Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 221, Issue 6, Pages 983-988Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiz514
Keywords
Atopobium vaginae; Gardnerella vaginalis; Lactobacillus crispatus; Prevotella bivia; Sneathia amnii
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Funding
- National Institutes of Health [K23HD078153-01A1, 1R15AI113457-01A1]
- Alternatives Research and Development Foundation
- Valley Research Partnership [P12]
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In recent studies, the interleukin (IL)-36 cytokines were shown to be elevated in women with non-Lactobacillus-dominated vaginal microbiomes. In this study, we evaluated IL36G expression in clinical samples from women with and without bacterial vaginosis (BV) and a human 3-dimensional cervical epithelial cell model. IL36G expression was significantly elevated in cervicovaginal epithelial cells isolated from BV-positive women and corresponded with increased neutrophil counts relative to BV-negative women. In addition, specific BV-associated bacterial species as well as a polymicrobial cocktail significantly induced IL36G expression in vitro. These findings suggest that IL-36 gamma may exhibit an important function in the host response to BV and other sexually transmitted infections.
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