Review
Oncology
Jie Sun, Jieting Jiang, Yiyan Wang, Mingyue Zhang, Lu Dong, Kunpeng Li, Caiqin Wu
Summary: Reminiscence therapy (RT) has significant efficacy in relieving cancer-related symptoms such as anxiety and depression in cancer survivors. It can effectively improve the quality of life, self-hope, and self-esteem of patients. The findings of this meta-analysis provide direction for future symptom management research.
INTEGRATIVE CANCER THERAPIES
(2023)
Article
Psychology, Multidisciplinary
Herve Platel, Marie-Loup Eustache, Renaud Coppalle, Armelle Viard, Francis Eustache, Mathilde Groussard, Beatrice Desgranges
Summary: Studies have shown that Alzheimer's Disease patients with severe dementia can maintain consistent, albeit impoverished, representations of themselves and a preserved sense of identity even at advanced stages of the illness. Participation in reminiscence workshops with familiar songs as prompts can enrich autobiographical memories and support self-representation for these patients. However, while autobiographical memories of AD patients can reach levels comparable to matched controls with repeated participation, this increase in memories does not necessarily lead to enriched sense of identity.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Geriatrics & Gerontology
Lin Tz-Han, Wu Wan-Ru, Chen I-Hui, Huang Hui-Chuan
Summary: This study explored the effectiveness and feasibility of a reminiscence music therapy program for older adults with dementia, aiming to improve cognition while reducing depressive and behavioral symptoms. Participants in the intervention group received 60-minute sessions of reminiscence music therapy twice a week for 4 weeks, while the control group received usual care. The results showed a significant reduction in depressive symptoms for the intervention group, but no significant effects on cognition and behavioral symptoms were observed. The high adherence and positive participation data suggested that this reminiscence music program is feasible for individuals with dementia. Healthcare professionals can consider incorporating supportive environments and regular reminiscence music activities, specifically related to festivals and memorable music, to decrease depressive symptoms in older adults with dementia.
Article
Clinical Neurology
Johannes Levin, Jonathan Voglein, Yakeel T. Quiroz, Randall J. Bateman, Valentina Ghisays, Francisco Lopera, Eric McDade, Eric Reiman, Pierre N. Tariot, John C. Morris
Summary: The amyloid cascade hypothesis for Alzheimer's disease has faced challenges due to inconsistent clinical benefits of drugs targeting amyloid beta peptide. It is important to conduct intervention studies in cognitively unimpaired individuals at risk for dementia to further evaluate the hypothesis.
ALZHEIMERS & DEMENTIA
(2022)
Article
Nanoscience & Nanotechnology
Yanan Liu, Yutong Chen, Youcong Gong, Huawen Yang, Jie Liu
Summary: The important causes of microglial dysfunction in Alzheimer's disease (AD) include accumulation of amyloid beta (Aβ) fibrils, elevated reactive oxygen species (ROS), and hypoxia. Photothermal therapy (PTT) using a polydopamine-ruthenium nanosystem (PDA-Ru) is shown to effectively decrease Aβ deposition and restore the neuroregulatory function of microglia in AD mice. This versatile nanomaterial could serve as a potential strategy for the treatment of AD and other neurodegenerative diseases.
ACS APPLIED NANO MATERIALS
(2023)
Article
Health Care Sciences & Services
Victor Morales-de-Jesus, Helena Gomez-Adorno, Maria Somodevilla-Garcia, Darnes Vilarino
Summary: Reminiscence therapy is a non-pharmacological intervention that helps alleviate unstable psychological and emotional states in patients with Alzheimer's disease by evoking past memories through conversations. A conversational system has been developed to provide personalized reminiscence therapy for patients with Alzheimer's, and evaluation shows successful implementation of the therapy.
Article
Clinical Neurology
Prashanthi Vemuri, Charles Decarli, Marco Duering
Summary: This focused review provides an update on current magnetic resonance imaging methods for measuring cerebrovascular disease lesions and early cerebrovascular disease-related brain injury. It discusses the clinical implications and relevance of these imaging markers for cognitive decline, incident dementia, and disease progression in Alzheimer's disease and related dementias. The review also presents the outlook and challenges in the field.
