Article
Agriculture, Dairy & Animal Science
Paloma Helena Sanches da Silva, Carlos Eduardo Bastos Lopes, Larissa Bueno Stallmach, Lucas de Oliveira Ferreira, Pedro Antonio Bronhara Pimentel, Antonio Giuliano, Patricia Maria Coletto Freitas, Rodrigo dos Santos Horta
Summary: This study investigates the efficacy of different sealing methods after partial lobectomy in dogs and concludes that manual sutures and synthetic glue sealants are effective in preventing air leakage.
Article
Pharmacology & Pharmacy
Luis Fernandez-Vega-Cueto, Mairobi Persinal-Medina, Natalia Vazquez, Manuel Chacon, Belen Alfonso-Bartolozzi, Sergio Alonso-Alonso, Teresa Sanchez, Silvia Berisa-Prado, Laura Maria Martinez-Lopez, Jesus Merayo-Lloves, Alvaro Meana
Summary: The study proposes a method to prepare autologous bio-based fibrin glue for ophthalmic surgery. The adhesive strength of FG increased with fibrinogen concentration, and FG2 and FG3 showed successful results in conjunctival autografts with equivalent properties compared to commercial FG and reduced inflammation.
Article
Immunology
Luciana P. F. Abbade, Silvia Regina Catharino Sartori Barraviera, Maria Regina Cavariani Silvares, Ana Beatriz B. de C. O. Lima, Gabriela R. Haddad, Marcia A. N. Gatti, Natalia Bronzatto Medolago, Marcia Tonin Rigotto Carneiro, Lucilene Delazari dos Santos, Rui Seabra Ferreira, Benedito Barraviera
Summary: The study evaluated the safety and efficacy of HFS in treating chronic venous ulcers, showing promising results in healing ulcers. However, further multicentric phase III clinical trials are needed to confirm these findings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Chemical
Vijai Laxmi, Suhas S. Joshi, Amit Agrawal
Summary: The study successfully developed a microdevice using microfluidic technology to efficiently isolate platelet-poor plasma with a purity of 94.7%, without affecting the shape and size of platelets. The microdevice is compact, easy to fabricate, reliable, and suitable for rapid and convenient point-of-care applications.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Lisha Yu, Zhaodi Liu, Zongrui Tong, Yihang Ding, Zhefeng Qian, Weilin Wang, Zhengwei Mao, Yuan Ding
Summary: A sequential crosslinking fibrin glue (SCFG) is developed, which forms the initial network within 2 seconds and locks the gelatin methacryloyl precursor for construction of the second network to enhance wet adhesion and durability for tissues. SCFG shows ultrafast gelation, strong adhesion and durability, excellent compatibility, and easy manufacture, making it a promising hemostatic adhesive.
Review
Polymer Science
Carlos Henrique Bertoni Reis, Daniela Vieira Buchaim, Adriana de Cassia Ortiz, Simone Ortiz Moura Fideles, Jefferson Aparecido Dias, Maria Angelica Miglino, Daniel de Bortoli Teixeira, Eliana de Souza Bastos Mazuqueli Pereira, Marcelo Rodrigues da Cunha, Rogerio Leone Buchaim
Summary: Fibrin, a biopolymer derived from proteins involved in blood clotting, has various applications in the health area. Its combination with photobiomodulation (PBM) can stimulate cell activity, angiogenesis, osteoblast activation, and collagen synthesis.
Article
Surgery
Ahmed Fawzy, M. Ashraf Balbaa, Ahmed Gaber
Summary: The study showed that using fibrin glue in inguinal lymph node dissection significantly reduced the incidence of seroma formation, total amount of serous fluid, time to remove drains, and hospital stay. However, there were no significant differences between the two groups in occurrences of hematoma, infection or superficial skin edge necrosis. Future studies need to standardize the definition of seroma and determine the optimal dosage and technique of fibrin glue in ILND.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Multidisciplinary Sciences
Yuuki Shirai, Junko Okano, Takahiko Nakagawa, Miwako Katagi, Yuki Nakae, Atsuhiro Arakawa, Shinya Koshinuma, Gaku Yamamoto, Hideto Kojima
Summary: This article investigates the regenerating effect of gelatin sponges as scaffolds in deep wounds with periosteal defects in rats. The study demonstrates that the microenvironment provided by the gelatin sponges enables bone marrow-derived cells to form a vascular niche, leading to the regeneration of periosteum, skin, and skin appendages. These findings emphasize the importance of vascular niche formation in the regeneration of heterogeneous tissues in deep wounds.
