C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

Role of intraganglionic transmission in the trigeminovascular pathway

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Erenumab for Preventive Treatment of Migraine: A Systematic Review and Meta-Analysis of Efficacy and Safety

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Exploration of purinergic receptors as potential anti-migraine targets using established pre-clinical migraine models

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Pathophysiological Mechanisms in Migraine and the Identification of New Therapeutic Targets

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CSD-induced arterial dilatation and plasma protein extravasation are unaffected by fremanezumab: implications for CGRP's role in migraine with aura

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Characterization of binding, functional activity and contractile responses of the selective 5‐HT 1F receptor agonist lasmiditan

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CGRP as the target of new migraine therapies — successful translation from bench to clinic

(2018) Lars Edvinsson et al.   Nature Reviews Neurology

Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

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Intact blood−brain barrier during spontaneous attacks of migraine without aura: a 3T DCE-MRI study

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The Trigeminovascular Pathway: Role of CGRP and CGRP Receptors in Migraine

(2017) Lars Edvinsson   HEADACHE

Fremanezumab - a humanized monoclonal anti-CGRP antibody — inhibits thinly myelinated (Aδ) but not unmyelinated (C) meningeal nociceptors

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The Axonal Cytoskeleton and the Assembly of Nodes of Ranvier

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Node of Ranvier length as a potential regulator of myelinated axon conduction speed

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Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies

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Localization of CGRP receptor components and receptor binding sites in rhesus monkey brainstem: A detailed study using in situ hybridization, immunofluorescence, and autoradiography

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Experimental inflammation following dural application of complete Freund’s adjuvant or inflammatory soup does not alter brain and trigeminal microvascular passage

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The node of Ranvier in CNS pathology

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A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief

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Calcitonin Gene-Related Peptide: Physiology and Pathophysiology

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Altered PKA modulation in the Nav1.1 epilepsy variant I1656M

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Differentiation of Nerve Fibers Storing CGRP and CGRP Receptors in the Peripheral Trigeminovascular System

(2013) Sajedeh Eftekhari et al.   JOURNAL OF PAIN

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models

(2013) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level

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NXN-188, a selective nNOS inhibitor and a 5-HT1B/1D receptor agonist, inhibits CGRP release in preclinical migraine models

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Direct Interactions between Calcitonin-Like Receptor (CLR) and CGRP-Receptor Component Protein (RCP) Regulate CGRP Receptor Signaling

(2012) Sophie C. Egea et al.   ENDOCRINOLOGY

Expression of Nav1.7 in DRG Neurons Extends from Peripheral Terminals in the Skin to Central Preterminal Branches and Terminals in the Dorsal Horn

(2012) Joel A Black et al.   Molecular Pain

mRNA expression of 5-hydroxytryptamine 1B, 1D, and 1F receptors and their role in controlling the release of calcitonin gene–related peptide in the rat trigeminovascular system

(2012) Dipak V. Amrutkar et al.   PAIN

The Cyclic AMP Pathway

(2012) P. Sassone-Corsi   Cold Spring Harbor Perspectives in Biology

Permeability of the Paranodal Junction of Myelinated Nerve Fibers

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Regulation of sodium channel activity by phosphorylation

(2010) Todd Scheuer   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pharmacokinetics and Brain Uptake of a Genetically Engineered Bifunctional Fusion Antibody Targeting the Mouse Transferrin Receptor

(2009) Ruben J. Boado et al.   MOLECULAR PHARMACEUTICS

The Blood-Brain Barrier in Migraine Treatment

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Biophysical Properties of Human Nav1.7 Splice Variants and Their Regulation by Protein Kinase A

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