkers, using serum samples from patients with liver disease. By combining Raman spectroscopy with routine diagnostics and utilizing complex mathematical algorithms, the study demonstrated the high potential of Raman spectroscopy to quantify multiple biomarkers simultaneously in medical laboratory diagnostics.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dongxiao Meng, Changhu Liang, Yuanwen Zheng, Ximing Wang, Keke Liu, Zhengyu Lin, Qiang Zhu, Xinya Zhao
Summary: Gadobenate dimeglumine-enhanced biliary imaging from the hepatobiliary phase is valuable in predicting post-hepatectomy liver failure in patients with hepatocellular carcinoma (HCC).
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Zhengqing Lei, Nuo Cheng, Anfeng Si, Pinghua Yang, Guangmeng Guo, Weihu Ma, Qiushi Yu, Xuan Wang, Zhangjun Cheng
Summary: A nomogram was developed to predict grade B/C post-hepatectomy liver failure in HCC patients undergoing major hepatectomy, showing more accurate ability than conventional scoring models like MELD and ALBI scores.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tomoaki Yoh, Antoine Perrot, Aurelie Beaufrere, Christian Hobeika, Riccardo Sartoris, Valerie Paradis, Valerie Vilgrain, Olivier Soubrane, Francois Cauchy, Maxime Ronot
Summary: This study examined the relationship between liver surface nodularity (LSN), chemotherapy-associated liver injury (CALI), and clinically relevant post-hepatectomy liver failure (CR-PHLF) in patients undergoing hepatectomy for colorectal liver metastases (CLM). The findings suggest that LSN >= 2.5 is significantly associated with CR-PHLF, while the association between LSN and CALI is not significant. LSN >= 2.5 and future liver remnant (FLR) < 30% were identified as significant preoperative predictors of CR-PHLF.
EUROPEAN RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yan Xu, Xiaoling Hu, Jiangbin Li, Rui Dong, Xiaoxi Bai
Summary: Through a retrospective study of patients undergoing hepatectomy, the I-PALBI score was found to be the most effective predictive model for PHLF, with improved prediction accuracy compared to other scoring systems.
DIGESTIVE DISEASES
(2021)
Article
Oncology
Changfeng Li, Qiang Wang, Mengda Zou, Ping Cai, Xuesong Li, Kai Feng, Leida Zhang, Ernesto Sparrelid, Torkel B. Brismar, Kuansheng Ma
Summary: The aim of this study was to develop and validate a prediction model based on preoperative enhanced magnetic resonance imaging to estimate the risk of post-hepatectomy liver failure (PHLF) in patients with hepatocellular carcinoma (HCC). A combined model, including clinicopathological risk factors and radiomics signature, outperformed other models and can be used to identify patients at high risk of PHLF.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Fei-Qi Xu, Tai-Wei Ye, Dong-Dong Wang, Ya-Ming Xie, Kang-Jun Zhang, Jian Cheng, Zun-Qiang Xiao, Si-Yu Liu, Kai Jiang, Wei-Feng Yao, Guo-Liang Shen, Jun-Wei Liu, Cheng-Wu Zhang, Dong-Sheng Huang, Lei Liang
Summary: This study investigated the association between preoperative albumin-bilirubin (ALBI) grades and the achievement of textbook outcomes (TO) in patients with hepatocellular carcinoma undergoing laparoscopic hepatectomy. The results showed that preoperative ALBI grade 2/3 was significantly associated with non-achievement of TO.
FRONTIERS IN ONCOLOGY
(2022)
