Article
Chemistry, Multidisciplinary
Kajal Rana, Trishna Pani, Somesh Kumar Jha, Devashish Mehta, Poonam Yadav, Dolly Jain, Manas Kumar Pradhan, Sarita Mishra, Raunak Kar, Betsy G. Reshma, Aasheesh Srivastava, Ujjaini Dasgupta, Veena S. Patil, Avinash Bajaj
Summary: Psoriasis is a chronic autoimmune inflammatory disease of the skin. This study presents the engineering of a betamethasone-loaded topical hydrogel that effectively treats psoriasis by reducing inflammation and improving symptoms. The hydrogel has the potential to be an alternative topical treatment for psoriasis.
Article
Microbiology
Zhehui Qu, Mingzhu Li, Ran An, Haiyue Dai, Yueyang Yu, Chenfeng Li, Chong Cao, Ye Meng, Junwei Wang, Mingchun Gao
Summary: In this study, self-assembled BPIV3 nanoparticles were prepared and found to induce BMDC maturation and enhance the immune response. HNex-RFNp showed better efficacy in preventing BPIV3 infection compared to other vaccines.
VETERINARY MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Inna S. Afonina, Elien Van Nuffel, Rudi Beyaert
Summary: Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation and aberrant differentiation of keratinocytes, leading to skin redness. The pathogenesis of psoriasis is still not completely understood, but genetic predisposition plays a significant role in its development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Wang Hee Lee, Jun Gi Rho, Yeyoung Yang, Seulbi Lee, Sohui Kweon, Hyung-Mo Kim, Juhwan Yoon, Hongseo Choi, Eunyoung Lee, Su Ha Kim, Sohee You, Yujin Song, Young Soo Oh, Hwan Kim, Hwa Seung Han, Ji Hye Han, Myeongwoo Jung, Young Hwan Park, Yang Seon Choi, Sukyoung Han, Junho Lee, Sangdun Choi, Jung-Woong Kim, Jae Hyung Park, Eun Kyung Lee, Woo Keun Song, Eunha Kim, Wook Kim
Summary: Hyaluronic acid nanoparticles (HA-NPs) have been identified as a potential topical nanomedicine for effectively and safely treating psoriasis by suppressing immune responses and restoring skin barrier function without causing overt toxicity.
Article
Nanoscience & Nanotechnology
Yong Zhou, Lei Yang, Yifu Lyu, Di Wu, Ying Zhu, Jingjing Li, Dabo Jiang, Xiaofei Xin, Lifang Yin
Summary: In this study, a ROS responsive MTX prodrug (MTX-TK-HA) was synthesized with CD44 mediated active targeting to hyperproliferative keratinocytes. MTX prodrug and PLA-mPEG were formulated by nano-precipitation method to develop the MTX-TK-HA/PLA-mPEG nanoassemblies. A dissolving microneedle was used for the transdermal delivery of these nanoassemblies. The nanoassemblies-loaded microneedle arrays effectively penetrated imiquimod-induced psoriatic skin and suppressed the proliferation of epidermal cells via NF-Kappa B pathway blockade by releasing methotrexate with ROS stimuli.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Biomedical
Yanzi Yan, Huiyi Liang, Xingliang Liu, Lixin Liu, Yongming Chen
Summary: The study reveals that poly(2-(dimethylamino)ethyl methacrylate) (PDMA) grafted hairy silica particles (cSPs) with tunable PDMA length and particle size can effectively scavenge cfDNA in the dermis, treating psoriasis. Among them, cSPs of 700 nm diameter show excellent performance with more accumulation and longer retention in psoriatic lesions, leading to better treatment results at a lower administration frequency.
Review
Immunology
Lin Shang, Jiali Cao, Siqi Zhao, Jingya Zhang, Yanling He
Summary: This article reviews the pro-inflammatory mechanisms of the JAK-STAT signaling pathway, the regulatory roles of TYK2 in the pathogenesis of psoriasis, and provides updates on ongoing and recently completed clinical trials of TYK2 inhibitors.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Spyridon Makris, Cecilia Johansson
Summary: Innate immune responses are crucial for protecting the neonatal lung, and neonatal lungs respond differently to various innate immune stimuli compared to adult lungs. Specifically, they show a weaker response to respiratory syncytial virus (RSV) but a stronger response to R848 and influenza virus, possibly due to higher levels of cAMP and enhanced responsiveness to extracellular adenosine. These findings have implications for the development of vaccine adjuvants for neonates.