SCIENTIFIC REPORTS
(2022)
Article
Materials Science, Biomaterials
Yifan Zhang, Xiaojie Li, Guanghang Bai, Wei Wei, Xiaoya Liu
Summary: By developing a dynamic thiol-aldehyde crosslinked solvent-free adhesive based on hyperbranched polymer, a bioadhesive with strong bonding performance, self-healing, and thermo-reversible bonding properties has been engineered, suitable for clinical application.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
David Yurui Lim, Mark Wang, Kabilan Chokkappan, Kristen Alexa Lee, Sum Leong, Keng Sin Ng, Chow Wei Too
Summary: Percutaneous glue embolization has shown good efficacy and safety in the treatment of bronchopleural fistulae and alveolar-pleural fistulae associated with persistent air leak.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Review
Cell Biology
Adriana de Cassia Ortiz, Simone Ortiz Moura Fideles, Karina Torres Pomini, Marcia Zilioli Bellini, Eliana de Souza Bastos Mazuqueli Pereira, Carlos Henrique Bertoni Reis, Joao Paulo Galletti Pilon, Miguel Angelo de Marchi, Beatriz Flavia de Moraes Trazzi, Willian Saranholi da Silva, Marcelo Rodrigues da Cunha, Daniela Vieira Buchaim, Rogerio Leone Buchaim
Summary: Cell-based therapy, specifically combining MSCs with fibrin glue, shows potential for nerve regeneration and functional recovery.
Article
Pharmacology & Pharmacy
Jiafu Mu, Jiahe Wu, Jian Cao, Teng Ma, Liming Li, Shiqing Feng, Jianqing Gao
Summary: This study evaluates an emergency cell-free treatment using mesenchymal stem cell-derived exosomes for traumatic spinal cord injury, which has been shown to comprehensively mitigate the inhibitory lesion microenvironment, providing a promising strategy for effective emergency treatment of central nervous system trauma.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Orthopedics
Arya Amirhekmat, Wendy E. Brown, Evelia Y. Salinas, Jerry C. Hu, Kyriacos A. Athanasiou, Dean Wang
Summary: The mechanical properties of fibrin sealants for intra-articular surgical fixation of cartilage fragments and implants were investigated in this study. The adhesive properties of the sealants were not affected by the type or number of applications, but were found to be less than desired for cartilage repair implants. These findings highlight the need for improved cartilage-specific adhesives for cartilage repair applications.
Article
Medicine, General & Internal
Wei Wei Dayna Yong, Liang Shen, Ray Manotosh, Wee Tien Anna Marie Tan, Hui Chen Charmaine Chai
Summary: This study compared the recurrence rate and outcomes of double-headed pterygia using fibrin glue versus suture closure of conjunctival autograft. The results showed a lower recurrence rate in the fibrin glue group, shorter operation duration time, and better postoperative visual outcomes.
ANNALS OF MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Beatrice Orlandini, Tommaso Schepis, Andrea Tringali, Pietro Familiari, Ivo Boskoski, Federica Borrelli de Andreis, Vincenzo Perri, Guido Costamagna
Summary: This study retrospectively analyzed data from patients with refractory post-ES and post-EP bleeding, showing that endoscopic FG injection is effective in treating most patients, with a few requiring other invasive treatment modalities to control bleeding. Further studies are needed to confirm these preliminary findings.
