Article
Chemistry, Multidisciplinary
Shanshan Chang, Yajun Luo, Ning He, Xinyue Huang, Mingxu Chen, Lijie Yuan, Yunying Xie
Summary: Two new lipolanthines, Nocaviogua A and B, were isolated from the mutualistic actinomycete Nocardia sp. XZ19_369 obtained from sea buckthorn nodules in Tibet. Their structures were determined using extensive analyses and their configurations were elucidated for the first time in this lipolanthine family. Nocaviogua A exhibited weak cytotoxicity against human cancer cells. This study provides valuable insights for further investigations on this emerging class of lipolanthines.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
You-Ying Chen, Lo-Yun Chen, Po-Jen Chen, Mohamed El-Shazly, Bo-Rong Peng, Yu-Cheng Chen, Chun-Han Su, Jui-Hsin Su, Ping-Jyun Sung, Pei-Tzu Yen, Lung-Shuo Wang, Kuei-Hung Lai
Summary: This study identified anti-leukemic metabolites from marine-derived bacteria, with the fermentation broth extract of Streptomyces sp. LY1209 showing potent anti-proliferative effects against acute lymphoblastic leukemia cells. The major constituents were staurosporine and a series of diketopiperazines (DKPs), including a novel DKP, which were identified for the first time in nature.
Article
Biotechnology & Applied Microbiology
Ke-Tao Zhang, Zhi-Pu Huang, Xiao-Rong Xu, Si-Heng Li, Yu-Xiao Xu, Qing Zhao, Xiao-Mei Zhang
Summary: Two new diketopiperazines, samsoniellain A (1) and samsoniellain B (2), were obtained from the Cordyceps fungus Samsoniella sp. XY4. Their structures were determined by various spectroscopic techniques. The antimicrobial activity results showed that one of the compounds exhibited weak bacteriostatic activities against certain strains.
JOURNAL OF ANTIBIOTICS
(2023)
Article
Chemistry, Organic
Hadi Gholami, Brandon M. Cornali
Summary: A novel method for synthesizing spirocyclic compounds with a diketopiperazine motif has been reported, achieving high diastereoselectivity through an acid-catalyzed reaction. The generality and applicability of this method in accessing chemically diverse DKP-containing structures have been demonstrated.
Article
Biochemistry & Molecular Biology
Jian Cai, Chunmei Chen, Yanhui Tan, Weihao Chen, Xiaowei Luo, Lianxiang Luo, Bin Yang, Yonghong Liu, Xuefeng Zhou
Summary: In this study, ten polyketide derivatives and five known diketopiperazines were isolated from a mangrove-sediment-derived fungus. Compound 3 showed weak cytotoxicity against the A549 cell line, while compound 2 exhibited weak antibacterial activity against MRSA. In silico molecular docking indicated that compounds 1, 11-14 showed significant protein/ligand-binding effects to the NF-kappa B p65 protein.
Article
Biochemistry & Molecular Biology
Jorge R. Virues-Segovia, Fernando Reyes, Sandra Ruiz, Jesus Martin, Ignacio Fernandez-Pastor, Carlos Justicia, Mercedes de la Cruz, Caridad Diaz, Thomas A. Mackenzie, Olga Genilloud, Ignacio Gonzalez, Jose R. Tormo
Summary: The scientific community is turning to nature to find new antibiotics against emerging multidrug-resistant superbugs. Researchers isolated and identified 108 strains of halophilic actinomyces from saline substrates in Spain. Through fermentation and assessment of antibacterial and antifungal properties, they discovered two novel antibiotic compounds and confirmed the antifungal activity of a known metabolite. The study provides valuable insights for the development of new anti-infective agents.
Article
Chemistry, Medicinal
Shuang Chen, Da-shan Zhang, Jin-hui Wang
Summary: Chemical investigation of secondary metabolites from the deep-sea-derived Alcanivorax sp. SHA4 resulted in the identification of a new compound 1, which is the acetyl derivative of antimycic acid (2), along with 11 known compounds (2-12). The structures of these compounds were determined using extensive nuclear magnetic resonance and mass spectrometry spectroscopic analyses, and the absolute configuration of compound 1 was determined using Marfey's method. Bioactivity assays revealed that compounds 1 and 2 exhibited significant neuroprotective properties against glutamate-induced PC12 cell death at concentrations ranging from 0.02 to 0.31 μM.