MUCOSAL IMMUNOLOGY
(2021)
Article
Dermatology
Tanja Todberg, Nikolai Loft, Dina Leth Moller, Sisse Rye Ostrowski, Susanne Dam Nielsen, Lone Skov
Summary: Methotrexate has minimal effect on cytokine responses, while adalimumab affects a wide range of cytokines involved in immune defense. The cytokine levels in patients receiving long-term adalimumab treatment are almost equivalent to those receiving short-term treatment.
DERMATOLOGIC THERAPY
(2022)
Article
Mathematics, Applied
Sudhanshu Shekhar Chaurasia, Animesh Biswas, P. Parmananda, Sudeshna Sinha
Summary: This study investigates the behavior of two coupled oscillators with different timescales, finding that a large timescale mismatch leads to oscillation suppression, while phase synchronization occurs when timescales are comparable. Numerical simulations demonstrate the concept further, showing that timescale differences can be used as a tuning parameter. The findings suggest that chaos aids oscillation suppression in coupled systems, and small changes in timescales may prevent system failure and stabilize coupled systems.
Article
Chemistry, Multidisciplinary
Nan Qiao, Hairui Wang, Yanhua Xu, Yu Chang, Mingxin Xie, Shuting Bai, Chunting He, Ming Qin, Xiaofang Zhong, Min Jiang, Zhaofei Guo, Guangsheng Du, Zhirong Zhang, Yuandong Zhang, Xun Sun
Summary: Currently, widely used aluminum adjuvants have limited ability to induce effective Th1 type immune responses. However, evidence indicates that manganese could potentially serve as a metal adjuvant by activating the cGAS-STING signaling pathway to enhance humoral and cellular immune responses. In this study, researchers developed a manganese and aluminum dual-adjuvant antigen co-delivery system to improve immune responses of sub-unit vaccines. The engineered nanovaccine exhibited promising results in promoting dendritic cell maturation and inducing humoral and cellular immune responses by activating the cGAS-STING pathway.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Ana Vitoria Pupo Silvestrini, Fabiola Garcia Praca, Marcel Nani Leite, Marcia Carvalho de Abreu Fantini, Marco Andrey Cipriani Frade, Maria Vitoria Lopes Badra Bentley
Summary: Liquid crystalline nanoparticles (LCNs) have been developed as a promising topical drug delivery system for psoriasis treatment. In this study, multifunctional LCNs were designed to encapsulate triptolide (TP) and complex small interfering RNAs (siRNA) targeting TNF-alpha and IL6, demonstrating the potential for co-delivery and regulation of multiple targets. The LCNs exhibited suitable physicochemical properties, efficient encapsulation of TP, and complexation with siRNA. In vitro permeation studies showed significant enhancement of TP distribution through porcine skin after the application of LCN-TP or LCN TP in hydrogel. Cell culture experiments revealed good compatibility and rapid internalization of LCNs, with potential anti-inflammatory effects observed in LPS-stimulated macrophages. These findings suggest that the co-delivery of TP and siRNAs by LCNs could be a novel therapeutic approach for psoriasis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Ruijie Chen, Yuan-Yuan Zhai, Lining Sun, Zeqing Wang, Xing Xia, Qing Yao, Longfa Kou
Summary: Psoriasis is an immune-mediated skin disease characterized by keratinocyte hyperproliferation and aberrant differentiation. The constitutive activation of STAT3 exacerbates psoriasis by promoting cell proliferation and cytokine production. The study developed ALT-loaded nanoparticles that effectively attenuated hyperactivation of STAT3, inhibited inflammation, and restricted immune cell recruitment, showing great potential for psoriasis therapy.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Prativa Biswasroy, Deepak Pradhan, Biswakanth Kar, Goutam Ghosh, Goutam Rath
Summary: Psoriasis, an autoimmune inflammatory skin disease, is treated with drugs like MTX, CsA, acitretin, dexamethasone, and salicylic acid. However, conventional formulations have limitations, prompting the development of advanced topical nanocarriers to enhance drug delivery efficacy and address critical issues. Nanocarriers design, nano-dimensional configuration, and surface functionalization play key roles in creating effective formulations for psoriasis treatment.
