Synthesis, structures and urease inhibitory activity of cobalt(III) complexes with Schiff bases

A series of new cobalt(III) complexes were prepared. They are [CoL1(py)(3)]center dot NO3 (1), [CoL2(bipy)(N-3)]center dot CH3OH (2), [CoL3(HL3)(N-3)]center dot NO3 (3), and [CoL4(MeOH)(N-3)] (4), where L-1, L-2, L-3 and L-4 are the deprotonated form of N'-(2- hydroxy-5-methoxybenzylidene)-3-methylbenzohydrazide, N'-(2-hydroxybenzylidene)-3-hydroxylbenzohydrazide, 2-[(2-dimethylaminoethylimino) methyl]-4-methylphenol, and N, N'-bis(5-methylsalicylidene)-o-phenylenediamine, respectively, py is pyridine, and bipy is 2,2'-bipyridine. The complexes were characterized by infrared and UV-Vis spectra, and single crystal X-ray diffraction. The Co atoms in the complexes are in octahedral coordination. Complexes 1 and 4 show effective urease inhibitory activities, with IC50 values of 4.27 and 0.35 mu mol L-1, respectively. Complex 2 has medium activity against urease, with IC50 value of 68.7 mu mol L-1. While complex 3 has no activity against urease. Molecular docking study of the complexes with Helicobacter pylori urease was performed. (C) 2015 Elsevier Ltd. All rights reserved.