Review
Immunology
Si-yue Zhai, Michael G. Kong, Yu-min Xia
Summary: Skin diseases can be categorized into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The underlying causes include microbial infections, autoimmune responses, abnormal cellular proliferation or differentiation, and excessive production of inflammatory factors. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has shown promising efficacy in dermatology by inhibiting infections, promoting wound healing, suppressing cancer growth, and improving psoriasis or vitiligo lesions. This review summarizes recent advances in CAP therapies for various skin diseases and proposes future strategies for increasing effectiveness and expanding clinical indications.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Applied
M. Dharini, S. Jaspi, R. Mahendran
Summary: Cold plasma, generated at room temperature, consists of reactive species that cause chemical and physical changes in biological materials. Its applications in food aim to ensure safety, quality, and property modification. However, our understanding of the mechanisms behind these alterations is limited, with only a few reactive oxygen and nitrogen species being extensively studied. This review explores the use of different feed gases to modify species composition and highlights the importance of considering all reactive species in food modification, along with the potential of molecular dynamics simulation to bridge the knowledge gap.
Article
Nanoscience & Nanotechnology
Nishtha Gaur, Bethany L. Patenall, Bhagirath Ghimire, Naing T. Thet, Jordan E. Gardiner, Krystal E. Le Doare, Gordon Ramage, Bryn Short, Rachel A. Heylen, Craig Williams, Robert D. Short, Toby A. Jenkins
Summary: We introduce a versatile drug-loaded composite hydrogel that can simultaneously deliver a drug and CAP-generated molecules in a tissue target when activated by an argon-based cold atmospheric plasma jet. We demonstrated this concept by encapsulating gentamicin in sodium polyacrylate particles dispersed within a poly(vinyl alcohol) hydrogel matrix. The resulting gentamicin-PAA-PVA composite hydrogel can release gentamicin and effectively eradicate bacteria, including those in planktonic state and biofilm, when activated by CAP. The concept of the composite hydrogel can also be applied to other antimicrobial agents like cetrimide and silver, and activated by any dielectric barrier discharge CAP device.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Environmental
Yawen Gao, Mingbo Li, Chao Sun, Xuehua Zhang
Summary: This study reports a new method for enhancing plasma activation efficiency in water flow using bubbles. Experimental results show that this method can achieve more than 5 times higher activation efficiency compared to the configuration without bubbles under the same energy input. Computational fluid dynamic simulations were also conducted to analyze the gas volume fraction, pressure, velocity distributions, and bubble behaviors.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Namkyung Kim, Seunghun Lee, Soyoung Lee, Jinjoo Kang, Young-Ae Choi, Jeongsu Park, Chul-Kyu Park, Dongwoo Khang, Sang-Hyun Kim
Summary: A cold atmospheric plasma (CAP) patch was developed for the treatment of skin diseases, especially psoriasis. The patch induces the opening of calcium channels in keratinocytes and generates ROS/RNS, improving psoriatic symptoms. It can be used as a combination therapy with existing drugs, reducing side effects.
Article
Infectious Diseases
Isabell Plattfaut, Manuela Besser, Anna-Lena Severing, Ewa K. Stuermer, Christian Oplaender
Summary: The antibacterial effects of CAP on Staphylococcus aureus were not significant, with no desired disinfection or reduction in bacterial burden in wet environments or biofilms. CAP treatment is not recommended as a standalone antibacterial therapy for wounds, but could be used to supplement standard treatments.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Review
Multidisciplinary Sciences
Neha Kaushik, Sarmistha Mitra, Eun Jung Baek, Linh Nhat Nguyen, Pradeep Bhartiya, June Hyun Kim, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: This review critically examines methods for generating reactive oxygen species (ROS) and explores their potential as a solution for virus deactivation. The study highlights the ability of ROS to directly eradicate pathogens through oxidative stress and indirectly through non-oxidative mechanisms. Additionally, the novel and environmentally friendly cold plasma delivery system for virus destruction is discussed in detail.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Chemistry, Analytical
Zahra Nasri, Giuliana Bruno, Sander Bekeschus, Klaus-Dieter Weltmann, Thomas von Woedtke, Kristian Wende
Summary: The study presented the development of an electrochemical sensor for in-situ assessment of reactive species in redox-based therapies, enabling the detection of the production of reactive oxygen and nitrogen species like hydrogen peroxide through chronoamperometry at different potentials.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Plant Sciences
Evgeny M. Konchekov, Leonid Kolik, Yury K. Danilejko, Sergey Belov, Konstantin Artem'ev, Maxim E. Astashev, Tatiana Pavlik, Vladimir Lukanin, Alexey Kutyrev, Igor G. Smirnov, Sergey Gudkov
Summary: A garden plant grafting technique enhanced by cold plasma and plasma-treated solutions is introduced for the first time. It has been demonstrated that this technique can significantly increase the growth and root collar diameter of Pyrus communis L., indicating the formation of a more developed vascular system at the graft interface.