Article
Dermatology
Maha A. El Gayar, Dina Atwa, Germeen Girgis, Lamees Marie
Summary: The study aimed to evaluate the efficacy and tolerability of 1% methotrexate gel and 0.005% calcipotriol cream in treating localized plaque psoriasis. The results showed that patients using methotrexate gel had a significantly higher rate of marked improvement in lesions compared to those using calcipotriol cream after 12 weeks. These findings were confirmed through dermoscopic and immunohistopathological assessments, indicating that methotrexate gel is a reliable, effective, and well-tolerated topical treatment for localized plaque psoriasis.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Allergy
Tanzeela Hanif, Lotta E. Ivaska, Freed Ahmad, Ge Tan, Emilia Mikola, Tuomo Puhakka, Oscar Palomares, Cezmi A. Akdis, Sanna Toppila-Salmi, Tuomas Jartti
Summary: This study reveals significant differences in tonsillar gene expression between atopic and non-atopic subjects, as well as between aero-allergen and food-allergen sensitization. These findings contribute to a better understanding of the immune responses and transcriptomic alterations associated with allergic sensitization.
Letter
Allergy
Miroslaw Kwasniewski, Urszula Korotko, Karolina Chwialkowska, Magdalena Niemira, Jerzy Jaroszewicz, Barbara Sobala-Szczygiel, Beata Puzanowska, Anna Moniuszko-Malinowska, Slawomir Pancewicz, Anna Parfieniuk-Kowerda, Diana Martonik, Dorota Zarebska-Michaluk, Krzysztof Simon, Monika Pazgan-Simon, Iwona Mozer-Lisewska, Maciej Bura, Agnieszka Adamek, Krzysztof Tomasiewicz, Malgorzata Pawlowska, Anna Piekarska, Aleksandra Berkan-Kawinska, Andrzej Horban, Justyna Kowalska, Regina Podlasin, Piotr Wasilewski, Arsalin Azzadin, Miroslaw Czuczwar, Michal Borys, Pawel Piwowarczyk, Slawomir Czaban, Jacek Bogocz, Magdalena Ochab, Anna Kruk, Sandra Uszok, Agnieszka Bielska, Anna Szalkowska, Justyna Raczkowska, Gabriela Sokolowska, Joanna Chorostowska-Wynimko, Aleksandra Jezela-Stanek, Adriana Rozy, Urszula Lechowicz, Urszula Polowianiuk, Agnieszka Tycinska, Kamil Grubczak, Aleksandra Starosz, Wiktoria Izdebska, Tadeusz F. Krzeminski, Jean Bousqet, Genoveffa Franchini, Jennifer Hadlock, Adam Kretowski, Mubeccel Akdis, Cezmi A. Akdis, Milena Sokolowska, Andrzej Eljaszewicz, Robert Flisiak, Marcin Moniuszko
Review
Allergy
Huan-ping Zhang, Yuan-li Sun, Yan-fen Wang, Duygu Yazici, Dilek Azkur, Ismail Ogulur, Ahmet Kursat Azkur, Zhao-wei Yang, Xiao-xue Chen, Ai-Zhi Zhang, Jia-qian Hu, Guang-Hui Liu, Mubeccel Akdis, Cezmi A. Akdis, Ya-dong Gao
Summary: There has been a significant change in the clinical characteristics and immune profile of COVID-19 patients during the pandemic, with a focus on vaccine efficacy, emergence of variants, and long-term symptoms. The association between allergic diseases and COVID-19 susceptibility and outcomes remains controversial, while preventive measures have been taken in allergic clinics. Global vaccination efforts and the appearance of reduced pathogenic variants have greatly decreased the morbidity, severity, and mortality of COVID-19, although breakthrough infections continue to be a challenge. Additionally, hypersensitivity reactions to COVID-19 vaccines are low.
