Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1195, Issue -, Pages 689-701Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2019.06.018
Keywords
1,5-Benzodiazepin-2-one; 1,2,3-Triazole; Microwave irradiation; Click chemistry; Antimicrobial activity; Antioxidant activity
Categories
Funding
- DGRS (Direction Generale de la Recherche Scientifique) of the Tunisian Ministry of Higher Education and Scientific Research
Ask authors/readers for more resources
Large series of novel N-bis-1,2,3-triazolo-linked-1,5-benzodiazepin-2-ones (BZD) have been synthesized under microwave irradiation through a Cu(I)-catalyzed double 1,3-dipolar alkyne-azide coupling reaction. This process is of considerable synthetic advantages in terms of time saving and remarkable yields. The chemical structures of the isolated compounds have been elucidated on the basis of extensive spectroscopic methods including 1D & 2D NMR, IR and HRMS. All the synthesized compounds have been evaluated for their antimicrobial and antioxidant activities. In vitro antimicrobial environment, almost all of compounds have shown an interesting activity. Among the dimers of 1,5-benzodiazepine-1,2,3-triazole compounds tested, the results revealed that the potent antibacterial was recorded to compounds 3g,l for Gram-positive (within MIC = 31.25 and 125 mu g/mL), and 3h,k for Gram-negative (within MIC = 31.25 and 125 mu g/mL). Besides, the results demonstrate that compounds 3h,k have demonstrated the strongest potential against all the tested fungus (within MIC = 62.5 and 125 mu g/mL). The antioxidant evaluation indicated that most compounds exhibited a moderate to good biological activity. (C) 2019 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available