Review
Biochemistry & Molecular Biology
Sunil Kumar Dubey, Shraddha Parab, Amit Alexander, Mukta Agrawal, Vaishnav Pavan Kumar Achalla, Udit Narayan Pal, Murali Monohar Pandey, Prashant Kesharwani
Summary: Cold atmospheric plasma therapy is a novel, simple, non-invasive treatment approach mainly used in wound healing. It is distinct from blood plasma and is generated as the fourth state of matter through irradiation or electric field. This review emphasizes the application of cold plasma in wound healing, discussing wound types, healing process, and mechanisms of cold atmospheric plasma therapy.
PROCESS BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Ahmed Yaseen Alqutaibi, Abdulbari Aljohani, Abdullah Alduri, Abdulmajid Masoudi, Anas M. Alsaedi, Hesham Mohammed Al-Sharani, Ahmed E. Farghal, Ahmad Abdulkareem Alnazzawi, Afaf Noman Aboalrejal, Abdel-Aleam H. Mohamed, Muhammad Sohail Zafar
Summary: This systematic review examines the bactericidal properties of cold atmospheric plasma (CAP) when used on various dental implant surfaces. The review found that CAP effectively reduces bacterial loads and combats biofilm and plaque formation on implant surfaces, leading to improved outcomes for implant patients.
Article
Immunology
Haowei Zhao, Xu Wang, Zhuo Liu, Ye Wang, Ling Zou, Yu Chen, Qi Han
Summary: The aim of this study was to design and optimize a cold atmospheric plasma (CAP) device and investigate its effects on plaque biofilm metabolism, microbial flora composition, and enamel demineralization in an oral environment. CAP had a short-term antibacterial effect on caries-related biofilms and inhibited acid production. It also showed a downregulation effect on Lactococcus in saliva biofilms. CAP-treated enamels were more resistant to acid demineralization.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Oncology
Ruby Limanowski, Dayun Yan, Lin Li, Michael Keidar
Summary: Cold atmospheric plasma (CAP), generated under atmospheric pressure conditions, is an ionized gas with reactive components and near-room temperature nature. CAP has promising applications in various medical fields, including microorganism sterilization, biofilm inactivation, wound healing, and cancer therapy. In vitro demonstrations of CAP-based cancer treatments have been reported, but preclinical and in vivo studies are crucial for achieving clinical application. This article summarizes the current status and development of preclinical usage of CAP in cancer treatment, primarily focusing on in vivo studies over the past decade. It presents research strategies and discusses the underlying mechanism based on the latest understanding.
Review
Chemistry, Multidisciplinary
Dayun Yan, Alisa Malyavko, Qihui Wang, Li Lin, Jonathan H. Sherman, Michael Keidar
Summary: Cold atmospheric plasma (CAP) is an ionized gas generated by non-equilibrium discharge at atmospheric conditions, showing unique biological impacts in cancer treatment. With potential clinical applications, CAP cancer treatment can utilize both chemical and physical approaches for therapeutic benefits.