NATURAL PRODUCT COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Jintong Song, Ke Xu, Chunyu Liu, Tian Wang, Xiaoyi Luan, Lihua Zhu, Zhaojun Chu, Xiaojie Fu, Wenqiang Chang, Xiaoning Wang, Hongxiang Lou
Summary: Fourteen undescribed compounds, including five 2,5-diarylcyclopentenones xylariaones A1-B2, seven a-pyrone derivatives xylaripyones A G, one.-pyrone derivative xylaripyone H, one diketopiperazine cyclo-(L-Leu-N=ethyl-L-Glu), and two known diketopiperazines, were isolated from cultures of the endophytic fungus Xylaria sp., which was separated from Cudrania tricuspidata Bureau ex Lavall ' ee. Their structures were determined by analysing extensive spectroscopic data (HRESIMS and NMR) and electronic circular dichroism (ECD) calculations. Furthermore, these compounds were evaluated for potential antiproliferative activity against the human tumour cell lines PC3 and A549, and the results showed that xylaripyone D exhibited moderate inhibitory activity against the proliferation of PC3 cell lines with an IC50 value of 14.75 μM. Meanwhile, xylariaone A3 and xylaripyone F displayed weak inhibitory effects on NO production in RAW 264.7 murine macrophages with IC50 values of 49.76 and 69.68 μM, respectively.
Article
Chemistry, Organic
Shingo Takiguchi, Yuki Hirota-Takahata, Takahide Nishi
Summary: In this study, the Marfey's method was used to determine the configuration of β-OH Dab in ogipeptin A, confirming the 2:1 ratio of (2S,3S) to (2S,3R) β-OH Dab isomers in ogipeptins.
TETRAHEDRON LETTERS
(2022)
Article
Plant Sciences
Dulamini Ekanayake, Bruno Perlatti, Dale C. Swenson, Kadri Poldmaa, Gerald F. Bills, James B. Gloer
Summary: The genus Sphaerostilbella includes fungi that colonize basidiomata of wood-inhabiting fungi, including important forest pathogens. Studies of a isolate collected on the foothills of Himalayas, closely related to S. broomeana isolates from Europe, led to the identification of a new cyclic octapeptide along with related analogues and dioxopiperazines.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Forestry
Robson Luis Silva de Medeiros, Rinaldo Cesar de Paula, Joao Vitor Oliveira de Souza, Joao Pedro Peixoto Fernandes
Summary: This study evaluated the effects of temperature, water and saline stress on Z. tuberculosa seed germination and water stress on seedling growth. The results showed that a temperature of 25 and 30 degrees Celsius increased the physiological potential of the seeds, while water and saline stresses decreased germination and vigor. In the greenhouse, moisture levels below 50% of field capacity compromised seedling physiological and morphological parameters.
JOURNAL OF FORESTRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qi Hong, Miao-Miao Guo, Jin Yang, Xing Wei, Li Liao, Xiu-Juan Xin, Di Zhang, Fa-Liang An
Summary: Four previously undescribed diketopiperazine-type alkaloids and three new 4-quinazolinone alkaloids were isolated and characterized from a marine-derived fungus. Compound 6 and 14 showed moderate cytotoxic activity against HeLa cells.
Article
Chemistry, Physical
Christian H. Schiwek, Christian Jandl, Thorsten Bach
Summary: The direct hydrogenation of aromatic systems is an important method for obtaining saturated carbo- and heterocycles. This study reports a modular approach to efficiently and selectively hydrogenate 2,5-DKPs, resulting in high yields of saturated pentacyclic 2,5-DKPs.
Article
Biochemistry & Molecular Biology
Annabel C. Murphy, Matthew Corney, Rita E. Monson, Miguel A. Matilla, George P. C. Salmond, Finian J. Leeper
Summary: Dickeya solani, a pathogenic bacterium, produces a potent anti-fungal compound called solanimycin. The biosynthetic gene cluster responsible for its synthesis has been identified, and LC-MS2 analysis revealed the presence of two main compounds, solanimycin A and B. The structure of solanimycin A was found to be a hexapeptide and it is the first reported example of a nonribosomal peptide (NRPS) module acting iteratively. This unique pathway makes solanimycin biosynthesis distinct from other NRPSs.
ACS CHEMICAL BIOLOGY
(2023)
Review
Chemistry, Medicinal
Zhiqiang Song, Yage Hou, Qingrong Yang, Xinpeng Li, Shaohua Wu
Summary: Diketopiperazines are compounds with extensive biological functions and a stable six-membered ring, making them important for drug discovery. Marine organisms have been a key source for discovering diketopiperazine derivatives, with an increasing number of bioactive diketopiperazines being found in recent years. This review focuses on new 2,5-diketopiperazines derived from marine organisms, evaluating their chemical structures, biological activities, and sources for potential further study in drug discovery.