Article
Allergy
Lukas E. M. Heeb, Onur Boyman
Summary: This study characterized IL-4R subunit expression in different human immune cell subsets and found that different subsets contain surface and intracellular IL-4R pools, which are differently affected by targeted biologic treatment.
Article
Immunology
Yves Zurbuchen, Jan Michler, Patrick Taeschler, Sarah Adamo, Carlo Cervia, Miro E. Raeber, Ilhan E. Acar, Jakob Nilsson, Klaus Warnatz, Michael B. Soyka, Andreas E. Moor, Onur Boyman
Summary: Boyman and colleagues conducted a study on memory B cell subsets in individuals infected with and vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They found that single memory B cell clones can adopt different trajectories. Different pathogens elicit tailored effector mechanisms and result in functionally specialized memory B cell subsets. The study showed that previously exposed individuals exhibited plasticity in SARS-CoV-2-specific memory B cell clones upon antigen rechallenge.
Article
Immunology
Kai Castrezana-Lopez, Ronja Malchow, Jakob Nilsson, Sanna M. Kokkonen, Elena Rho, Seraina von Moos, Thomas F. Mueller, Thomas Schachtner
Summary: Reducing immunosuppression in kidney transplant recipients with SARS-CoV-2 infection may increase the risk of alloantibody production, especially in patients with high PIRCHE-II scores for HLA-class II antigens.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Correction
Multidisciplinary Sciences
Urszula Radzikowska, Andrzej Eljaszewicz, Ge Tan, Nino Stocker, Anja Heider, Patrick Westermann, Silvio Steiner, Anita Dreher, Paulina Wawrzyniak, Beate Ruckert, Juan Rodriguez-Coira, Damir Zhakparov, Mengting Huang, Bogdan Jakiela, Marek Sanak, Marcin Moniuszko, Liam O'Mahony, Marek Jutel, Tatiana Kebadze, David J. Jackson, Michael R. Edwards, Volker Thiel, Sebastian L. Johnston, Cezmi A. Akdis, Milena Sokolowska
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yoshito Yamada, Tuan Thanh Nguyen, Daniela Impellizzieri, Katsutaka Mineura, Rintaro Shibuya, Alvaro Gomariz, Martina Haberecker, Jakob Nilsson, Cesar Nombela-Arrieta, Wolfgang Jungraithmayr, Onur Boyman
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Olivier de Rougemont, Yun Deng, Lukas Frischknecht, Caroline Wehmeier, Jean Villard, Sylvie Ferrari-Lacraz, Dela Golshayan, Monique Gannage, Isabelle Binet, Urs Wirthmueller, Daniel Sidler, Thomas Schachtner, Stefan Schaub, Jakob Nilsson
Summary: The type of donation may affect how susceptible a donor kidney is to injury from pre-existing alloimmunity. However, there are no large studies comparing the impact of pre-transplant donor specific antibody (DSA) stratified on donation type in a cohort with long-term follow-up. This study compared the effect of pre-transplant DSA on rejection risk, graft loss, and eGFR decline in DBD, DCD, and LD transplants.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Duygu Yazici, Eren Cagan, Ge Tan, Manru Li, Evan Do, Ozan C. Kucukkase, Abdurrahman Simsek, Muhammed Ali Kizmaz, Tugce Bozkurt, Tamer Aydin, Anja Heider, Beate Ruckert, Marie-Charlotte Bruggen, Raja Dhir, Liam O'Mahony, Mubeccel Akdis, Kari C. Nadeau, Ferah Budak, Cezmi A. Akdis, Ismail Ogulur
Summary: This study assessed the potential of biomarkers of epithelial barrier dysfunction in predicting severe COVID-19. The results showed significantly elevated levels of circulating bacterial DNA in severe COVID-19 cases, while serum bacterial DNA levels in mild cases were significantly lower than in healthy controls, suggesting tightness of the epithelial barrier as a predictor of a mild disease course. The study also identified potential early biomarkers and proteins associated with disease progression and mortality in COVID-19 patients.