APPLIED SCIENCES-BASEL
(2021)
Article
Environmental Sciences
Dongjie Cui, Yue Yin, Hao Sun, Xiaojie Wang, Jie Zhuang, Lin Wang, Ruonan Ma, Zhen Jiao
Summary: Atmospheric pressure cold plasma (APCP) has great potential in improving crop production. This study investigates the regulation mechanism of APCP-generated reactive oxygen and nitrogen species (RONS) on intracellular redox homeostasis and plant growth. The results demonstrate that APCP treatment has a dual effect on Arabidopsis seedling growth, depending on the treatment time. APCP treatment leads to an increase in RONS in the liquid, conductivity, and oxidation reduction potential, and a decrease in pH. APCP treatment also causes an enrichment of intracellular RONS and an increase in malondialdehyde generation. Low-dose APCP treatment enhances intracellular antioxidants while high doses decrease their levels. These results highlight the importance of improved antioxidant capacity induced by moderate APCP-generated RONS in promoting plant growth.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Critical Care Medicine
Keng Siang Lee, Amber Young, Hayley King, A. Toby A. Jenkins, Anna Davies
Summary: This study investigated the variation in burn wound infection (BWI) definitions in systematic reviews (SRs) of burn care interventions and its impact on the identification of effective treatments. The findings revealed heterogeneity in BWI definitions, which affected the drawing of conclusions and limited the validation of effective treatments.
Article
Biophysics
Rachel A. Heylen, Max Branson, Lauren Gwynne, Bethany L. Patenall, Nina Hauschildt, James Urie, June Mercer-Chalmers, Naing T. Thet, Maisem Laabei, A. Toby A. Jenkins
Summary: An optimised biosensor lozenge that can detect impending catheter blockage has been developed, providing early warning and allowing for quicker clinical intervention to reduce morbidity and mortality associated with blockage.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Physics, Applied
Bhagirath Ghimire, Bethany L. Patenall, Endre J. Szili, Nishtha Gaur, Pradeep Lamichhane, Naing T. Thet, Dhruv Trivedi, Andrew Toby A. Jenkins, Robert D. Short
Summary: This study investigates the influence of adding a 2nd ground electrode on the production of hydrogen peroxide (H2O2) in deionised water (DIW) in an argon plasma jet. It is found that the addition of a 2nd ground electrode leads to higher charge accumulation and increased discharge current and dissipated power, resulting in a higher electron temperature and more than twice the production of H2O2. The double ground electrode plasma jet is effective in reducing the growth of common wound pathogens and has low cytotoxicity in skin-like cells. These findings are valuable for optimizing plasma sources for clinical applications.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Review
Chemistry, Multidisciplinary
Wen-Qi Meng, Adam C. Sedgwick, Nahyun Kwon, Mingxue Sun, Kai Xiao, Xiao-Peng He, Eric Anslyn, Tony D. James, Juyoung Yoon
Summary: Chemical warfare agents (CWAs) are targeted toxic chemicals that pose serious threats to public health and global peace. Accurate detection methods for CWAs are essential for security measures. Small molecule fluorescent probes have emerged as attractive tools for CWA detection due to their simplicity, selectivity, and sensitivity, and their ability to be translated into handheld devices.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Nanoscience & Nanotechnology
Nishtha Gaur, Bethany L. Patenall, Bhagirath Ghimire, Naing T. Thet, Jordan E. Gardiner, Krystal E. Le Doare, Gordon Ramage, Bryn Short, Rachel A. Heylen, Craig Williams, Robert D. Short, Toby A. Jenkins
Summary: We introduce a versatile drug-loaded composite hydrogel that can simultaneously deliver a drug and CAP-generated molecules in a tissue target when activated by an argon-based cold atmospheric plasma jet. We demonstrated this concept by encapsulating gentamicin in sodium polyacrylate particles dispersed within a poly(vinyl alcohol) hydrogel matrix. The resulting gentamicin-PAA-PVA composite hydrogel can release gentamicin and effectively eradicate bacteria, including those in planktonic state and biofilm, when activated by CAP. The concept of the composite hydrogel can also be applied to other antimicrobial agents like cetrimide and silver, and activated by any dielectric barrier discharge CAP device.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Emily J. Owen, Rachel A. Heylen, Kyle Stewart, Paul G. Winyard, A. Toby A. Jenkins
Summary: This review discusses the current understanding of the prevention and treatment of Incontinence Associated Dermatitis (IAD). It emphasizes the need for specific preventative measures targeting faecal/urinary irritants, including the use of urease inhibitors. The lack of internationally accepted diagnostic methods for IAD severity is identified, with current diagnosis relying on visual inspection. Non-invasive techniques, such as impedance spectroscopy, could potentially provide objective assessments of skin barrier function and aid in early detection and intervention.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2023)
Review
Dermatology
Bethany L. Patenall, Joanne D. Ridgley, A. Toby A. Jenkins, Amber E. Young
Summary: The prevalence and role of biofilm formation in acute wounds has been rarely investigated. Understanding the presence of biofilm in acute wounds could lead to earlier targeted management, reducing the morbidity and mortality associated with wound infection, improving patient experience and potentially reducing healthcare costs. This study aimed to summarize the evidence for biofilm formation within acute wounds.
