Article
Rheumatology
Jorgen Guldberg-Moller, Mette Mogensen, Karen Ellegaard, Ali Zavareh, Richard J. Wakefield, Ai Lyn Tan, Mikael Boesen, Jamshid Dehmeshki, Olga Kubassova, Lene Dreyer, Marius Henriksen, Lars Erik Kristensen
Summary: The study investigated the ability of ultrasound, MRI, and X-ray to differentiate between psoriatic arthritis, skin psoriasis, and hand osteoarthritis based on findings in the distal interphalangeal joint and synovio-entheseal complex. The presence of new bone formation was identified as a characteristic of osteoarthritis, reducing the risk of psoriatic arthritis. Differences were observed in MRI and X-ray outcomes between osteoarthritis and psoriatic arthritis/skin psoriasis, with a lower risk associated with the latter. No specific outcome in ultrasound, MRI, or X-ray was significantly associated with a higher risk of psoriatic arthritis compared to skin psoriasis, although trends were noted in ultrasound erosions and new bone formation.
Review
Radiology, Nuclear Medicine & Medical Imaging
Ana Maria Crespo-Rodriguez, Jesus Sanz Sanz, Dalifer Freites, Zulema Rosales, Lydia Abasolo, Juan Arrazola
Summary: Psoriasis is a common skin disease that can develop into psoriatic arthritis (PsA) in up to 30% of patients, leading to impaired function and reduced quality of life. Early diagnosis and effective treatments are crucial for halting PsA progression. Sensitive imaging techniques such as ultrasound and MRI play an important role in the diagnosis, follow-up, and prognosis of PsA.
INSIGHTS INTO IMAGING
(2021)
Article
Rheumatology
Michaela Koehm, Sarah Ohrndorf, Ann C. Foldenauer, Tanja Rossmanith, Marina Backhaus, Stephanie G. Werner, Gerd R. Burmester, Siegfried Wassenberg, Benjamin Koehler, Harald Burkhardt, Frank Behrens
Summary: The study evaluated the efficacy of FOI technology in detecting early musculoskeletal inflammatory signs in patients with skin psoriasis, providing a useful method for early diagnosis of psoriatic arthritis.
Review
Biochemistry & Molecular Biology
Iwona Sudol-Szopinska, Nele Herregods, Andrea S. Doria, Mihra S. Taljanovic, Piotr Gietka, Nikolay Tzaribachev, Andrea Sabine Klauser
Summary: Over the past decade, imaging techniques for inflammatory arthritis in juvenile arthropathies have significantly improved, allowing for more accurate assessment and diagnosis. Ultrasound and magnetic resonance imaging have seen advancements in resolution, sensitivity, and diagnostic possibilities.
Article
Rheumatology
Ari Polachek, Victoria Furer, Mirna Zureik, Sharon Nevo, Liran Mendel, David Levartovsky, Jonathan Wollman, Valerie Aloush, Reut Tzemach, Ofir Elalouf, Marina Anouk, Mark Berman, Ilana Kaufman, Or Carmi, Yael Lahat, Tali Eviatar, Hagit Padova, Hagit Sarbagil-Maman, Sara Borok, Adi Broyde, Lihi Eder, Daphna Paran, Ori Elkayam
Summary: This study found that ultrasound has a significantly greater value than composite clinical scores in the assessment of disease activity in PsA patients with FMS. Patients with both PsA and FMS had significantly higher clinical composite indices scores, while their ultrasound scores were similar to those without FMS.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Orthopedics
Ruth Stoklund Thomsen, Tom Ivar Lund Nilsen, Glenn Haugeberg, Beathe Sitter, Arthur Kavanaugh, Susanne Juhl Pedersen, Mari Hoff
Summary: In patients with PsA and low to moderate disease activity, there was no clear evidence of increased inflammation objectively measured after HIIT exercise, as evaluated by US and MRI.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Rheumatology
Irina Gessl, Claudia A. Hana, Thomas Deimel, Martina Durechova, Miriam Hucke, Victoria Konzett, Mihaela Popescu, Paul Studenic, Gabriela Supp, Michael Zauner, Josef S. Smolen, Daniel Aletaha, Peter Mandl
Summary: The study aimed to assess the predictive value of tenderness in non-swollen joints for subsequent radiographic progression in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), taking into consideration other potential risk factors. Clinical and sonographic examination of hand joints were performed on patients with RA and PsA. The results showed that tenderness in non-swollen joints was associated with radiographic progression in RA, while the impact was weaker in PsA. Other risk factors such as sonographic signs for synovitis and baseline radiographic damage also had an effect on subsequent structural damage in both diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, General & Internal
