Article
Endocrinology & Metabolism
Chaoran Liu, Pui Yan Wong, Xin Tong, Simon Kwoon-Ho Chow, Vivian Wing-Yin Hung, Wing-Hoi Cheung, Ling Qin, Sheung Wai Law, Ronald Man Yeung Wong
Summary: This study aimed to investigate the roles of fat and muscle in bone structures and the relationship between obesity and sarcopenia in age-related osteoporosis. Data from 400 participants were analyzed to study the correlation between fat, muscle, and bone, and logistic regression analyses were used to explore the risk of osteoporosis. The results showed that low muscle mass and function were harmful to bone health, while obesity had limited protective roles in osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yi Su, Suey S. Y. Yeung, Yu-Ming Chen, Jason C. S. Leung, Timothy C. Y. Kwok
Summary: This study found that the consumption of pro-inflammatory diets was associated with loss of muscle strength and physical function, as well as an increased risk of fractures in older Chinese men. Pro-inflammatory diets had no significant association with muscle-related outcomes but increased the long-term risk of osteoporosis in older Chinese women.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Nutrition & Dietetics
Tatsuro Inoue, Keisuke Maeda, Ayano Nagano, Akio Shimizu, Junko Ueshima, Kenta Murotani, Keisuke Sato, Kazuki Hotta, Shinichiro Morishita, Atsuhiro Tsubaki
Summary: Osteosarcopenia is a common geriatric condition that predominantly affects women, and is associated with increased risks of death, fractures, and falls. However, the causal relationship between osteosarcopenia and these outcomes remains unclear, highlighting the need for further longitudinal and interventional studies to fully understand this syndrome.
Article
Geriatrics & Gerontology
Yi-zhen Nie, Zhao-qi Yan, Hui Yin, Ling-han Shan, Jia-hui Wang, Qun-hong Wu
Summary: This study investigated the associations between osteosarcopenic obesity (OSO) and inflammation indices derived from complete blood cell count. The results showed that higher values of SIRI, AISI, NLR, and PLR were associated with increased likelihood of multiple disorders with abnormal body composition in older adults, while lower LMR values were inversely correlated with these conditions.
Review
Nutrition & Dietetics
Maria Carmen Andreo-Lopez, Victoria Contreras-Bolivar, Beatriz Garcia-Fontana, Cristina Garcia-Fontana, Manuel Munoz-Torres
Summary: The Mediterranean diet has potential benefits for bone and muscle health, protecting against deterioration. Adhering to this diet can improve bone mineral density, muscle mass, physical function, and prevent osteoporosis and sarcopenia. However, the relationship between the Mediterranean diet, strength, and fracture risk remains controversial.
Review
Biochemistry & Molecular Biology
Marie-Eva Pickering
Summary: Magnesium plays a crucial role in healthy aging of the cardiovascular-muscle-bone triad. Low levels and intake of magnesium are common in aging population and associated with poor outcomes. Magnesium supplementation may be beneficial but more clinical trials are needed to optimize treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Do-Youn Lee, Sunghoon Shin
Summary: Sarcopenia is significantly associated with bone disorders, such as osteopenia and osteoporosis, especially in older Korean men.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Xingli Liu, Cunwen Ma, Shiping Wang, Zhengrong Liang, Juntao Yang, Jun Zhou, Yi Shu, Zhengying He, Jilong Zong, Lizhi Wu, Peiqian Peng, Yi Su, Meng Gao, Kaiming Shen, Hong Zhao, Jilu Ruan, Shaoxuan Ji, Yunhui Yang, Taisong Tang, Zongfa Yang, Guangyin Luo, Meng Zeng, Weiwan Zhang, Bo He, Xiaoguang Cheng, Gang Wang, Ling Wang, Liang Lyu
Summary: This study aims to explore the effects of high-altitude environments on the skeletal muscle system, recruiting 4000 participants aged over 50 to compare differences in bones and muscles at different altitudes. The study includes a baseline assessment and a 5-year follow-up to evaluate factors influencing muscle size, density, and function, aiming to establish clinical diagnostic criteria for the muscular system in high-altitude environments.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ting Xiang, Ping Fu, Li Zhou
Summary: The aim of this study was to explore the prevalence of sarcopenia and its association with osteoporosis and to determine its impact on survival risk in hemodialysis patients. The study found a significant association between muscle mass and strength with bone density in hemodialysis patients, and those with osteosarcopenia had a higher mortality rate.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Darren G. Candow, Scott C. Forbes, Ben Kirk, Gustavo Duque
Summary: Sarcopenia, characterized by age-related reduction in muscle mass, strength, and physical performance, is associated with various age-related health conditions. Creatine supplementation, especially when combined with resistance training, shows promising effects on muscle, bone, and fat mass, as well as strength and physical performance in healthy older adults. However, more research is needed on the efficacy of creatine supplementation in older adults with specific conditions like osteoporosis and sarcopenic obesity.
Article
Endocrinology & Metabolism
Mozhgan Ahmadinezhad, Mohammad Ali Mansournia, Noushin Fahimfar, Gita Shafiee, Iraj Nabipour, Mahnaz Sanjari, Kazem Khalagi, Mohammad Javad Mansourzadeh, Bagher Larijani, Afshin Ostovar
Summary: Osteosarcopenic obesity is a new syndrome that affects the elderly, and this study found a high prevalence of this condition among the elderly in Iran.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Medicine, General & Internal
Yoshiaki Taniguchi, Hyuma Makizako, Yuki Nakai, Yuto Kiuchi, Shoma Akaida, Mana Tateishi, Toshihiko Takenaka, Takuro Kubozono, Mitsuru Ohishi
Summary: This study investigated the association between the ACTN3 genotype and bone and muscle mass loss in community-dwelling adults aged 60 years and older. The results showed that the XX genotype of ACTN3 was significantly associated with a higher rate of combined bone and muscle mass loss.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Celia L. Gregson, Tafadzwa Madanhire, Andrea Rehman, Rashida A. Ferrand, Anne R. Cappola, Steven Tollman, Tshepiso Mokoena, Lisa K. Micklesfield, Alisha N. Wade, June Fabian
Summary: The study found that osteoporosis is more common than sarcopenia among aging individuals in rural South Africa, with older women living with HIV experiencing greater bone loss. This raises concerns over future fracture risk in Southern Africa, highlighting the importance of routine bone health assessments in HIV clinics, especially for aging women.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Cell Biology
Xue-Ying Ma, Hui-Min Liu, Wan-Qiang Lv, Chuan Qiu, Hong-Mei Xiao, Hong-Wen Deng
Summary: Both sarcopenia and osteoporosis are common geriatric diseases. This study used a bidirectional two-sample Mendelian randomization (MR) analysis to examine the potential causal relationship between sarcopenia-related traits and osteoporosis. The results showed a positive causal association between bone mineral density (BMD) and hand grip strength and fat-free mass, suggesting that osteoporosis may be a risk factor for sarcopenia-related traits.
Article
Orthopedics
Hanhao Dai, Wu Zheng, Jun Luo, Guoyu Yu, Chao Song, Yijing Wu, Jie Xu
Summary: Differentially expressed genes in senescent SCs were enriched in muscle cell differentiation, affecting their myogenic potential. Senescent BMSC-EVs impaired the myogenic potential of SCs, while blocking CD81 could alleviate this damage.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)