Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 26, Issue 15, Pages 3395-3403Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.06.008
Keywords
Poly(ADP-ribose); Structure and properties; Biosynthesis; Cell functions; Chemical synthesis
Categories
Funding
- Academy of Sciences [Program 'Molecular and Cell Biology']
- Russian Federation President Program for young scientists [MK-8496.2016.4]
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Poly(ADP-ribose) ( PAR) is an important biopolymer, which is involved in various life processes such as DNA repair and replication, modulation of chromatin structure, transcription, cell differentiation, and in pathogenesis of various diseases such as cancer, diabetes, ischemia and inflammations. PAR is the most electronegative biopolymer and this property is essential for its binding with a wide range of proteins. Understanding of PAR functions in cell on molecular level requires chemical synthesis of regular PAR oligomers. Recently developed methodologies for chemical synthesis of PAR oligomers, will facilitate the study of various cellular processes, involving PAR. (C) 2016 Published by Elsevier Ltd.
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