Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 20, Pages 4895-4898Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.09.023
Keywords
Melodinine V; Bisindole; Inhibited cell proliferation; Cell cycle arrest; Cellular apoptosis; HT-29 cells
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Funding
- National Natural Science Foundation of China - China [81225024, 31500292]
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Melodinine V (1) with a vincanol-eburenine skeleton, was isolated from Melodinus henryi. The structure was elucidated by extensive spectroscopic methods and further confirmed by the single crystal X-ray diffraction analysis. Melodinine V showed selective cytotoxic activities against human colon cancer cell line HT-29 and inhibited cell proliferation in a concentration-dependent manner. It induced cell cycle arrest at G1 phase and cellular apoptosis by increasing histone-associated DNA fragmentation in the treated HT-29 cells. (C) 2016 Elsevier Ltd. All rights reserved.
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