Article
Engineering, Electrical & Electronic
Oh-Kee Kwon, Chul-Wook Lee, Ki-Soo Kim
Summary: We present an electroabsorption modulator (EAM)-integrated distributed Bragg reflector laser diode (DBR-LD) with high data rate capabilities and wide wavelength tuning. The chip features low threshold current, large tuning range, and high static extinction ratio. Clear eye openings were observed at different data rates, demonstrating excellent modulation performance.
Article
Dentistry, Oral Surgery & Medicine
Yuseung Yi, Seong-Joo Heo, Jai-Young Koak, Seong-Kyun Kim
Summary: The study retrospectively analyzed the success of implant-assisted removable partial dentures (IARPDs) in three strategic positions in distal extension areas of Kennedy Class I and II arches. The results showed that the treatment type did not significantly affect the success rate of IARPDs, but the strategic position of the implants was associated with success rate.
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
(2023)
Article
Engineering, Biomedical
Jae Hee Lee, Yuri Ahn, Han Eol Lee, You Na Jang, A. Yeon Park, Shinho Kim, Young Hoon Jung, Sang Hyun Sung, Jung Ho Shin, Seung Hyung Lee, Sang Hyun Park, Ki Soo Kim, Min Seok Jang, Beom Joon Kim, Sang Ho Oh, Keon Jae Lee
Summary: A wearable surface-lighting micro-LED (S mu LED) photostimulator is reported for skin care and cosmetic applications. The S mu LEDs maximize photostimulation effectiveness on the skin surface by uniform irradiation, high flexibility, and thermal stability, and its anti-melanogenic effect is confirmed through experiments.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Health Care Sciences & Services
Sung Shin Kim, Jun Sik Park, Dongil Choi, Yumi Shin, Kyeyeob Jo, Youngkyung Kim, Sun Ok Kim, Hyosun Kweon, Anna Lee, Young-Hyeon Bae
Summary: This study aimed to identify the optimal posture for the prevention of pressure ulcers by analyzing pressure changes applied to the pelvic region. It was found that lateral rotation combined with changes in the angles of the trunk and knees effectively prevented pressure ulcers.
TECHNOLOGY AND HEALTH CARE
(2023)
Article
Plant Sciences
Yoon Seo Jang, Da Eun Lee, Joo-Hyun Hong, Kyung Ah Kim, Bora Kim, Yeo Rang Cho, Moon-Jin Ra, Sang-Mi Jung, Jeong-Nam Yu, Seongpil An, Ki Hyun Kim
Summary: We isolated eight marker compounds from several indigenous Korean willow species and identified dihydromyricetin as a compound that exhibits antibacterial activity against Staphylococcus aureus.
Article
Biophysics
Hyun Kyong Shon, Jin Gyeong Son, Sun Young Lee, Jeong Hee Moon, Ga Seul Lee, Kyoung-Shim Kim, Tae Geol Lee
Summary: In the study of degenerative brain diseases, changes in lipids, which are the main component of neurons, are crucial for indicating pathological changes. The researchers used ToF-SIMS with pulsed argon cluster ions to measure biomolecules, including lipids, in normal mouse brain tissue. They used OrbiSIMS, a hybrid SIMS system with an orbitrap mass analyzer, to identify the biomolecules in real tissue samples. The identification results by OrbiSIMS were confirmed by LC-MS/MS analysis of lipids extracted from mirror image tissue samples.
Article
Pediatrics
Mi Lim Chung, Heungsup Sung, Euiseok Jung, Byong Sop Lee, Ki Soo Kim, Ellen Ai-Rhan Kim
Summary: The aim of this study was to determine the rate of CMV transmission in human milk of VLBW infants, compare CMV infection rates and changes in CMV DNA viral load and nutrient profile among different milk preparation methods. The study found that the rate of CMV infection in human milk was low and had no serious impact on the clinical course of VLBW infants. However, due to potential neurodevelopmental issues in later life, further research is needed to establish guidelines for protecting VLBW infants from CMV infection transmitted through breast milk.
