Article
Chemistry, Medicinal
Kawaljit Kaur, Jian Xiong, Nishant Sawant, Sanjeev Agarwal, John M. Hickey, David A. Holland, Tarit K. Mukhopadhyay, Joseph R. Brady, Neil C. Dalvie, Mary Kate Tracey, Kerry R. Love, J. Christopher Love, David D. Weis, Sangeeta B. Joshi, David B. Volkin
Summary: This study investigated the interaction between thimerosal and P[4] protein, revealing the mechanism and subsequent effects on the protein's structural integrity. The reversible complexation of ethylmercury with the protein's cysteine residue and its impact on the protein's flexibility and stability were demonstrated and discussed. The findings contribute to understanding the challenges in developing low-cost, multidose formulations for new recombinant protein vaccine candidates.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Immunology
Viviana Parreno, Muqun Bai, Fangning Liu, Jiqiang Jing, Erika Olney, Guohua Li, Ke Wen, Xingdong Yang, Tammy Bui Castellucc, Jacob F. Kocher, Xu Zhou, Lijuan Yuan
Summary: This study evaluates the effect of probiotic Lactobacillus rhamnosus GG (LGG) as a mucosal adjuvant on the immunogenicity and cross-protective efficacy of the Lanzhou live oral trivalent vaccine (TLV) in the pig model of human rotavirus infection. The study demonstrates that LGG enhances immune responses and improves protection against heterotypic HRV, making it a potential adjuvant to improve rotavirus vaccine efficacy.
Article
Biotechnology & Applied Microbiology
Prashant Kumar, Ravi S. Shukla, Ashaben Patel, Swathi R. Pullagurla, Christopher Bird, Oluwadara Ogun, Ozan S. Kumru, Ahd Hamidi, Femke Hoeksema, Christopher Yallop, Julie E. Bines, Sangeeta B. Joshi, David B. Volkin
Summary: The formulation development of the RV3-BB vaccine aims to improve accessibility in low- and middle-income countries by identifying stabilizers and buffering agents to ensure stability in oral delivery conditions and storage. Various pharmaceutical excipients were screened, with promising stabilizers selected to maintain viral infectivity under different stress conditions.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Chemistry, Medicinal
Prashant Kumar, Swathi R. Pullagurla, Ashaben Patel, Ravi S. Shukla, Christopher Bird, Ozan S. Kumru, Ahd Hamidi, Femke Hoeksema, Christopher Yallop, Julie E. Bines, Sangeeta B. Joshi, David B. Volkin
Summary: Two in vitro gastric digestion models were used to evaluate the stability of a live attenuated rotavirus vaccine candidate under conditions mimicking oral delivery in infants, showing key formulation parameters that may affect vaccine stability. Pre-neutralization with infant formula or antacid can provide partial to full protection of the vaccine under rapid inactivation conditions.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Immunology
Rachel M. Burke, Shuman Shih, Chao Agnes Hsiung, Catherine Yen, Baoming Jiang, Umesh D. Parashar, Jacqueline E. Tate, Fang-Tzy Wu, Yhu-Chering Huang
Summary: Although Taiwan did not include rotavirus vaccines in the national immunization schedule, the study found that the vaccines still significantly reduced pediatric hospitalization rates associated with rotavirus.