Ivan Giovannini, Alen Zabotti, Carmelo Ciccio, Matteo Salgarello, Lorenzo Cereser, Salvatore De Vita, Ilaria Tinazzi
Summary: The frequent involvement of the spine and sacroiliac joint in Psoriatic Arthritis (PsA) has led to its classification within the Spondyloarthritis group, although a clear distinction between PsA and Spondyloarthritis remains challenging. Axial involvement, ranging from 25 to 70% in PsA patients, must be taken into consideration alongside peripheral involvement for disease management. The lack of consensus in defining axial involvement in PsA has led to varying interpretations over the years, highlighting a need for improved clinical and radiological assessment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Ari Polachek, Victoria Furer, Mirna Zureik, Sharon Nevo, Liran Mendel, David Levartovsky, Jonathan Wollman, Valerie Aloush, Reut Tzemah, Ofir Elalouf, Marina Anouk, Mark Berman, Ilana Kaufman, Yael Lahat, Hagit Sarbagil-Maman, Sara Borok, Adi Broyde, Lihi Eder, Daphna Paran, Moshe Iluz, Iris Eshed, Ori Elkayam
Summary: This study compared the discrepancies and agreements between US, MRI, and radiography of the hand in PsA. It found that US and MRI showed good agreement in detecting inflammatory changes, while US, radiography, and MRI had good-to-very good agreement in detecting destructive changes in PsA finger joints.
Article
Rheumatology
Sara Kamp Felbo, Charlotte Wiell, Mikkel Ostergaard, Rene Panduro Poggenborg, Pernille Boyesen, Hilde Berner Hammer, Annelies Boonen, Susanne Juhl Pedersen, Inge Juul Sorensen, Ole Rintek Madsen, Ole Slot, Jakob Mollenbach Moller, Marcin Szkudlarek, Lene Terslev
Summary: This study investigated the association between clinical joint tenderness and intra- and periarticular inflammation as assessed by ultrasound and MRI in patients with active PsA. The results showed a weak association between joint tenderness and inflammation, particularly in patients with high levels of pain, disability, and low mental health.
Article
Medicine, General & Internal
Daniel B. Abrar, Christoph Schleich, Miriam Frenken, Stefan Vordenbaeumen, Jutta Richter, Matthias Schneider, Benedikt Ostendorf, Sven Nebelung, Philipp Sewerin
Summary: The study found that the molecular composition of MCP and PIP joint cartilage in PsA and RA patients is similar when evaluated by dGEMRIC, demonstrating the scientific and clinical feasibility of compositional magnetic resonance imaging in these diseases. Additionally, there were no significant differences in joint space width between the two diseases.
Article
Oncology
Andrea Fulco, Francesco Chiaradia, Luigi Ascalone, Vincenzo Andracchio, Antonio Greco, Manlio Cappa, Marcello Scarcia, Giuseppe Mario Ludovico, Vincenzo Pagliarulo, Camillo Palmieri, Stefano Alba
Summary: The study compared the diagnostic accuracy of multiparametric MRI with fusion ultrasound-guided prostate biopsy and standard biopsy, showing that the combined targeted and standard biopsy approach can reduce the risk of missing clinically significant prostate cancer.
Article
Rheumatology
Fabian Proft, Susanne Lueders, Theresa Hunter, Gustavo Luna, Valeria Rios Rodriguez, Mikhail Protopopov, Katharina Meier, Georgios Kokolakis, Kamran Ghoreschi, Denis Poddubnyy
Summary: A dermatologist-centred screening tool followed by a structured rheumatological examination, including MRI, can be effective in recognizing psoriatic arthritis with axial involvement.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Soren Andreas Just, Christian Nielsen, Jens Christian Werlinrud, Pia Veldt Larsen, Eva Kildall Hejbol, Helene Broch Tenstad, Henrik Daa Schroder, Torben Barington, Trine Torfing, Frances Humby, Hanne Lindegaard
Summary: In this study, fibrocyte levels in blood and synovial tissue of patients with rheumatoid arthritis were found to correlate with disease activity, imaging, and pulmonary function changes. Despite effective RA treatment, fibrocyte levels did not decrease during the trial. An increase in synovitis in the early RA group was strongly correlated with higher levels of circulating and synovial fibrocytes.