Article
Engineering, Environmental
Seung Jae Son, Hyeon Jin Lee, Seong Kyun Kim, Jong-Ho Lee, Hee Jung Park, Jong Hoon Joo
Summary: In this study, an oxygen-permeable membrane reactor capable of high-performance water splitting and simultaneous methane conversion was reported. The study showed that coupling water splitting and partial oxidation of methane is possible even below 800 degrees C using Ruddlesden-Popper oxide and a Ni/perovskite/fluorite composite. The optimized membrane composition ensured high ionic conductivity and stability, leading to stable hydrogen and syngas production.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Plant Sciences
Chen Huo, Sullim Lee, Min Jeong Yoo, Bum Soo Lee, Yoon Seo Jang, Ho Kyong Kim, Seulah Lee, Han Yong Bae, Ki Hyun Kim
Summary: Kaempferia parviflora, also known as Thai ginseng or black ginger, is a tropical medicinal plant traditionally used for treating various ailments. In this study, we isolated six methoxyflavones from the rhizomes of K. parviflora and found that two of them showed significant anti-melanogenic activity.
Article
Engineering, Biomedical
Joo-Eun Lee, Se Yun Jeong, Zijun Li, Hyun-Yi Kim, Hyun-Woo Kim, Min Jeong Yoo, Hee Joo Jang, Do-Kyun Kim, Namki Cho, Hee Min Yoo, Ki Hyun Kim
Summary: This study reports a screening platform to test the antiviral activity of natural products against SARS-CoV-2 and confirms their efficacy using lung organoids. Flavonoids from the natural product library showed strong antiviral activity against SARS-CoV-2 and did not affect cell viability. The screening platform provides a promising system for discovering novel drugs and potential therapeutics for COVID-19.
BIOMATERIALS RESEARCH
(2023)
Article
Chemistry, Medicinal
Da Eun Lee, Kun Hee Park, Joo-Hyun Hong, Seon Hee Kim, Ki-Moon Park, Ki Hyun Kim
Summary: The active constituent ursolic aldehyde isolated from the fruit extract of H. rhamnoides showed significant osteogenic activity and upregulated the expression of bone formation-related biomarkers. These findings suggest the potential of H. rhamnoides fruit extract as a nutraceutical for promoting bone health.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Plant Sciences
Se Yun Jeong, Akida Alishir, Shuxiang Zhang, Yinglao Zhang, Sohyeong Choi, Changhyun Pang, Han Yong Bae, Won Hee Jung, Ki Hyun Kim
Summary: Actinomycetes S. neopeptinius BYF101 was isolated from the body surface of the termite and 20 metabolites were identified, including previously unreported obscurolide-type metabolites. The study also discovered a compound with antifungal activity.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Sullim Lee, Yea Jung Choi, Chen Huo, Akida Alishir, Ki Sung Kang, Il-Ho Park, Taesu Jang, Ki Hyun Kim
Summary: Human skin is composed of the epidermis and dermis, which work together to maintain the skin's tensile strength. Skin aging, however, leads to the degradation of collagen and elastin fibers, resulting in wrinkles, pigmentation, and sagging. This study investigated natural products derived from ginkgo fruit that have protective effects against TNF-alpha-induced skin aging.
Review
Plant Sciences
Grant Koher, Ajmal Khan, Gabriel Suarez-Vega, Pornphimon Meesakul, Ann-Janin Bacani, Tomomi Kohno, Xuewei Zhu, Ki Hyun Kim, Shugeng Cao, Zhenquan Jia
Summary: The plants P. albidus, P. forbesii, P. kauaiensis, and P. ruber, collectively known as mamaki, have cultural and traditional significance in Native Hawaiian medicine. Mamaki teas, particularly bottled Shaka tea, have gained popularity in Hawaii and the United States. This review consolidates current knowledge on mamaki, highlighting its potential therapeutic properties, physical characteristics, nutritional composition, and active phytochemicals, as well as recent advances in its antibacterial, antiviral, chemopreventive, anti-inflammatory, and antioxidant activities. Future prospects in this field are also discussed.
Article
Chemistry, Analytical
Seung-Eun Lee, Se Yun Jeong, Yoon Seo Jang, Kwang-Jin Cho, Jeonghoon Lee, Yunji Lee, Ki Hyun Kim
Summary: In this study, a previously unreported bioactive compound, kirinchoside, was isolated from Sedum kamtschaticum leaves. It was found to have anti-inflammatory and blood circulation-improving effects. It also showed potential as a preventive agent against Alzheimer's disease through the inhibition of hyperphosphorylated tau accumulation.
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
