Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4-arylamino-6-ureido and thioureido-quinazoline derivatives

Title
Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4-arylamino-6-ureido and thioureido-quinazoline derivatives
Authors
Keywords
EGFR inhibitors, Quinazolines, Urea derivatives, Synthesis, EGFR-Her2 dual inhibitors, EGFR L858R/T790 mutant, EGFR Del19/T790M mutant
Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 24, Issue 16, Pages 3501-3512
Publisher
Elsevier BV
Online
2016-05-31
DOI
10.1016/j.bmc.2016.05.063

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