Article
Immunology
Louisa Pollock, Aisleen Bennett, Khuzwayo C. Jere, Jonathan Mandolo, Queen Dube, Naor Bar-Zeev, Robert S. Heyderman, Nigel A. Cunliffe, Miren Iturriza-Gomara
Summary: Low plasma RV-specific IgA is strongly associated with rotavirus vaccine failure in Malawian infants. This study provides further evidence that RV-specific IgA is a marker of protection, although the question of reduced rotavirus vaccine efficacy in low-income countries remains unclear.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Rachel M. Burke, Jacqueline E. Tate, Umesh D. Parashar
Summary: Rotavirus vaccines have been widely introduced in 106 countries globally, demonstrating effectiveness against severe disease and mortality with a favorable benefit-risk profile. Ongoing research aims to understand geographic disparities in vaccine effectiveness to optimize strategies worldwide.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Rachel M. Burke, Holly C. Groom, Allison L. Naleway, Eric M. Katz, Bianca Salas, Claire P. Mattison, Judy Donald, Laura Tsaknaridis, Christianne Biggs, Michael D. Bowen, Jacqueline E. Tate, Umesh D. Parashar, Mark Schmidt, Aron J. Hall
Summary: The study demonstrates the high effectiveness of rotavirus vaccination in protecting children from mild to severe diseases. By utilizing different case definitions, the study further confirms the effectiveness of rotavirus vaccination in preventing qRT-PCR-defined illnesses.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Roger Glass, Jacqueline E. Tate, Baoming Jiang, Umesh Parashar
Summary: Rotavirus is the leading pathogen causing severe diarrhea in children worldwide, but vaccines have successfully reduced hospitalizations and deaths. However, the effectiveness of these vaccines is lower in low-income countries, prompting the development of new vaccines to address this issue.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Daniel C. Payne, Monica McNeal, Mary Allen Staat, Alexandra M. Piasecki, Allison Cline, Emily DeFranco, Michelle G. Goveia, Umesh D. Parashar, Rachel M. Burke, Ardythe L. Morrow
Summary: Rotavirus-specific antibodies continue to be transferred from US mothers to their offspring in the post-rotavirus vaccine era, despite significant decreases in childhood rotavirus gastroenteritis.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Benjamin L. Hamel, Jenny Patel, Jenna Still, Avni Joshi
Summary: A healthy two-month-old boy developed prolonged non-bloody diarrhea after receiving the rotavirus pentavalent vaccine. Further investigation revealed mild defects in his T-cell immunocompetence and ruled out hereditary forms of primary immunodeficiencies. The source of the rotavirus infection could not be determined, and the caregivers refused further vaccinations due to misconceptions.
Article
Chemistry, Physical
Shisheng Bi, Min Li, Zhihui Liang, Guangle Li, Ge Yu, Jiarui Zhang, Chen Chen, Cheng Yang, Changying Xue, Yi Y. Zuo, Bingbing Sun
Summary: This research improves the suspension stability of Alum through self-assembled rice-shaped aluminum oxyhydroxide nanoadjuvants and explores the mechanism. By adsorbing antigens, the sedimentation of NR-antigen complexes is reduced, and the suspension stability is improved. In addition, the study finds that the aspect ratio of Nanorices is correlated with the intensity of humoral immune responses.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Immunology
Mohammad Ali Savoji, Mohammad Mehdi Adibzadeh Sereshgi, Seyed Mohammad Mahdi Ghahari, Fatemeh Asgarhalvaei, Mehdi Mahdavi
Summary: The Montanide ISA 51VG adjuvant, when formulated with HBsAg, showed superior long-term antibody response induction compared to conventional HBsAg vaccines, suggesting its ability to efficiently trigger both cellular and long-lasting humoral immune responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Microbiology
Tintu Varghese, Shainey Alokit Khakha, Sidhartha Giri, Nayana P. Nair, Manohar Badur, Geeta Gathwala, Sanjeev Chaudhury, Shayam Kaushik, Mrutunjay Dash, Nirmal K. Mohakud, Rajib K. Ray, Prasantajyoti Mohanty, Chethrapilly Purushothaman Girish Kumar, Seshadri Venkatasubramanian, Rashmi Arora, Venkata Raghava Mohan, Jacqueline E. Tate, Umesh D. Parashar, Gagandeep Kang
Summary: After the introduction of the indigenous rotavirus vaccine in India in 2016, surveillance showed a decrease in rotavirus positivity and changes in strain distribution. There was an increase in mixed genotypes observed in the post-vaccination period, highlighting the importance of continuous long-term surveillance.