Article
Engineering, Chemical
Wiktoria Odrzywolek, Anna Deda, Julita Zdrada, Dominika Wcislo-Dziadecka, Aleksandra Lipka-Trawinska, Barbara Blonska-Fajfrowska, Slawomir Wilczynski
Summary: This study quantitatively compared psoriatic skin with skin without psoriatic lesions using noninvasive imaging methods. The results showed significant differences in skin density, epidermis thickness, blood perfusion, temperature, and reflectance between psoriatic and unaffected skin. These parameters can be useful for monitoring the course of psoriasis and its treatment.
Article
Rheumatology
Sahil Koppikar, Keith Colaco, Paula Harvey, Shadi Akhtari, Vinod Chandran, Dafna D. Gladman, Richard Cook, Lihi Eder
Summary: This study aimed to assess the incidence and risk factors for heart failure in patients with psoriatic disease and describe their electrocardiographic and echocardiographic findings. The results showed that heart failure was associated with a combination of known cardiovascular risk factors and measures of disease activity, particularly in nonischemic heart failure.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Samantha Sarabia, Chandra Farrer, Jensen Yeung, Dana Jerome, Richard J. Cook, Lihi Eder
Summary: Combining MSK-US with a screening questionnaire improves the triage of patients with suspected PsA.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Lihi Eder, Ruth Croxford, Aaron M. Drucker, Arielle Mendel, Bindee Kuriya, Zahi Touma, Sindhu R. Johnson, Richard Cook, Sasha Bernatsky, Nigil Haroon, Jessica Widdifield
Summary: Compared with the general population, patients with immune-mediated inflammatory diseases (IMIDs) were more likely to be tested for SARS-CoV-2, but the infection rate was similar. The odds of SARS-CoV-2 infection varied across different IMID subgroups.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Jessica Widdifield, Lihi Eder, Simon Chen, Jeffrey C. Kwong, Carol Hitchon, Diane Lacaille, J. Antonio Avina-Zubieta, Lawrence W. Svenson, Sasha Bernatsky
Summary: This study assessed the uptake of COVID-19 vaccines among individuals with immune-mediated inflammatory diseases (IMIDs) and the general population in Ontario. The results showed that IMID patients had higher vaccination rates compared to the general population, particularly among those with stronger immune responses.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Veena K. Ranganath, Antonio La Cava, Sitaram Vangala, Jenny Brook, Tanaz A. Kermani, Daniel E. Furst, Mihaela Taylor, Gurjit S. Kaeley, Catherine Carpenter, David A. Elashoff, Zhaoping Li
Summary: A weight loss intervention programme can help obese rheumatoid arthritis (RA) patients achieve weight loss and improve their clinical disease activity and ultrasound synovitis measures. However, further studies are needed to validate these findings and improve the clinical management of obese RA patients.
Article
Rheumatology
Sanjana Tarannum, Jessica Widdifield, C. Fangyun Wu, Sindhu R. Johnson, Paula Rochon, Lihi Eder
Summary: This study compared patterns of healthcare utilization between male and female patients with inflammatory arthritis (IA). The findings showed that female patients had higher healthcare utilization than male patients before and after diagnosis, possibly indicating biological differences in disease course or sociocultural differences in healthcare-seeking behavior.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Lihi Eder, Ashish J. Mathew, Philippe Carron, Heidi Bertheussen, Juan D. Canete, May Azem, Andrea Delle Sedie, Carlo Salvarani, Roberto Ranza, Ashley Elliott, Anthony Turkiewicz, Ricardo Acayaba de Toledo, Hulya Bukulmez, Maria S. Stoenoiu, Arthur M. Mandelin II, Michaela Koehm, Chris A. Lindsay, Evan Siegel, Philip J. Mease
Summary: This article summarizes existing evidence regarding pharmaceutical and nonpharmaceutical interventions for enthesitis in patients with psoriatic arthritis (PsA) to facilitate an evidence-based update of the Group for Research and Assessment in Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for PsA. The article found several classes of systemic conventional and advanced therapies and local measures were recommended for active enthesitis in patients with PsA.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Timothy S. H. Kwok, Bindee Kuriya, Lauren K. King, Lihi Eder, J. Carter Thorne, Zhiyin Li, Therese Stukel, Longdi Fu, Alexander Kopp, Jessica Widdifield