DIGESTIVE ENDOSCOPY
(2021)
Article
Multidisciplinary Sciences
Manisha Singh, Claudia E. Varela, William Whyte, Markus A. Horvath, Nigel C. S. Tan, Chee Bing Ong, Patric Liang, Marc L. Schermerhorn, Ellen T. Roche, Terry W. J. Steele
Summary: Voltage-activated tissue adhesives show promise in endoluminal repair, with the potential for diverse applications including treatment of various lumen defects. The ePATCH/CATRE platform demonstrates effective sealing of defects and minimal disruption to electrical signals.
Article
Nanoscience & Nanotechnology
Ivan Djordjevic, Gautama Wicaksono, Ivan Solic, Juhi Singh, Tanvi Sushil Kaku, Sierin Lim, Elwin Wei Jian Ang, Lluis Blancafort, Terry W. J. Steele
Summary: Carbene-based macromolecules offer a new approach to biomaterials with stimuli-sensitive properties, using visible light to activate diazirine-to-carbene cross-linking without UVA limitations. Through the use of photocatalysts and light doses, the speed and quality of the transition from liquid to biorubber can be controlled. Experimental results with CaproGlu demonstrate strong adhesion and low toxicity, showing potential for various biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Biomaterials
Nigel C. S. Tan, Ivan Djordjevic, Jamie Ann Malley, Ailyn L. Q. Kwang, Syed Ikhwan, Ivan Solic, Juhi Singh, Gautama Wicaksono, Sierin Lim, Terry W. J. Steele
Summary: This study explores a novel class of carbene-based biomaterials that are stable under indoor lighting but rapidly activated under direct sunlight. Adhesion strength can be controlled and crosslinking achieved in a short time through activation by natural sunlight.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Richa Chaudhary, Varun Chaudhary, Yoshiyuki Suda, Raju V. Ramanujan, Terry W. J. Steele
Summary: Magnetocuring refers to the curing of epoxy using controlled heating of magnetic nanoparticles, achieving remote, wireless curing without resin overheating. By tuning CNP composition and adding carbon allotropes, SAR can be improved, while electromagnetic shielding, resin conductivity, and viscosity can regulate heat generation and dissipation. Nanocoils and nanotubes of CA enhance heating profiles of epoxy thermosets, leading to activation of magnetocured composites within 180 s under optimized conditions.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Electrochemistry
Adriano Ambrosi, Manisha Singh, Richard D. Webster, Terry W. J. Steele
Summary: There is a growing interest in developing innovative adhesive materials with stimuli-responsive mechanical properties. Electrocuring adhesives, such as Voltaglue, utilize electric field stimuli to initiate and propagate polymerization reactions, allowing for control over viscoelastic and adhesive properties through voltage and coulomb manipulation. This correlation between diazirine reduction and mechanical properties enables precise control over adhesive properties, with potential applications in electromagnetic biomaterials and additive manufacturing.
Article
Materials Science, Biomaterials
Gautama Wicaksono, Felicia Toni, Leonard Wei Feng Tok, Jeanette Jun Ting Thng, Ivan Solic, Manisha Singh, Ivan Djordjevic, Francesco Baino, Terry W. J. Steele
Summary: A method for bone fixation using transparent biopolymers anchored in place via light-activated biocomposites has been proposed in this study. This method enhances the stiffness and pullout strength of the biocomposite matrix by using UV light as a guide for activation. The relationship between UV joules dose, pin diameter, biocomposite additives and properties such as apparent viscosity, shear modulus, spatiotemporal pin curing, and lap-shear adhesion has been assessed, providing a new potential strategy for improving bone fracture fixation.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Chemistry, Applied
Juhi Singh, Nigel C. S. Tan, Usha Rani Mahadevaswamy, Nattharee Chanchareonsook, Terry W. J. Steele, Sierin Lim
Summary: A drug delivery platform with extended soft tissue adhesion capability of up to 7 days is proposed for on-site management of oral wounds, utilizing bacterial cellulose and photoactivated carbene-based bioadhesives. The composite exhibits adhesion strength ranging from 7 to 17 kPa and duration exceeding 48 hours in wet conditions, surpassing traditional mucoadhesives based on hydrophilic macromolecules. This study marks the first evaluation of BC composites for mucoadhesive treatments in the buccal cavity.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Biomaterials