JOURNAL OF WOUND CARE
(2023)
Article
Chemistry, Multidisciplinary
Daniel N. Mangel, Gabriel J. Juarez, Stephanie H. Carpenter, Axel Steinbrueck, Vincent M. Lynch, Jian Yang, Adam C. Sedgwick, Aaron Tondreau, Jonathan L. Sessler
Summary: In this study, the use of deferasirox derivatives as lanthanide chelators was reported, and the complexation behavior of these derivatives in solid state and solution was investigated. High selectivity for Lu(III) was observed in competitive precipitation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Nanoscience & Nanotechnology
Jack A. Doolan, Luke S. Alesbrook, Karen Baker, Ian R. Brown, George T. Williams, Kira L. F. Hilton, Makoto Tabata, Penelope J. Wozniakiewicz, Jennifer R. Hiscock, Benjamin T. Goult
Summary: An engineered version of the mechanosensitive protein talin was used to create a hydrogel that can capture and preserve projectiles. This material overcomes limitations in current industry standards and is capable of absorbing high-speed impacts.
NATURE NANOTECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Kira L. F. Hilton, Antonis A. Karamalegkos, Nyasha Allen, Lauren Gwynne, Bree Streather, Lisa J. White, Karen B. Baker, Samantha A. Henry, George T. Williams, Helena J. Shepherd, Mark Shepherd, Charlotte K. Hind, Mark J. Sutton, Toby A. Jenkins, Daniel P. Mulvihill, Jennifer M. A. Tullet, Marina Ezcurra, Jennifer R. Hiscock
Summary: Antimicrobial resistance poses a significant threat to human health. In this study, we investigated the hydrogelation properties and antimicrobial efficacy of fluorescent supramolecular self-associating amphiphiles against both planktonic and biofilm forms of MRSA. The toxicity of these amphiphiles against the multicellular model organism Caenorhabditis elegans was also examined to assess their potential for real-world applications. Material characterization techniques, including optical density plate reader assays, rheometry, and widefield fluorescence microscopy, were used to determine the structure and sol dependence of hydrogel formation.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Kai-Cheng Yan, Jordan E. E. Gardiner, Adam C. C. Sedgwick, Naing Thet, Rachel A. A. Heylen, Tony D. D. James, A. Toby A. Jenkins, Xiao-Peng He
Summary: A new fluorescent probe was developed to determine the NTR activity of different bacterial species under various growth conditions, which can be applied in complex clinical environments with high sensitivity and detection accuracy for both planktonic cultures and biofilms.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Kai-Cheng Yan, Bethany L. L. Patenall, Jordan E. E. Gardiner, Rachel A. A. Heylen, Naing Thet, Xiao-Peng He, Adam C. C. Sedgwick, Tony D. D. James, A. Toby A. Jenkins
Summary: TCF-OTf is a fluorescent probe that can monitor the production of superoxide anions in bacteria. It is responsive to chloramphenicol and heat shock treatment, and can detect the presence of superoxide anions in Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Jack A. Doolan, George T. Williams, Kira L. F. Hilton, Rajas Chaudhari, John S. Fossey, Benjamin T. Goult, Jennifer R. Hiscock
Summary: Antimicrobial resistance is a significant threat to human health, causing more deaths and financial burden than HIV/AIDS or malaria. This review focuses on novel therapeutic strategies, such as self-assembling systems and nanoscale materials, to combat antimicrobial resistance. The mechanisms, advantages, and disadvantages of these systems are discussed, providing guidance for further research and development in this field.
CHEMICAL SOCIETY REVIEWS
(2022)
