Article
Polymer Science
Jukka Niskanen, Mathieu N. Tousignant, Alexander J. Peltekoff, Benoit H. Lessard
Summary: 1,2,3-triazole based polyionic liquids have potential applications in organic electronics, with the ability to control their structure and charge to manipulate their properties. Substitution of inorganic counterions with organic counterions significantly improves the performance of metal-insulator-metal capacitors, enhancing their key performance metrics.
Article
Polymer Science
Shota Yamasaki, Yuri Kamon, Linlin Xu, Akihito Hashidzume
Summary: Through copper(I)-catalyzed and Huisgen cycloaddition reactions, 1,2,3-triazole polymers with different substituents were successfully synthesized. The crystalline properties of the polymers were influenced by the permittivity of the solvent and the type of substituents used. Additionally, the polymers exhibited fluorescence behavior in DMF, with the fluorescence peak shifting based on the excitation wavelength.
Article
Chemistry, Multidisciplinary
Suguru Yoshida, Yuki Sakata, Yoshihiro Misawa, Takamoto Morita, Tomoko Kuribara, Harumi Ito, Yuka Koike, Isao Kii, Takamitsu Hosoya
Summary: Efficient consecutive formation of 1,2,3-triazoles using multiazide platforms has been achieved in this study. A four-step synthesis of tetrakis(triazoles) was successfully performed from a tetraazide platform molecule, based on the unique clickability of the 1-adamantyl azido group. This method was applied to the convergent synthesis of tetrafunctionalized probes in a modular synthetic manner.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Applied
Gurleen Singh, Nancy George, Riddima Singh, Gurjaspreet Singh, Sushma, Gurpreet Kaur, Harminder Singh, Jandeep Singh
Summary: This review focuses on the 1,2,3-triazole-based sensor probes synthesized selectively by CuAAC, which have the ability to detect single or multiple ions under specific conditions. The review also discusses the techniques and sensing mechanisms involved in ion detection using chemosensor probes.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tamer El Malah, Hanan A. Soliman, Bahaa A. Hemdan, Randa E. Abdel Mageid, Hany F. Nour
Summary: A series of new compounds with antibacterial properties were synthesized by the research team, and their inhibitory and antibiofilm activities against methicillin-resistant Staphylococcus aureus (MRSA) were evaluated. The results showed that some compounds exhibited significant growth inhibition activity against MRSA cells, with antibiofilm effects superior to Vancomycin.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Linlin Xu, Yuri Kamon, Akihito Hashidzume
Summary: In this study, a new polyanion poly(AH) with a dense 1,2,3-triazole backbone was successfully synthesized and found to be well soluble in water under basic conditions. Poly(AH) showed weaker anionic properties compared to polyacrylic acid and exhibited a high adsorption preference for Fe3+ ions among the metal ions tested.
Article
Polymer Science
Yuri Kamon, Junji Miura, Koji Okuno, Shota Yamasaki, Masaki Nakahata, Akihito Hashidzume
Summary: Recent progress in precision polymerization techniques has allowed researchers to synthesize polymers with controlled molecular weight, tacticity, and monomer sequence. However, synthesizing uniform polymers and oligomers with specific molecular weight, tacticity, and monomer sequence remains a challenging subject.
Article
Chemistry, Physical
Tamer El Malah, Hanaa Farag, Bahaa A. Hemdan, Randa E. Abdel Mageid, Mohamad T. Abdelrahman, May A. El-Manawaty, Hany F. Nour
Summary: Antibiotic resistance poses a severe threat to humanity, prompting researchers to synthesize a series of isatin-1,2,3-triazole hybrids and evaluate their antimicrobial activity. The most active derivative displayed stronger activity against Gram-negative bacteria and showed potential for binding to specific enzymes via various interactions.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Mahdieh Mohammad Karbasi, Zohreh Mirjafary, Hamid Saeidian, Javad Mokhtari
Summary: Novel 1,2,3-triazole-dithiocarbamate hybrids were synthesized in moderate to good yields using a green solvent system, and their structures were characterized by various techniques. DFT analysis was used to study some properties of the products, with the calculated data in close agreement with experimental data.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Jigarkumar V. Mendapara, Mahesh D. Vaghasiya, Dhanji P. Rajani, Iqrar Ahmad, Harun Patel, Premlata Kumari
Summary: Cu alkyne-azide cycloaddition was used to synthesize a library of novel heterocycles containing benzimidazole and piperidine based 1,2,3-triazole(7a-7l) derivatives. The synthesized compounds were characterized by various spectroscopic techniques and evaluated for in vitro antibacterial and antifungal efficacy. Compound 7k showed potent activity against Escherichia coli and interacted with the active site of the E. coli DNA gyrase protein.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Christopher R. Butler, Justin Bendesky, Allen Milton Schoffstall
Summary: Regioselective reactions are important in synthetic organic chemistry, as seen in the reduction of 1-substituted 1,2,3-triazole 4,5-diesters where the C(5) ester groups are more reactive and the presence of a beta-hydroxyl group on the N(1)-substituent enhances the reduction rate. The regioselectivity is attributed to lower electron densities in the C(5) and C(5) ester carbonyl carbon of the 1,2,3-triazole, especially in cases involving intramolecular hydrogen bonding.
Article
Materials Science, Multidisciplinary
Jukka Niskanen, Mathieu N. Tousignant, Alexander J. Peltekoff, Benoit H. Lessard
Summary: 1,2,3-Triazolium-based polyionic liquids (PILs) with different polymer structures were synthesized through the CuAAC click reaction, and were found to exhibit prominent electrical double layer characteristics in metal-insulator-metal capacitors.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Applied
Kesavarao Sykam, Sajan Sivanandan, Pratyay Basak
Summary: The study focuses on the development of non-halogenated flame retardant and corrosion-resistant polyurethane coatings from castor oil. The experimental results demonstrate that the addition of non-halogenated flame retardant can significantly improve the flame retardancy and corrosion resistance of the coatings.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Chemistry, Physical
Przemyslaw W. Szafranski, Agata Siwek, Irena Smaga-Maslanka, Lucyna Pomierny-Chamiolo, Piotr Ilnicki, Grzegorz Zuchowski, Tapio Nevalainen, Malgorzata Filip, Pawel Zajdel, Marek T. Cegla
Summary: The copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction was used to synthesize a series of 1,4-disubstituted and 1,4,5-trisubstituted 1,2,3-triazoles. The synthesized compounds were evaluated for their affinity to the cannabinoid type 1 receptor (CB1 R). The relative configuration of a subset of 4-(3-hydroxycyclohexyl) 1,2,3-triazoles was determined using NMR and DFT-based chemical shift prediction.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Medicinal
Mathieu Michaut, Alexandre Steffen, Jean-Marie Contreras, Christophe Morice, Isabelle J. Schalk, Patrick Plesiat, Gaetan L. A. Mislin
Summary: Innovative organogold(I) antibacterial compounds were synthesized through click chemistry, exhibiting high levels of antibacterial activity against Gram-positive pathogens, with particularly low MICs against Clostridium difficile.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)