Article
Allergy
Nonhlanhla Lunjani, Anoop T. Ambikan, Carol Hlela, Michael Levin, Avumile Mankahla, Jeannette I. Heldstab-Kast, Tadech Boonpiyathad, Ge Tan, Can Altunbulakli, Clive Gray, Kari C. Nadeau, Ujjwal Neogi, Cezmi A. Akdis, Liam O'Mahony
Summary: The study found that children with atopic dermatitis have a distinct gene expression pattern in their peripheral blood mononuclear cells. Early life exposures, including animals, time outdoors, and types of cooking and heating fuels, have the most significant effects on the immune cell transcriptome. Differences in gene expression patterns were also observed between rural and urban areas.
Article
Allergy
Arturo O. Rinaldi, Manru Li, Elena Barletta, Paolo D'Avino, Duygu Yazici, Yagiz Pat, Siobhan Ward, Daniel Burla, Ge Tan, Nima Askary, Rasmus Larsson, Jeremy Bost, Huseyn Babayev, Raja Dhir, Nicolas Gaudenzio, Mubeccel Akdis, Kari Nadeau, Cezmi A. Akdis, Yasutaka Mitamura
Summary: The study demonstrated that household laundry detergents and SDS impaired the epidermal barrier in both in vivo and ex vivo human skin models. Daily exposure to detergents may lead to skin barrier disruption and contribute to the development of atopic diseases. Laundry detergents caused reduced electrical impedance, disrupted major pathways involved in skin barrier integrity, and induced inflammation.
Article
Allergy
Marek Jutel, Ioana Agache, Magdalena Zemelka-Wiacek, Mubeccel Akdis, Tomas Chivato, Stefano del Giacco, Pawel Gajdanowicz, Ibon Eguiluz Gracia, Ludger Klimek, Antti Lauerma, Markus Ollert, Liam O'Mahony, Jurgen Schwarze, Mohamed H. Shamji, Isabel Skypala, Oscar Palomares, Oliver Pfaar, Maria Jose Torres, Jonathan A. Bernstein, Alvaro A. Cruz, Stephen R. Durham, Stephen J. Galli, R. Maximiliano Gomez, Emma Guttman-Yassky, Tari Haahtela, Stephen T. Holgate, Kenji Izuhara, Kenji Kabashima, Desiree E. Larenas-Linnemann, Erica von Mutius, Kari C. Nadeau, Ruby Pawankar, Tomas A. E. Platts-Mills, Scott H. Sicherer, Hae-Sim Park, Stefan Vieths, Gary Wong, Luo Zhang, M. Beatrice Bilo, Cezmi A. Akdis
Summary: The exponential growth of precision diagnostic tools has led to vast amounts of data enabling in-depth disease characterization. New disease endotypes have been identified, moving from symptom-focused descriptions to identifying biomarkers and intricate pathways. The current disease taxonomy must be revised for better categorization.
Review
Allergy
Magdalena Zemelka-Wiacek, Ioana Agache, Cezmi A. Akdis, Muebeccel Akdis, Thomas B. Casale, Stephanie Dramburg, Karina Jahnz-Rozyk, Anna Kosowska, Paolo M. Matricardi, Oliver Pfaar, Mohamed H. Shamji, Marek Jutel
Summary: The importance of allergen immunotherapy (AIT) lies in its ability to improve clinical outcomes and quality of life while reducing long-term costs. AIT induces allergen tolerance through various mechanisms, including changes in immune responses, suppression of allergen-specific IgE, and modulation of cell activation. Recent advancements in biomarkers, molecular diagnostics, and mobile health applications have the potential to enhance AIT efficacy and compliance. Additionally, artificial intelligence can aid in data interpretation and prediction of patient responses. Novel AIT preparations and advancements in clinical trial models contribute to the growth and development of AIT.
Article
Allergy
Pekka Hurme, Reetta Sahla, Beate Ruckert, Tero Vahlberg, Riitta Turunen, Tytti Vuorinen, Mubeccel Akdis, Maria Soderlund-Venermo, Cezmi Akdis, Tuomas Jartti
Summary: This study found differences in cytokine response profiles between sole RV and dual RV-HBoV1-induced first wheezing episodes. The RV-HBoV1 group showed lower expression of cytokines compared to the RV group during acute illness and convalescence. The association between hospitalization time and virus group and cytokine response suggests that certain cytokines may be related to shorter hospital stays in the RV-HBoV1 coinfection group.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)