Article
Chemistry, Multidisciplinary
Qianhua Feng, Ning Wang, Xueli Zhang, Yuying Mei, Rongkun Fu, Jing Chen, Xiaomin Yuan, Shuaiqi Yang, Zhenzhong Zhang, Hongjuan Zhao, Lei Wang
Summary: A nanoparticle cluster is designed to prevent amyloid fibrillation by binding to amyloid-beta through a multivalent binding strategy. The cluster decomposes into smaller nanoparticles upon reaching the Alzheimer's disease nidus, which bind strongly to amyloid-beta and disrupt amyloid interactions. The resulting nanoparticle-amyloid composite delivers rapamycin to microglia, improving the immune dysfunction and removing amyloid-beta, ultimately rescuing memory deficits in Alzheimer's disease.
Review
Biotechnology & Applied Microbiology
Yanyan Cao, Run Zhang
Summary: This review outlines the developments and benefits of nanomedicines in treating Alzheimer's disease (AD), highlighting the potential of nanotechnology in diagnosing and providing alternative treatments for this neurodegenerative condition. Prospective nanomedicines for diagnosing and surveillance therapeutic interventions for AD and other diseases of the central nervous system (CNS) may be clinically accessible, driving further research in this field.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
John P. Seibyl
Summary: Diseases of the central nervous system, such as Alzheimer's and Parkinson's, are common and chronic conditions with significant morbidity. Abnormal protein accumulation and spread in the brain are found to be the primary factors in neurotoxicity and disruption of functional networks. Clinical trials are currently investigating various therapies to target these proteinopathies, although they face challenges in accurate diagnosis, variable rates of progression, and efficacy measures.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Editorial Material
Cell Biology
Julian M. Carosi, Timothy J. Sargeant
Summary: The potential use of rapamycin for treating Alzheimer's disease has been studied, suggesting promise for early prevention but limited effectiveness in resolving existing pathology. The impact of lysosomal degradative capacity on rapamycin's effectiveness in Alzheimer's treatment needs further investigation.
Article
Medicine, General & Internal
Kangmei Zhou, Jierong He, Lin Quan, Rong Guo
Summary: This study aims to evaluate the efficacy of acupuncture combined with Western medicine in improving cognitive function and activities of daily living in patients with Alzheimer's disease (AD). Using a randomized, single-blind, sham-acupuncture controlled trial, participants will be divided into treatment and control groups. After 24 weeks of continuous treatment, they will be followed up for another 24 weeks. Outcome measures include various assessments and blood tests. The results of this study will help determine whether the efficacy of acupuncture in the treatment of AD is due to the placebo effect.
Article
Clinical Neurology
J. Delrieu, R. J. Bateman, J. Touchon, M. Sabbagh, J. Cummings
Summary: The approval of Aducanumab and other anti-amyloid antibodies will change the design of future clinical trials, promoting the selection of patients with appropriate biology through amyloid and tau biomarkers. These agents also provide the opportunity to test combined drug therapies and conduct comparative assessments with innovative therapies.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Yefei Jiang, Zhiyong Zeng, Jianhua Yao, Ying Guan, Peipei Jia, Xiaoli Zhao, Lin Xu
Summary: Alzheimer's disease is a neurodegenerative disease characterized by the aggregation of β-amyloid (A,B). Although efforts have been made to control A,B aggregation, no effective medications have been developed. Photodynamic treatment, due to its excellent temporal and spatial selectivity, has been employed to intervene in the aggregation process with some success. This paper reviews the progress of small-molecule photosensitizers in recent years and outlines existing strategies and potential obstacles for enhancing the research and application of photodynamic therapy in Alzheimer's disease.
CHINESE CHEMICAL LETTERS
(2023)
Article
Clinical Neurology
Virginia D. Buckles, Chengjie Xiong, Randall J. Bateman, Jason Hassenstab, Ricardo Allegri, Sarah B. Berman, Jasmeer P. Chhatwal, Adrian Danek, Anne M. Fagan, Bernardino Ghetti, Alison Goate, Neill Graff-Radford, Mathias Jucker, Johannes Levin, Daniel S. Marcus, Colin L. Masters, Lena McCue, Eric McDade, Hiroshi Mori, Krista L. Moulder, James M. Noble, Katrina Paumier, Oliver Preische, John M. Ringman, Nick C. Fox, Stephen Salloway, Peter R. Schofield, Ralph Martins, Jonathan Voglein, John C. Morris
Summary: As prevention trials progress with ADAD participants, it is important to understand similarities and differences with sporadic LOAD to ensure generalizability of findings. Cognitive trajectories of ADAD MCs were compared to autopsy-confirmed LOAD individuals, showing differences in rates of decline between the two groups. While both groups showed declining cognitive performance, ADAD MCs declined more rapidly post-symptom onset, indicating common AD pathologies but with some distinct differences.
ALZHEIMERS & DEMENTIA
(2022)