Juhi Singh, Terry W. J. Steele, Sierin Lim
Summary: The study introduces aqueous composites made of bacterial cellulose and photoactive bioadhesives for soft epithelial surfaces. These composites crosslink upon photocuring, transitioning from viscous to elastic adhesive hydrogels with tunable adhesion strength. The results suggest the potential application of bacterial cellulose hydrogel systems for mucosal wound treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Applied
Animesh Ghosh, Priyavadana Meyyappan, Terry W. J. Steele
Summary: This study investigates electronic initiation of diacrylate resins through voltage activation. The results show that cathodic activation can induce a liquid to solid transition in acrylate resins, while anodic activation fails to initiate gelation. Voltage activation of acrylate resins is feasible, but further improvements in increasing crosslinking kinetics are needed before industrial applicability.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Polymer Science
Ivan Djordjevic, Gautama Wicaksono, Juhi Singh, Manisha Singh, Elizabeth G. Ellis, Maher A. Alraddadi, Andrew P. Dove, Terry W. J. Steele
Summary: In this study, thiol/ene-based resorbable elastomers were combined with a carbene bioadhesive to create a dual crosslinked, three-component hybrid network. The resulting hybrid bioadhesive displayed both tunable dynamic moduli and shear adhesion strength, making it a promising candidate for various biomedical applications.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Elizabeth Ellis, Ivan Djordjevic, Muhammad Naziruddin Bin Mohd Ali, Terry W. J. Steele
Summary: Light-activated carbenes provide a unique method of non-specific covalent bond formation needed in bioadhesives and rapid gelation. The behavior of carbene-based bioadhesives in the presence of various liquid additives containing reactive functional groups has been investigated. The results show that different additives have different effects on material properties, such as maintaining storage modulus, reducing viscosity, accelerating hydrolysis, increasing hydrophilicity, and enhancing dynamic modulus.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Polymer Science
Animesh Ghosh, Konrad Kozlowski, Terry W. J. Steele
Summary: The development of bioadhesives with integrated properties that can be electronically activated for laparoscopic and robotic surgeries is an unmet clinical need. A new voltage-activated adhesive based on lipoic acid has been evaluated, showing improved gelation kinetics and adhesive properties for wet tissue adhesion. The synthetic metal lipoates have comparable adhesion strength to fibrin sealants without viral or ethical risks.
Article
Materials Science, Multidisciplinary
Animesh Ghosh, Juhi Singh, Sierin Lim, Terry W. J. Steele
Summary: Bioadhesives containing catechol crosslinkers have broad application on different substrates. However, the use of oxidative chemicals in catechol's adhesion chemistry can be harmful to organic substrates. In this study, a water-activated adhesive with inherent antibacterial properties was developed by grafting catechol groups onto branched polyethylenimine (PEI-DBA20). The adhesive undergoes curing in the presence of water, facilitated by the close proximity of catechol/Schiff base functional groups.
MATERIALS TODAY ADVANCES
(2023)
Article
Materials Science, Biomaterials
Juhi Singh, Terry W. J. Steele, Sierin Lim
Summary: In this study, dry and shelf-stable cellulose patches were designed to address the challenges of managing diseases in the wet oral cavity environment. These patches can release therapeutic drugs continuously and offer flexible application methods.
BIOMATERIALS ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
Richa Chaudhary, Varun Chaudhary, Raju Ramanujan, Terry W. J. Steele
Summary: The rheological behavior of polymer magnetic composites in the presence of an alternating magnetic field (AMF) was investigated using a custom-made magneto-rheometer. The study found that magnetoadhesive composites reached the gelation point quickly after AMF exposure and exhibited high shear modulus at low strains. The crosslinking kinetics were strongly influenced by factors such as nanoparticle loading, thermal conductivity, and initiation temperature. The study also determined the optimum process parameters for magnetic field processing of polymer magnetic composites using a high-throughput approach.
MATERIALS ADVANCES
(2022)