Summary: This study described the changes in service delivery and access to rheumatologists during the COVID-19 pandemic in Ontario, Canada. The study found a significant decrease in outpatient office visits and a rise in telemedicine visits. There was also a decrease in new patient consultations over time, raising concerns for potential delays to diagnosis.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Abel Davtyan, Jennifer J. Y. Lee, Lihi Eder, Gillian A. Hawker, Jin Luo, Claire E. H. Barber, J. Carter Thorne, Jessica Widdifield
Summary: A study found that continuity of rheumatology care influences rates of emergency department visits and hospitalizations in patients with rheumatoid arthritis (RA). Patients who received continuous rheumatology care during the first 5 years after diagnosis had lower rates of ED visits and hospitalizations compared to those who did not receive continuous care. This study provides evidence supporting the value of early and continuous rheumatology care for reducing hospitalizations and ED visits.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Gurjit S. Kaeley, Georg Schett, Philip G. Conaghan, Dennis McGonagle, Frank Behrens, Philippe Goupille, Corine Gaillez, Bhumik Parikh, Catherine Bakewell
Summary: This study evaluated the treatment response of enthesitis in PsA patients treated with secukinumab or adalimumab for 52 weeks. The results showed that both drugs had similar efficacy in resolving enthesitis, including time to resolution. The authors concluded that inhibition of IL-17 with secukinumab reduced clinical enthesitis similarly to TNF-alpha inhibition with adalimumab.
Article
Rheumatology
Lihi Eder, Dafna D. Gladman, Philip Mease, Remy A. Pollock, Rayana Luna, Sibel Z. Aydin, Alexis Ogdie, Ari Polachek, David Gruben, Mary Jane Cadatal, Cassandra Kinch, Vibeke Strand
Summary: This study evaluated the impact of sex on the efficacy, safety, and persistence of tofacitinib in patients with psoriatic arthritis. The results showed that tofacitinib significantly improved disease symptoms in both male and female patients, with comparable efficacy. However, females had a slightly lower achievement rate of optimal disease control compared to males. There were no significant differences in safety and treatment persistence between sexes.
Article
Rheumatology
Lihi Eder, Ker-Ai Lee, Vinod Chandran, Jessica Widdifield, Aaron M. Drucker, Christopher Ritchlin, Cheryl F. Rosen, Richard J. Cook, Dafna D. Gladman
Summary: The study aimed to develop a risk prediction model for psoriasis patients to predict their risk of developing psoriatic arthritis (PsA) and evaluate its performance. The results showed that using readily available clinical variables, the development of PsA within clinically meaningful time frames can be predicted with reasonable accuracy for psoriasis patients.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Keith Colaco, Ker-Ai Lee, Shadi Akhtari, Raz Winer, Vinod Chandran, Paula Harvey, Richard J. Cook, Vincent Piguet, Dafna D. Gladman, Lihi Eder
Summary: This study developed and validated a five-year disease-specific cardiovascular risk prediction model for patients with psoriatic disease (PsD). The results indicate that traditional cardiovascular risk factors alone are effective in predicting cardiovascular risk in PsD patients.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Ying Ying Leung, Lihi Eder, Ana-Maria Orbai, Laura C. Coates, Maarten de Wit, Josef S. Smolen, Uta Kiltz, Penelope Palominos, Juan D. Canete, Rossana Scrivo, Andra Balanescu, Emanuelle Dernis, Sandra Meisalu, Martin Soubrier, Umut Kalyoncu, Laure Gossec
Article
Rheumatology
Christina Charles-Schoeman, Jennifer Wang, Ani Shahbazian, Holly Wilhalme, Jenny Brook, Gurjit S. Kaeley, Buzand Oganesian, Ami Ben-Artzi, David A. Elashoff, Veena K. Ranganath
Summary: Active rheumatoid arthritis (RA) is associated with increased cardiovascular risk and impaired function of high-density lipoprotein (HDL). The study evaluated the association between synovial power doppler ultrasound signal (PDUS) and HDL function and structure. Patients with higher baseline PDUS scores had worse HDL function, and treatment with tocilizumab or abatacept led to improvements in HDL function. These findings support previous research suggesting a direct link between joint inflammation and abnormal HDL function.
RHEUMATOLOGY INTERNATIONAL
(2023)