Article
Forestry
Magdalena Wozniak, Karolina Gromadzka, Patrycja Kwasniewska-Sip, Grzegorz Cofta, Izabela Ratajczak
Summary: Considering environmental degradation, climate changes, and increasing ecological awareness, this study proposed a mixture of chitosan and caffeine as an ecological wood preservative. The results showed that chitosan limited the leaching of caffeine from wood and exhibited antifungal activity.
WOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Business
Manu Sharma, Anil Kumar, Sunil Luthra, Sudhanshu Joshi, Arvind Upadhyay
Summary: Digital supply chain networks and low-carbon practices have an impact on the sustainable performance of manufacturing firms, with the relationship being moderated by environmental dynamism.
BUSINESS STRATEGY AND THE ENVIRONMENT
(2022)
Article
Information Science & Library Science
Manu Sharma, Sunil Luthra, Sudhanshu Joshi, Anil Kumar
Summary: This study examines the challenges of AI implementation in the Public Manufacturing Sector (PMS) of India and proposes a model for decision-makers and managers to develop intelligent AI enabled systems.
GOVERNMENT INFORMATION QUARTERLY
(2022)
Article
Management
Sudhanshu Joshi, Manu Sharma
Summary: The study found that digital technologies, logistics, and infrastructure are the most crucial success factors for managing food security in developing countries during the COVID-19 situation. This supports decision-makers in managing data for demand and supply management, helping them survive and sustain in a disruptive environment. The findings of the study will assist farmers and supply chain partners in managing the smooth flow of food items during a disruptive environment, by changing sourcing, manufacturing, and delivery methods and redesigning internal systems for improvement.
JOURNAL OF GLOBAL OPERATIONS AND STRATEGIC SOURCING
(2022)
Review
Engineering, Electrical & Electronic
Vijai Laxmi, Suhas S. Joshi, Amit Agrawal
Summary: Selective isolation of human blood cells has various applications in disease diagnosis, prognostics, drug discovery, and drug delivery. Microfluidics-based methods offer advantages such as low cost, ease of operation, compact size, and requiring a lower sample volume. This review discusses different microfluidic techniques for isolating white blood cells, including their working mechanisms, microdevice designs, and performance parameters, and also provides a brief overview of the advantages, limitations, and future prospects of these microdevices.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Article
Industrial Relations & Labor
Manu Sharma, Sunil Luthra, Sudhanshu Joshi, Anil Kumar
Summary: This study examines the influence of sustainable human resource management practices and Industry 4.0 technologies on the employability skills of employees. The findings reveal that these practices and technologies directly impact the employability skills of employees, enhancing their skills and competencies and providing them with opportunities for long-term association. This study is significant for the development of the economy and individuals and is also pioneering in the field of human resource management.
INTERNATIONAL JOURNAL OF MANPOWER
(2022)
Article
Green & Sustainable Science & Technology
Manu Sharma, Sunil Luthra, Sudhanshu Joshi, Anil Kumar, Akshat Jain
Summary: The study aims to investigate the impact of green logistics on the adoption of Circular Economy (CE) in the era of Industry 4.0 (I4.0). By implementing green initiatives, the logistics sector shows its strong concern for environmental issues and promotes sustainable logistics and circular practices to address critical issues such as waste generation, resource scarcity, renewable resource use, and climate change. The study examines the relationships between green logistics practices, I4.0 technologies, and CE adoption while also considering the moderating effects of institutional pressure and supply chain flexibility. The findings suggest that firms can enhance CE adoption driven by I4.0 technologies with green logistics practices as a mediator, and the moderating effect of supply chain flexibility is significant while the moderating effect of institutional pressure is insignificant. The study provides valuable insights for managers and contributes to the theoretical understanding of green logistics and CE adoption.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Management
Sudhanshu Joshi, Manu Sharma, Akhilesh Barve
Summary: This study employs the Best Worst Method (BWM) to identify the most critical implementation barriers of IoT and Blockchain technology in Waste Electrical and Electronic Equipment (WEEE) management. The findings reveal that developing a legislative support system, ineffective database management, low understanding of cognitive technologies, and concerns regarding information security and privacy are the key issues in implementing these technologies in closed-loop supply chains.
