Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 11, Pages 3089-3095Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00700
Keywords
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Funding
- National Key Research and Development Program of China [2018YFC1406705]
- National Natural Science Foundation of China [41606173, 81741152]
- International Postdoctoral Exchange Fellowship Program [20170092]
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The Arctic fungus Eutypella sp. D-1, previously found to produce a variety of cytotoxic cyclopropyl-fused and cyclobutyl-fused pimarane diterpenoids when grown in the defined medium, was induced to produce unusual metabolites by growing on solid rice medium. A chemical investigation on the rice medium extract led to the isolation of four new meroterpenoids, eutypellacytosporins A-D (1-4), along with the known biogenetically related compound cytosporin D (5). The structures of the new compounds were elucidated by their detailed spectroscopic analysis and modified Mosher's method. Compounds 1-4 may be formed by the 12,32-ester linkage of two moieties, cytosporin D (5) and decipienolide A or B. All isolated compounds, except 5, showed weak cytotoxicity against DU145, SW1990, Huh7, and PANC-1 cell lines with IC50 values ranging from 4.9 to 17.1 mu M.
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