SUPPLY CHAIN FORUM
(2023)
Article
Green & Sustainable Science & Technology
Manu Sharma, Sudhanshu Joshi, Mukesh Prasad, Shalini Bartwal
Summary: This study proposes a model to examine the critical barriers and suggest strategies for implementing Circular Economy (CE) in the Oil & gas (O&G) industry. The results show that 'knowledge barriers' are the most critical, and the strategies 'Developing collaborative model' and 'Internal research and development, innovation' are the most significant for reducing the barriers.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Green & Sustainable Science & Technology
Sudhanshu Joshi, Manu Sharma, Banu Y. Ekren, Yigit Kazancoglu, Sunil Luthra, Mukesh Prasad
Summary: Food waste reduction and security are major concerns in agri-food supply chains, as more than a third of global food production is wasted or lost due to mismanagement. Resilient food supply chains need to address challenges such as resource scarcity, climate change, and waste generation. This study explores supply chain innovations, using SWARA analysis, to identify the most significant innovations for developing resilient food supply chains. The results highlight the importance of business strategy and technological innovations in bringing resilience to food supply chains.
Article
Business
Manu Sharma, Deepak Kaushal, Sudhanshu Joshi
Summary: Social media has become a major source of information for young users, but it has a severe impact on mental state due to information overload, which is still a concern for researchers. The addiction of Generation Z users to mobile phones/gadgets is increasing with the rise of social media, leading to a complete transformation in their behavioral outcomes. Behavioral issues such as stress, fatigue, fear of missing out, phubbing, and anxiety are on the rise, but the relationship between these issues and information overload has not been sufficiently examined. The study finds that social media platforms need to understand users' compulsive usage, which results in fatigue and anxiety, and government information support plays a positive role in reducing fatigue and anxiety.
JOURNAL OF RETAILING AND CONSUMER SERVICES
(2023)
Review
Multidisciplinary Sciences
Sunil Luthra, Shruti Agrawal, Anil Kumar, Manu Sharma, Sudhanshu Joshi, Jatin Kumar
Summary: Psychological and mental well-being of young adults has been greatly influenced by the COVID-19 pandemic, leading to a global concern. This research study provides an overview of the international scientific studies on the effect of COVID-19 on young adults' psychological well-being. It reveals the top-cited authors, documents, journals, productive countries, keywords, and themes in this area. The United States has contributed the most publications, followed by the United Kingdom and Italy. The study highlights the importance of addressing the psychological health of young adults worldwide.
Article
Health Policy & Services
Sudhanshu Joshi, Manu Sharma
Summary: The widespread use of Blockchain technology (BT) in developing nations is still in its early stages and requires a comprehensive evaluation. The healthcare sector is increasingly in need of digitalization to improve operational efficiency. However, the limited research on BT has hindered its full utilization in the healthcare sector. This study aims to identify the main obstacles to BT adoption in developing nations' public health systems, using a multi-level analysis and hybrid approach. The findings of this study provide guidance and insight for decision-makers on implementation challenges.
Article
Management
Manu Sharma, Sudhanshu Joshi
Summary: This study aims to explore the factors that affect the selection of digital suppliers and evaluate the alternatives for identifying the best supplier that enhances the quality management systems (QMS) for digital supply chains (DSCs). The study reveals that supplier competency is the most significant factor in selecting digital suppliers, and supplier S-8 has been ranked as the best supplier.
Article
Business
Sudhanshu Joshi, Rohit Kumar Singh, Manu Sharma
Summary: This study aims to identify the factors influencing the adoption of sustainable agribusiness practices in India and examines the most pertinent issues. The findings can provide guidance for agribusiness regulators and intermediaries, while contributing to a new understanding of sustainable agribusiness-based issues in India.
GLOBAL BUSINESS REVIEW
(2023)
Article
Business
Rohit Kumar Singh, Sudhanshu Joshi, Manu Sharna
GLOBAL BUSINESS REVIEW
(2023)
